Factors associated with acquisition of carbapenem-resistant Enterobacteriaceae

Abstract

Objective:to identify possible risk factors for acquisition of Enterobacterial strains with a marker for resistance to carbapenems. Methods:exploratory case-control study performed in hospital settings. The study sample consisted of patients with biological specimens that tested positive for carbapenem-resistant Enterobacteriaceae (cases), with the disk diffusion test and Etest, and controls with biological samples testing negative for carbapenem-resistant Enterobacteriaceae. In all, 65 patients were included: 13 (20%) cases and 52 (80%) controls. Results:the microorganisms isolated were Serratia marcescens (6), Klebsiella pneumoniae (4), and Enterobacter cloacae (3). Univariate analysis revealed that length of hospitalization prior to sample collection (p=0.002) and having a surgical procedure (p=0.006) were statistically significant. In the multivariable logistic regression model, both were still significant, with odds ratios of 0.93 (p = 0.009; 95% CI: 0.89 to 0.98) for length of hospitalization prior to sample collection, and 9.28 (p = 0.05; 95% CI: 1.01 to 85.14) for having a surgical procedure. Conclusion:shorter hospitalization times and increased surveillance of patients undergoing surgery could play a decisive role in reducing the spread of carbapenem-resistant microorganisms in hospital settings.

Prevalence of New Delhi Metallo-Beta Lactamase Gene among Klebsiella Species Isolates: An Egyptian Study

“…In the current study, comparison between the different hospital departments regarding the isolation of MBL producing strains showed there was no statistically significant difference between the strains (p>0.05). Similar results reported by Lavagnoli et al who observed no association between the acquisition of carbapenemaseproducing Enterobacteriaceae (CPE) and the admission at different hospital departments in a Brazilian study [29]. However, Masaeli and associates, who collected 423 clinical isolates reported that admission to the ICU was a major risk factor for the acquisition of MBL by using univariate analysis [30].…”

Estudo sensorial de bebidas alcoólicas de mangaba (Hancornia speciosa Gomes)

“…No tocante a enterobactérias, verificou-se valores < 1 × 10 2 UFC/mL para todas as formulações de fermentados. As enterobactérias são micro-organismos gram negativos, encontrados na natureza, que têm a capacidade de colonizar o trato gastrointestinal de seres humanos e animais, e dentre essa família encontram-se diversos gêneros, como: Klebsiella, Enterobacter, Escherichia, Serratia, Citrobacter, Salmonella, Proteus e Morganella (Seibert et al, 2014;Lavagnoli et al, 2017), sendo a maioria capaz de causar problemas de saúde ao ser humano se consumidos em quantidades excessivas e/ou se forem consumidas as suas toxinas.…”

Fatores prognósticos de pacientes graves com Klebsiella pneumoniae produtora de carbapenemase

“…Conclusion: Prognostic factors of patients with Klebsiella pneumoniae producing carbapenemase were: PELOD-2 score on the day of infection, 48 hours after infection and on the day of death or hospital discharge; use of parenteral nutrition (PN) seemed to be a protective factor for death. intestinal de animais e seres humanos [9][10] . Sua relevância no ambiente hospitalar está relacionada às infecções da corrente sanguínea, trato urinário, infecções de sítio cirúrgico e pneumonias [9][10] .…”

“…intestinal de animais e seres humanos [9][10] . Sua relevância no ambiente hospitalar está relacionada às infecções da corrente sanguínea, trato urinário, infecções de sítio cirúrgico e pneumonias [9][10] .…”

“…Uma preocupação constante é a aquisição de mecanismos de resistência aos antimicrobianos por parte das enterobactérias, em especial Klebsiella pneumoniae e Enterobacter spp 10,11…”