Purpose: To evaluate the response of aging rats with sepsis to two different antibiotic regimens. Methods: The study was conducted with 30 aging rats (18 month-old) with autologous feces peritonitis. The animals were divided into three groups: Group 0 received no therapeutic intervention (control), while Group 1 received a single dose of 40 mg/kg meropenem and Group 2 received a single dose of 20 mg/kg moxifloxacin. The intervention in both Groups was made 6 hours after induction of peritonitis. The animals were followed up to 15 days for evaluating morbidity and mortality. The weights at baseline were similar in all groups. Results: At the end of follow-up, weight loss was significantly greater (p=0.0045) in Group 0 (non-intervention controls). Culture from a blood sample at the end of follow-up was positive in all the animals in Group 0, in two animals in Group 1 and in four animals in Group 2. Morbidity/mortality was significantly higher in Group 0 compared to both Groups 1 and 2 (p=0.003) but the scores were not significantly different between Groups 1 and 2 (p=0.6967). Conclusion: Both antibiotic regimens rendered promising results for the treatment of fecal peritonitis.
Objetivo: Analisar o desfecho materno-fetal do uso do Lítio durante a gravidez. Métodos: A pesquisa de revisão integrativa seguiu etapas, no qual realizou-se uma busca em bases de dados e bibliotecas virtuais: U.S National Library of Medicine (PubMed), Biblioteca Virtual de Saúde (BVS) Scientific Eletronic Library Online (SciELO) e Literatura Latino-Americana e do Caribe em ciências da Saúde (LILACS), com o cruzamento dos descritores “Gravidez” & “Lítio”. Sete artigos foram selecionados para a pesquisa, e todos se encontravam em língua inglesa e na base de dados BVS. Resultados: Todos os autores utilizaram o público gestante e/ou seus filhos com a intervenção do lítio. Observou-se que apenas 28,57% (n=2) associaram o uso do medicamento com desfechos negativos para a população materno-fetal, e um deles associa ao transtorno bipolar, independente do uso da medicação. Já 71,42% (n=5) dos estudos validaram os seus efeitos proveitosos quando relacionado ao risco-benefício do uso do lítio. Considerações finais: Apesar dos dados apresentarem divergências, a maioria relata que a escolha para a terapêutica deve ser direcionada, dando importância a individualização do caso e mostrando segurança na terapêutica com o lítio. Além disso, confirma-se a escassez de estudos claros sobre o tratamento, necessitando de pesquisas mais aprofundadas.
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