Efficacy of application of Equisetum pyramidale Goldm. hydrogel for tissue restoration of induced skin lesions in Wistar rats

Abstract

<jats:p>Abstract Medicinal plants, such as E. pyramidale, are alternatives against infections and assist in the healing process of wounds. We evaluated the effects of Hydrogel of E. pyramidale on the healing of cutaneous wounds in animal models by morphological, morphometric and histological analyses, and elucidated major components. The ethanolic extract of E. pyramidale shoots was submitted to phytochemical analysis. For cicatrizing activity assay, Wistar rats were used, and the groups evaluated were hydrogel containing ethanolic extract of E. pyramidale at 2% compared to control groups. The treatment periods were 3, 7 and 21 days, and macroscopic and microscopic analyses were performed. Data were submitted to Analysis of Variance (p &lt;0.05). Phytochemistry and quantification evidenced that flavonoids are main constituents and that they were evidenced by thin layer chromatography (TLC), high efficiency (HPLC) and infrared (IR) methods. In TLC, using flavonoid patterns, we observed pinocembrin. The hydrogel containing ethanolic extract of E. pyramidale at 2% was effective in wound regression. E. pyramidale can be used for the treatment of second intention wounds, and the effective healing may be due to a high flavonoid content.</jats:p>

Hydrogels for the Delivery of Plant-Derived (Poly)Phenols

“…HGs to vehicle RU [ 24 , 25 ], CGA [ 26 ], Q [ 27 ], FA [ 28 ], and oligomeric proanthocyanidins (OPC) [ 29 ], as well as polyphenol-rich plant extracts [ 30 , 31 ], appeared effective in ameliorating wound healing in in vivo rat and mouse models, and also in animals with diabetes mellitus experimentally induced by streptozotocin or alloxan ( Table 1 ) [ 28 , 29 , 30 , 31 ]. An innovative RU-conjugated CS-HG was projected by Tran N.Q.…”

“…Another plant extract-containing HG with potential applicability for tissue restoration of skin wounds has been developed by Carmignan F. et al [ 30 ]. The composition of the HG is simply made by Carbopol (1%), methylparaben (0.1%; preservative) and water as a vehicle, to which was added the ethanolic extract (2%) of Equisetum pyramidale shoots.…”

“…The in vitro studies confirmed the antioxidant activity of this formulation, which is also safe on fibroblasts and able to stimulate the antioxidant defense system in the initial phase of the healing process. Another plant extract-containing HG with potential applicability for tissue restoration of skin wounds has been developed by Carmignan F. et al [30]. The composition of the HG is simply made by Carbopol (1%), methylparaben (0.1%; preservative) and water as a vehicle, to which was added the ethanolic extract (2%) of Equisetum pyramidale shoots.…”

“…The composition of the HG is simply made by Carbopol (1%), methylparaben (0.1%; preservative) and water as a vehicle, to which was added the ethanolic extract (2%) of Equisetum pyramidale shoots. This medicinal plant (also known as "cavalinha" or "horsetail") is included in the Brazilian health care system as a valid and low-cost Another plant extract-containing HG with potential applicability for tissue restoration of skin wounds has been developed by Carmignan F. et al [30]. The composition of the HG is simply made by Carbopol (1%), methylparaben (0.1%; preservative) and water as a vehicle, to which was added the ethanolic extract (2%) of Equisetum pyramidale shoots.…”

Cirurgias De Câncer Colorretais E Síndrome Da Ressecção Retal Anterior: Complicações E Impactos Na Qualidade De Vida

“…Dessa forma, o tempo de reparo tecidual diminui à medida em que há a manifestações no processo cicatrizante com os processos ativados mediados por citocinas, fatores de crescimento e atividade enzimática (LIMA et al, 2009). Nessa perspectiva, os avanços desse processo tanto a compreensão quanto o desenvolvimento de tecnologias mais novas tem ganhado força e estão em andamento (CARMIGNAN. et al, 2019).…”