Histopathological hoof laminar changes in horses with Pituitary Pars Intermedia Adenoma: cases report

Abstract

Laminitis in horses is often associated with endocrine disorders, especially the pituitary pars intermedia dysfunction (PPID) in older animals. Morphologic exams of the laminar tissue of the hoof were performed in two horses with suspected PPID, with no clinical signs of laminitis. Changes compatible with laminitis of endocrine origin were observed, such as rounding of the nuclei of the basal cells, thinning and stretching of the secondary epidermal laminae and tissue proliferation. PPID horses with no clinical signs of laminitis may be affected by lesions of the laminar tissue of the hoof that compromise the integrity of the dermal-epidermal junction and may develop clinical symptoms of the disease. It has been suggested that the development stage of endocrine laminitis is longer, but further studies should be conducted to confirm it.Keywords: laminitis, metabolic syndrome, Cushing's syndrome, endocrine disorders, pituitary adenoma RESUMO A laminite em cavalos está frequentemente associada a distúrbios endócrinos, como a disfunção da pars intermedia da pituitária (PPID) em animais mais velhos. Exames morfológicos do tecido laminar do

Clinical and Diagnostic Studies of Acute Laminitis in Foals

“…Moreover, others, de Laat et al [33], indicated that the important potential relevance concerning acute laminitis is, the construction and ultimate strength of the resultant lamellar interface could be highly improved by strategically minimizing the mechanical displacement within the acute phase of laminitis. On the other hand, Laskoski et al [34], concluded that the lamellar tissue was able to re-arrange quickly after an episode of acute laminitis. Despite the absence of histopathological indications of existing acute laminitis for several days, there was a noticeable disturbance of the lamellar architecture.…”