Muscle Strength, Gh and Igf-1 in Older Women Submitted to Land and Aquatic Resistance Training

Vale, Rodrigo Gomes de Souza; Ferrão, Max Luciano Dias; Nunes, Rodolfo de Alkmim Moreira; Silva, Jurandir Baptista da; Júnior, Rudy José Nodari; Dantas, Estélio Henrique Martín

doi:10.1590/1517-869220172304163788

Cited by 10 publications

(10 citation statements)

References 28 publications

(34 reference statements)

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“…Similar results have been observed with resistance training. A 12-week resistance training intervention in older (mean age > 60 years old) sedentary women resulted in an increase in IGF-1 levels (Vale et al 2017), and increased IGF-1 was positively related with cognitive function in older adults after a 52-week intervention (Tsai et al 2015), and after a 24-week intervention in 62 sedentary elderly (Cassilhas et al 2007a).…”

Section: Exercise-induced Igf-1 Increase In Blood Flow and Cognitionmentioning

confidence: 99%

The role of exercise in the reversal of IGF-1 deficiencies in microvascular rarefaction and hypertension

et al. 2019

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Hypertension has been linked with peripheral and central reductions in vascular density, and with devastating effects on brain function. However, the underlying mechanisms in the relationship between blood pressure and cognitive impairment have yet to be fully elucidated. Here, we review compelling evidence from two lines of inquiry: one that links microvascular rarefaction with insulin-like growth factor 1 (IGF-1) deficiencies, and another which posits that vascular dysfunction precedes hypertension. Based on the findings from experimental and clinical studies, we propose that these lines of evidence converge, and suggest that agerelated declines in IGF-1 concentrations precede microvascular rarefaction, initiate an increase in vascular resistance, and therefore are causally linked to onset of hypertension. Physical exercise provides a relevant model for supporting our premise, given the wellestablished effects of exercise in attenuating vascular dysfunction, hypertension, IGF-1 deficiency, and cognitive decline. We highlight here the role of exerciseinduced increases in blood flow in improving vascular integrity and enhancing angiogenesis via the actions of IGF-1, resulting in reversal of rarefaction and hypertension, and enhancement of cerebral blood flow and cognition.

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Section: Exercise-induced Igf-1 Increase In Blood Flow and Cognitionmentioning

confidence: 99%

The role of exercise in the reversal of IGF-1 deficiencies in microvascular rarefaction and hypertension

et al. 2019

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“…A total of 1066 studies were found (Supplementary Fig. 1), and 179 potentially includable studies were identified through the title and abstract, of which 30 RCTs [17,[23][24][25] met the eligibility criteria and were included in the systematic review; of these, 27 were included in the meta-analysis [17,23,[30][31][32][33][34][35][36][37][38][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55] (3 were excluded because no data were available).…”

Section: Study Selectionmentioning

confidence: 99%

“…A total of 30 RCTs [16,[23][24][25][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] published between 1994 and 2021 involving 1247 subjects (664 women; 53.25%) aged 45 to 92 years were included in the systematic review. The RCTs were conducted in the following continents: Oceania [39], Asia [17,32,33,42,44,48,50], Europe [24,31,41,43,45,46,52] and America [23,25,30,[34][35][36][37][38]40,47,49,[53]…”

Section: Study and Intervention Characteristicsmentioning

confidence: 99%

“…The RCTs were conducted in the following continents: Oceania [39], Asia [17,32,33,42,44,48,50], Europe [24,31,41,43,45,46,52] and America [23,25,30,[34][35][36][37][38]40,47,49,[53][54][55]]. In addition, 22 studies were performed in a healthy population, described as individuals without specific health disorders or pathologies [23,24,[30][31][32][34][35][36][37][38]40,[42][43][44][45][46][47][49][50][51]53,…”

Section: Study and Intervention Characteristicsmentioning

confidence: 99%

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Effects of Resistance Exercise on Neuroprotective Factors in Middle and Late Life: A Systematic Review and Meta-Analysis

