Quercetin and rutin as potential agents antifungal against Cryptococcus spp

Oliveira, Vanessa; Carraro, Emerson; Auler, Marcos Ereno; Khalil, Najeh Maissar

doi:10.1590/1519-6984.07415

Cited by 72 publications

(33 citation statements)

References 29 publications

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“…Also, Qu et al [84] revealed the synergetic effect of quercetin-tetracycline combination treatment against multi-drug resistant (MDR) E. coli by disrupting the bacterial cell envelope, thus improving its permeability and cell lysis. Quercetin has been documented to improve the antifungal efficacy of amphotericin B against Candida sp and Cryptococcus neoformans strains by reducing its toxic effect [85]. Another study demonstrated the potent synergistic efficacy of quercetin against fluconazole-resistant strains of Candida tropicalis by enhancing mitochondrial membrane alterations that affect the mitochondrial respiratory function and inhibiting rhodamine-123 accumulation in the mitochondria [86].…”

Section: Combination Therapy Of Quercetin With Other Drugsmentioning

confidence: 99%

The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin

Batiha

Beshbishy

Ikram

et al. 2020

Foods

384

178

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Flavonoids are a class of natural substances present in plants, fruits, vegetables, wine, bulbs, bark, stems, roots, and tea. Several attempts are being made to isolate such natural products, which are popular for their health benefits. Flavonoids are now seen as an essential component in a number of cosmetic, pharmaceutical, and medicinal formulations. Quercetin is the major polyphenolic flavonoid found in food products, including berries, apples, cauliflower, tea, cabbage, nuts, and onions that have traditionally been treated as anticancer and antiviral, and used for the treatment of allergic, metabolic, and inflammatory disorders, eye and cardiovascular diseases, and arthritis. Pharmacologically, quercetin has been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia, and Theileria parasites. Additionally, it has shown beneficial effects against Alzheimer’s disease (AD), and this activity is due to its inhibitory effect against acetylcholinesterase. It has also been documented to possess antioxidant, antifungal, anti-carcinogenic, hepatoprotective, and cytotoxic activity. Quercetin has been documented to accumulate in the lungs, liver, kidneys, and small intestines, with lower levels seen in the brain, heart, and spleen, and it is extracted through the renal, fecal, and respiratory systems. The current review examines the pharmacokinetics, as well as the toxic and biological activities of quercetin.

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Section: Combination Therapy Of Quercetin With Other Drugsmentioning

confidence: 99%

The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin

Batiha

Beshbishy

Ikram

et al. 2020

Foods

384

178

View full text Add to dashboard Cite

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“…However, the antifungal activities were lower against Penicillium funiculosum, P. ochrochloron, and Candida albicans. Several reports have indicated that rutoside, quercitrin, protocatechuic acid, and vanillic acid have antifungal activities [3,4,35,36].…”

Section: Discussionmentioning

confidence: 99%

Antiproliferative, Antimicrobial, and Antifungal Activities of Polyphenol Extracts from Ferocactus Species

et al. 2020

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Polyphenols, obtained from natural resources, may possess important pharmacological effects. The polyphenolic profiles of the stem extracts of six Ferocactus species (sp.): F. gracilis, F. pottsii, F. herrerae, F. horridus, F. glaucescens, and F. emoryi, were measured using high-performance liquid chromatography (HPLC) with diode-array detection (DAD). Additionally, anticancer, antibacterial, and antifungal activities were examined. Results showed the presence of high to moderate amounts of polyphenols in the extracts (phenolic acids: Protocatechuic acid, 3,4-dihydroxyphenylacetic acid, caffeic acid, and vanillic acid; flavonoids: Rutoside and quercitrin). The highest amounts of 3,4-dihydroxyphenylacetic acid were found in F. glaucescens ((132.09 mg 100 g−1 dry weight (DW)), F. pottsii (75.71 mg 100 g−1 DW), and F. emoryi (69.14 mg 100 g−1 DW) while rutoside content was highest in F. glaucescens (107.66 mg 100 g−1 DW). Maximum antiproliferative activities were observed against HeLa and Jurkat cancer cells, with F. glaucescens, F. emoryi, and F. pottsii showing the highest anticancer activity. Most bacteria were sensitive to Ferocactus sp. stem extracts. Escherichia coli and Staphylococcus aureus were the most sensitive. Excellent antifungal effects were observed against Aspergillus ochraceus and A. niger. However, Penicillium funiculosum, P. ochrochloron, and Candida albicans were relatively resistant. This is the first study reporting novel sources of polyphenols in Ferocactus sp. with anticancer and antimicrobial activities.

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“…The toxicity tests showed that quercetin protects red blood cells from amphotericin B-mediated hemolysis and toxicity. It was suggested that quercetin and rutin are potential agents to combine with amphotericin B in order to reduce the amphotericin dose to lessen side effects and improve antifungal efficacy (Oliveira et al, 2016). Rutin and aurapten isolated from Polygala paniculata plants common in Brazil has shown antifungal activity against (Johann et al, 2011).…”

Section: Antifungal Propertymentioning

confidence: 99%

A review on the chemistry and biological properties of Rutin, a promising nutraceutical agent

Prasad¹,

Prasad²

2019

Asian J Pharm Pharmacol

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Nature is an attractive source of new therapeutic agents and a variety of phytochemicals have proved to be very valuable in the prevention and treatment of various diseases. Many of the important drugs isolated from plants during the past 50 years have revolutionized modern medicinal practice (Dar et al., 2017). The use of herbal medicines and phytonutrients or nutraceuticals continues to expand rapidly across the world with many people now resorting to these products for the treatment of various health challenges in different national healthcare settings (WHO, 2004). It is estimated that up to 80% of the world's population living in the developing countries rely on herbal medicinal products as a primary source of healthcare and traditional medical practice as an integral part of the culture in their communities (Ekor, 2013). The medicinal compounds derived from various plants could be divided into three major biochemical classes: alkaloids (vinblastine, vincristine, pilocarpine, berberine, caffeine, piperine etc.), flavonoids (quercetin, kaempferol, chrysin, naringenin, genistein, rutin etc.) and terpenoids (artemisinin, taxol, digitoxin, azadarachtin, camphor, limonene etc.) (Takshak, 2018). These compounds have also gained importance in the area of nutraceuticals, which have positive health effects and may prove to be advantageous in the treatment of diseases like cancer, cardiovascular diseases and diabetes (Crozier et

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Quercetin and rutin as potential agents antifungal against Cryptococcus spp

Cited by 72 publications

References 29 publications

The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin

The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin

Antiproliferative, Antimicrobial, and Antifungal Activities of Polyphenol Extracts from Ferocactus Species

A review on the chemistry and biological properties of Rutin, a promising nutraceutical agent

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