Hepatoprotective Effect of Quercetin Pretreatment Against Paracetamol-Induced Liver Damage and Partial Hepatectomy in Rats

Barros, Pedro Paulo; Silva, Gustavo Henrique da; Gonçalves, Gisele Mara Silva; Oliveira, Jessica Cristiane; Pagnan, Livia Gonçalves; Arco-e-Flexa, Luiza

doi:10.1590/1678-4324-2016160138

Cited by 19 publications

(25 citation statements)

References 38 publications

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“…Three animals remained in each box with free access to tap water. All animals were allowed to acclimatize for a week, followed by randomization and allocation (8)(9)(10)(11)(12) . There were two groups (n=12): rutin group (G1) received suspension 40 mg rutin /kg/day for 10 days, prior to the performance of partial hepatectomy, administered orally (gastric gavage).…”

Section: Methodsmentioning

confidence: 99%

“…The removal of almost 70% of the liver tissue was performed after a 12-hour fast and administering anesthesia with high dose of xylazine and ketamine solution via intraperitoneal (8)(9)(10)(11)(12) . A sensitivity test was performed on the lower and upper limbs before the start of the surgical procedure.…”

Section: Partial Hepatectomy Sample Collection Euthanasia and Histomentioning

confidence: 99%

“…Euthanasia was performed by deepening anesthesia. All the histological analyses were performed in an optic microscope by counting the number of mitoses and apoptosis and observing the general appearance of the liver tissue (8)(9)(10)(11) .…”

Section: Partial Hepatectomy Sample Collection Euthanasia and Histomentioning

confidence: 99%

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Oral Rutin Suspension Intervene in Hepatic Hyperplasia in Rats

Barros

Eisinger

Gonçalves

et al. 2020

Arq. Gastroenterol.

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BACKGROUND: Rutin is a flavonol glycoside that can be found in a wide variety of vegetables and has activity, anti-cancer, anti-inflammatory and anti-diabetic properties. OBJECTIVE: This study investigated the effect of rutin oral administration on Wistar rats submitted to hepatic hyperplasia after partial hepatectomy (PH). METHODS: To achieve this, we considered the analysis of hepatic hyperplastic and plasma biochemical activity of Wistar rats, subjected to treatment with rutin 40 mg/kg/day for 10 days in group 1 (G1) or saline in group 2 (G2), followed by partial hepatectomy. RESULTS: The results indicated an increase in the number of mitoses after 24 hours and 48 hours (P=0.0022 and P=0.0152, respectively) of PH in the group that received rutin, as well as an increase in AST serum levels after 24 hours (P=0.0159) and 48 hours (P=0.0158) and alkaline phosphatase after 24 hours (P=0.015) in the same group, in relation to the respective controls. The group that received rutin showed a more evident variation than the control group when comparing the 24 hour and 48 hour results regarding AST, number of mitoses and number of apoptosis (P<0.005). CONCLUSION: It was concluded that rutin intervened in hepatic hyperplasia after 24 hours and 48 hours of PH, favoring hepatic hyperplasia.

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Section: Methodsmentioning

confidence: 99%

Section: Partial Hepatectomy Sample Collection Euthanasia and Histomentioning

confidence: 99%

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Oral Rutin Suspension Intervene in Hepatic Hyperplasia in Rats

Barros

Eisinger

Gonçalves

et al. 2020

Arq. Gastroenterol.

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“…In view of the antioxidant and antiinflammatory properties attributed to capsiate, we hypothesize that this substance may have a hepatoprotective action like other substances with the same properties such as quercetin 14 .…”

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confidence: 99%

Capsiate treatment in liver surgeries may compromise its recovery

et al. 2018

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“…Explanations include the increase number of invasive procedures performed, and the use of immunosuppressants and aggressive surgeries in this population 8 . Although the focus of much research, little has changed in the management of patients with sepsis over recent decades, the information acquired from basic research has resulted in interventions that are of little or no effect at all in humans, and this may be a consequence of dissociation between the real world, in which more than 60% of the cases of sepsis occur in individuals over 60 years of age, and experimental research, where the majority of the animals studied are young 7,[14][15][16][17][18][19] . with their respective solution at a dose of 4 ml/ kg of weight, a dose that had been confirmed as sub-lethal for that age in a previous study 24 .…”

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confidence: 99%

Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies

Mascena

Filho²,

Júnior

et al. 2018

Acta Cir. Bras.

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Purpose: To evaluate the response of aging rats with sepsis to two different antibiotic regimens. Methods: The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups: Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups. Results: At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967). Conclusion: Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis.

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Hepatoprotective Effect of Quercetin Pretreatment Against Paracetamol-Induced Liver Damage and Partial Hepatectomy in Rats

Abstract: Quercetin has potent antioxidant action and a hepatoprotective role. The aim of this study was to evaluate the hepatoprotective action of quercetin pretreatment in paracetamol-induced liver damage (PILD) and structural injury resulting from partial hepatectomy (PH

Cited by 19 publications

References 38 publications

Oral Rutin Suspension Intervene in Hepatic Hyperplasia in Rats

Oral Rutin Suspension Intervene in Hepatic Hyperplasia in Rats

Capsiate treatment in liver surgeries may compromise its recovery

Fecal peritonitis in aging rat model. Therapeutic response to different antibiotic strategies

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