Rehabilitation Therapy With Insulin-Like Growth Factor After Acute Skeletal Muscle Injury

Wang, Qing; Wang, Fen

doi:10.1590/1517-8692202127032021_0135

Cited by 1 publication

(1 citation statement)

References 5 publications

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“…It has more obvious effect when being used for the treatment of “heel pain” of plantar fasciitis compared with the “local sealing treatment”. Local injection of exogenous insulin-like growth factor-1 (IGF-1) can stimulate the proliferation of myoblasts and accelerate the process of repair ( Wang and Wang, 2021 ). It can be used for the treatment of shoulder arthritis (subacromial and bilateral tendonitis), traumatic or degenerative joint swelling and synovitis, and helps to relieve swelling and pain.…”

Section: The Effects Of Growth Factor Preparationmentioning

confidence: 99%

Feasibility of Growth Factor Agent Therapy in Repairing Motor Injury

Tan

Liu

et al. 2022

Front. Pharmacol.

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Growth factors (GF), with the activity of stimulating cell growth, play a significant role in biology, medicine, and exercise physiology. In the process of exercise, human tissues are impacted, making cells suffer damage. Growth factor can accelerate the repair of damaged cells and regulate the synthesis of protein, so biological preparations of growth factors can be added to traditional therapies. A combination of growth factor biologics and conventional therapies may improve the efficiency of injury repair, but growth factor biologics may not produce any results. The feasibility of growth factor biologics in the treatment of motor injury was discussed. The research have shown that: 1) GF biological agent therapy is a very promising treatment for motor injury, which is based on the power of autologous growth factor (GFs) to accelerate tissue healing, promote muscle regeneration, increase angiogenesis, reduce fibrosis, and make the muscle injury rapid recovery. 2) There are various methods for delivering the higher dose of GF to the injured tissue, but most of them depend on the platelet release of GF. At the site of injury, there are several ways to deliver higher doses of GF to the injured tissue. 3) At present, the inhibition of GF is mainly through signal transduction inhibitors and inhibition of transcription factor production. 4) Pattern of GF during wound repair: GF directly regulates many key steps of normal wound repair, including inflammatory cell chemotaxis, division and proliferation of fibroblasts, keratinocytes and vascular endothelial cells, formation of new blood vessels, and synthesis and degradation of intercellular substances. 5) When GF promotes chronic wound healing, in most cases, certain GF can be used targeted only when in vivo regulation still cannot meet the need for repair.

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Section: The Effects Of Growth Factor Preparationmentioning

confidence: 99%