Rodríguez‐Gutiérrez¹,

Torres‐Costoso²,

Pascual‐Morena³

et al. 2023

Aging and disease

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Neuroprotective factors are involved in brain functioning. Although physical exercise has been shown to have a positive influence on these factors, the effect of resistance exercise on them is not well known. This systematic review and meta-analysis aimed to 1) estimate the efficacy of resistance exercise on major neuroprotective factors, such as insulin-like growth factor-1 (IGF-1), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF), in middle and late life and 2) determine whether the effect is dose dependent. A systematic search was conducted in CINAHL, Cochrane CENTRAL, MEDLINE, Scopus, PEDro, SPORTDiscus, and Web of Science up to November 2022. Random effects models were used to estimate standardized mean differences (SMDs) and their respective 95% confidence intervals (CI) for the effect of resistance exercise on peripheral IGF-1, BDNF or VEGF levels in older adults. Thirty randomized clinical trials with 1247 subjects (53.25% women, 45-92 years) were included in the systematic review, and 27 were selected for the meta-analysis. A significant effect of resistance exercise on IGF-1 levels was observed (SMD: 0.48; 95% CI: 0.27, 0.69), being more effective when performing 3 sessions/week (SMD: 0.55; 95% CI: 0.31, 0.79) but not on BDNF (SMD: 0.33; 95% CI: -0.29, 0.94). The effect on VEGF could not be determined due to the scarcity of studies. Our data support the resistance training recommendation in middle and late life, at a frequency of at least 3 sessions/week, to mitigate the neurological and cognitive consequences associated with aging, mainly through IGF-1.

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“…Maiores níveis de IGF-1 trazem benefícios a idosas, sendo relevante o conhecimento de meios que aumentem sua síntese e liberação Oliveira et al, 2003). O treinamento de força auxilia no incremento dos níveis hormonais de IGF-1 (Vale et al, 2017a;Vale & Rodrigues, 2014;Bastos et al, 2013;Vale et al, 2009). Os exercícios no meio aquático podem ser uma alternativa aos exercícios terrestres, apresentando menos estresse nas articulações e menor risco de quedas quando comparado ao ambiente terrestre (Hale, Waters, & Herbison, 2012).…”

Section: Introductionunclassified

Análisis de correlación entre fuerza muscular, IGF-1 y autonomía funcional en ancianas con exceso de peso sometidas a ejercicios resistidos acuáticos

Castro¹,

Brum²,

Pernambuco³

et al. 2019

RIAA

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Contexto: Dentre as alterações orgânicas que tendem a ocorrer com o envelhecimento, tem-se a redução da força muscular, dos níveis séricos de IGF-1 e da autonomia funcional (AF). Contudo, esses efeitos deletérios podem ser amenizados por meio da prática de exercícios físicos, como a hidroginástica.Objetivos: Analisar a correlação entre força muscular, IGF-1, IGFBP3 e AF em idosas com excesso de peso submetidas a exercícios resistidos aquáticos.Método: A amostra foi composta por 14 idosas (idade: 68,93 ± 4,46 anos; IMC: 28,55 ± 2,08 kg/m2) submetidas a exercícios resistidos aquáticos durante 12 semanas. A intervenção ocorreu 3 vezes por semana, com 50 minutos por sessão de treinamento. A força muscular foi mensurada através de dinamometria, incluindo força de membros inferiores e de preensão palmar direita (FMD) e esquerda (FME). A coleta de sangue para análise do IGF-1 e seu principal carreador, o IGFBP3, foi realizada através do método quimioluminescência. A AF foi avaliada por meio do protocolo de autonomia GDLAM.Resultados: O teste de correlação de Pearson apresentou correlação (r) positiva e significativa entre FMD e FME, FMD e IGF1, FMD e IGFBP3, FME e IGF1, FME e IGFBP3, e IGF1 e IGFBP3.Conclusoes: A prática de exercícios resistidos aquáticos pode melhorar os níveis de força muscular de preensão manual, de IGF1 e de IGFBP3 em idosas com excesso de peso.

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Muscle Strength, Gh and Igf-1 in Older Women Submitted to Land and Aquatic Resistance Training

Cited by 10 publications

References 28 publications

The role of exercise in the reversal of IGF-1 deficiencies in microvascular rarefaction and hypertension

The role of exercise in the reversal of IGF-1 deficiencies in microvascular rarefaction and hypertension

Effects of Resistance Exercise on Neuroprotective Factors in Middle and Late Life: A Systematic Review and Meta-Analysis

Análisis de correlación entre fuerza muscular, IGF-1 y autonomía funcional en ancianas con exceso de peso sometidas a ejercicios resistidos acuáticos

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