Occurrence of gastric ulcers and serum gastrin levels in jumping horses

Abstract

The aim of this study was to determine the occurrence of EGUS and to quantify serum gastrin levels in jumping horses during competition season and interseason period. Forty jumping horses, competing at high level were randomly allocated into two groups, the Training Group: twenty jumping horses undergoing intense training and participating in competitions, and the Rest Group: twenty jumping horses in the interseason (resting period). The gastroscopic examinations and blood samples of the horses in the training group were performed 1-2 days following the competition while in the horses of the rest group, following 4 weeks of rest. The serum gastrin levels were measured at two different times: pre-feeding and two hours after feeding the horses (postprandial) by ELISA kit. Gastric lesion score data were compared by the Mann-Whitney U test (α= 0.05) and the mean gastrin values were compared between the groups and between the two moments by the paired tet tests, respectively (α= 0, 05). Squamous gastric ulcers were detected in 42.5% of all jumping horses examined independent of the period, competition season or interseason. Serum gastrin levels were significantly higher in the Training Group with no difference between pre-feeding and postprandial values.

Evaluation of the effects of medium‐term (57‐day) omeprazole administration and of omeprazole discontinuation on serum gastrin and serum chromogranin A concentrations in the horse

“…Although baseline serum measurements were taken for each horse, having control horses that were not treated with omeprazole within the same training environment might have been advantageous. Furthermore, serum gastrin concentrations are higher in horses in training than in those at rest and higher post‐feeding in horses in training, suggesting exercise and feeding to be factors affecting serum gastrin concentrations in addition to the influence of omeprazole treatment 25,26 . Our study design controlled for exercise, feeding and timing of sample collection, while determining that serum gastrin concentrations increased with omeprazole treatment and returned to baseline after omeprazole discontinuation.…”

“…Furthermore, serum gastrin concentrations are higher in horses in training than in those at rest and higher post‐feeding in horses in training, suggesting exercise and feeding to be factors affecting serum gastrin concentrations in addition to the influence of omeprazole treatment. 25 , 26 Our study design controlled for exercise, feeding and timing of sample collection, while determining that serum gastrin concentrations increased with omeprazole treatment and returned to baseline after omeprazole discontinuation. Gastroscopy was performed in each horse, but these findings were reported in another study.…”

Cólica Em Equinos

“…O intestino delgado dos equinos possui comprimento médio de 20 metros, sendo dividido em: duodeno, jejuno e íleo (DANIELS et al, 2019). A mucosa possui vilosidades de 0,5 a 1 mm, revestidas por células epiteliais com microvilosidades destinadas a aumentar a superfície absortiva, células caliciformes secretoras de muco e glândulas secretoras de suco entérico (RIBEIRO et al, 2019).…”

“…A camada muscular lisa dos intestinos é localizada abaixo da mucosa, sendo responsável por peristaltismo, o qual mistura o conteúdo e o propulsiona em sentido crânio caudal por meio de contrações rítmicas (FIELDING, 2018). O pâncreas produz secreção de forma contínua com baixa concentração de enzimas equivalente de 5 a 10% do peso corporal do animal (RIBEIRO et al, 2019).…”

“…O intestino grosso do equino possui aproximadamente sete metros de comprimento, sendo dividido em ceco, cólon e reto. Estas são estruturas essenciais do trato digestivo do equino, por conter micro-organismos capazes de fermentar as bras e os nutrientes não absorvidos no intestino delgado (RIBEIRO et al, 2019). O bolo alimentar passa ao ceco pela junção ileocecal.…”