Phytochemical analysis and biological activities of ethanolic extract of Curcuma longa rhizome

Abstract

Curcuma longa is an important dietary plant which possess several pharmacological activities, including antioxidant, antimicrobial, anti-inflamatory, anticancer and anti clotting etc. The aim of the present study was to determine the phenolic profile of Curcuma longa and in vitro antioxidant and antidiabetic activities. In HPLC chromatogram of Curcuma longa rhizome extract 15 phenolic compounds were identified namely Digalloyl-hexoside, Caffeic acid hexoside, Curdione, Coumaric, Caffeic acid, Sinapic acid, Qurecetin-3-D-galactoside, Casuarinin, Bisdemethoxycurcumin, Curcuminol, Demethoxycurcumin, and Isorhamnetin, Valoneic acid bilactone, Curcumin, Curcumin-O-glucuronide respectively. The ethanolic extract displayed an IC50 value of 37.1±0.3 µg/ml against alpha glucosidase. The IC50 value of DPPH radical scavenging activity was 27.2 ± 1.1 μg/mL. It is concluded that ethanolic extract of Curcuma long is rich source of curcumin and contain several important phenolics. The in vitro antioxidant and alpha glucosidase inhibitory effect of the plant justifies its popular use in traditional medicine.

The Biological Effects of Novel Nutraceuticals with Curcuminoids and Other Plant-Derived Immunomodulators and Pre-Probiotics

“…The flavonoid content represents approximately 14.21% of the total polyphenols for the immunomodulatory product and 2.85% for the pre- and probiotic product ( Table 1 ). In fact, the polyphenol content determined by the Folin Ciocalteu method probably comes from the following ingredients: Chelidonium majus (rich in quercetin, caffeic acid and neochlorogenic acid) [ 48 ], Trigonella foenum-graecum (apigenin, luteolin and kaempferol as aglycones and hydroxycinnamic acids mostly dominated by caffeic acid derivatives) [ 49 ], Curcuma longa (chlorogenic acid, curcuminoids, isorhamnetin, digalloyl-hexoside) [ 50 ] extract and vitamin C for the first product while for the second product the continuum of polyphenols and flavonoids, respectively, is given by Helianthus tuberosus (chlorogenic and dicaffeoylquinic acids) [ 51 ] and Plantago ovata (gallic acid and rutin) [ 52 ].…”

Potencial antimicrobiano das nanopartículas de prata estabilizadas em curcumina e extrato de folhas de cajueiro (Anacardium occidentale L.)

“…A curcumina é um composto ou um ingrediente presente no rizoma da planta (Curcuma longa) é um polifenol amplamente usado como corante natural tem ação antioxidante, antimicrobiana, anticoagulante e anticâncer (Carneiro JA;Macedo, 2020). Devido estas ações é muito usada em diversas atividades farmacológicas (Sabir et al, 2021). Os grupos fenólicos, β-dicetana e metila presentes na curcumina, além de ter um efeito autorregulador (Judaki et al, 2017) podem tem a capacidade de reduzir e estabilizar nanopartículas da prata a partir do nitrato de prata.…”

“…Diante do potencial antimicrobiano da curcumina (Sabir et al, 2021), do extrato de cajueiro (Silva et al, 2021) e das nanopartículas de prata (Orellano P, et al, 2021) já descrito na literatura a pesquisa tem como objetivo analisar o potencial antimicrobiano das nanopartículas de prata estabilizadas em curcumina e extrato de folhas de cajueiro (Anacardium occidentale L).…”

A comparative study to evaluate the effects of antibiotics, plant extracts and fluoride-based toothpaste on the oral pathogens isolated from patients with gum diseases in Pakistan

“…Brazilian Journal of Biology, 2023, vol. 83, e242703 3/11 Evaluation of antibiotics, plant extract and toothpaste in oral pathogens several clinical tests (Sabir et al, 2021). Curcumin or curcuminoids are the most studied constituent of turmeric.…”