Telomere length and childhood trauma in Colombians with depressive symptoms

Jiménez, Karen M.; Pereira-Morales, Angela J.; Adán, Ana; Forero, Diego A.

doi:10.1590/1516-4446-2018-0027

Cited by 11 publications

(8 citation statements)

References 36 publications

(48 reference statements)

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“…Similarly, in a prospective experimental study in humans, Epel et al (2010) (54) reported increased telomerase activity with greater cortisol level in response to stressors. Jimenez et al (2018) (55) found a positive correlation between T/S ratio and sexual abuse scores in depressive individuals in Latin America.…”

Section: Discussionmentioning

confidence: 97%

Leukocyte Telomere Length Is Not Shortened in Methamphetamine Dependence or Methamphetamine-Induced Psychosis but Is Increased Following Traumatic Events.<strong> </strong>

Rungnirundorn¹,

Krusong²,

Kalayasiri³

et al. 2021

Preprint

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Background: Methamphetamine (MA) is one of the most common drugs of abuse in Thailand. MA use may cause neurotoxicity, immune-inflammatory and oxidative stress responses and, consequently, MA-induced psychosis (MIP).Aims: This study aims to examine the effects of MA use and dependence and MA withdrawal symptoms on the telomere to single copy gene (T/S) ratio and whether shortening of the latter is associated with MIP.Methods: This study included 185 MA-abuse, 118 MA-dependent, and 67 MIP patients, diagnosed using DSM-IV-TR criteria. The Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA) questionnaire was employed to collect clinical and MA-related data. MIP was confirmed using the Methamphetamine Experience Questionnaire (MEQ). The leukocyte telomere length was measured in all participants using real-time polymerase chain reaction measuring the Telomere/Single gene ratio (T/S ratio). Results: There were no significant associations between the T/S ratio and severity of MA-use, MIP, MA withdrawal symptoms including depression and psychomotor retardation. MIP was significantly predicted by alcohol dependence, antisocial personality disorder, and MA-use severity. There were significant and positive associations between the T/S ratio and previous traumatic events and life-threatening accidents. The T/S ratio was not affected by comorbid alcohol and nicotine dependence. Alcohol and nicotine dependence, antisocial personality, and severity of MA use increased risk of MA withdrawal symptoms. Conclusion: MIP and MA-use severity do not affect leukocyte telomere length, but telomere length may be affected by previous traumatic events and life-threatening accidents.

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Section: Discussionmentioning

confidence: 97%

Leukocyte Telomere Length Is Not Shortened in Methamphetamine Dependence or Methamphetamine-Induced Psychosis but Is Increased Following Traumatic Events.<strong> </strong>

Rungnirundorn¹,

Krusong²,

Kalayasiri³

et al. 2021

Preprint

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“…These infrastructural and logistical requirements are difficult to satisfy when working in settings without extensive medical and laboratory facilities. The few TL studies that have been conducted in LMIC have been mostly limited to hospitals, universities, or other high‐resource settings (eg, Auld et al, 2016; Chatterjee et al, 2015; Eisenberg, Lee, Rej, Hayes, & Kuzawa, 2019; Farrukh, Baig, Hussain, Shahid, & Khan, 2019; Farrukh, Baig, Hussain, & Lucky, 2019; Jiménez, Pereira‐Morales, Adan, & Forero, 2019; Malan, Hemmings, Kidd, Martin, & Seedat, 2011; Oliveira et al, 2018; Pathai et al, 2013; Rej et al, 2019; Tennyson et al, 2018; Von Känel, Malan, Hamer, & Malan, 2015; but see Zahran, Snodgrass, Maranon, Upadhyay, Granger, & Bailey, 2015).…”

Section: Introductionmentioning

confidence: 99%

Telomere length analysis from minimally‐invasively collected samples: Methods development and meta‐analysis of the validity of different sampling techniques

Rej

Bondy

Lin

et al. 2020

American J Hum Biol

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Objectives Telomeres are the protective caps of chromosomes. They shorten with cell replication, age, and possibly environmental stimuli (eg, infection and stress). Short telomere length (TL) predicts subsequent worse health. Although venous whole blood (VWB) is most commonly used for TL measurement, other, more minimally invasive, sampling techniques are becoming increasingly common due to their field‐friendliness, allowing for feasible measurement in low‐resource contexts. We conducted statistical validation work for measuring TL in dried blood spots (DBS) and incorporated our results into a meta‐analysis evaluating minimally invasive sampling techniques to measure TL. Methods We isolated DNA extracts from DBS using a modified extraction protocol and tested how they endured different shipping conditions and long‐term cryostorage. We then included our in‐house DBS TL validation statistics (correlation values with VWB TL and age) in a series of meta‐analyses of results from 24 other studies that published similar associations for values between TL measured in DBS, saliva, and buccal cells. Results Our modified DBS extraction technique produced DNA yields that were roughly twice as large as previously recorded. Partially extracted DBS DNA was stable for 7 days at room temperature, and still provided reliable TL measurements, as determined by external validation statistics. In our meta‐analysis, DBS TL had the highest external validity, followed by saliva, and then buccal cells—possibly reflecting similarities/differences in cellular composition vs VWB. Conclusions DBS DNA is the best proxy for VWB from the three minimally‐invasively specimen types evaluated and can be used to expand TL research to diverse settings and populations.

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“…Aligned with this important field and its numerous challenges, the Brazilian Journal of Psychiatry has endorsed articles covering “glocal” psychiatric epidemiological research in Brazil and Latin America. Substance use-related disorders,4 the impact of violence and early traumatic experiences on mental health outcomes,5 and health services utilization6 are some of the themes covered in this issue. Psychometric evaluation of screening instruments is also discussed in a number of articles, highlighting the importance of using proper instruments, adequately tested for specific populations, in specific cultural contexts.…”

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confidence: 99%

“…This partially explains the growing importance of the Brazilian Journal of Psychiatry in the international context. The articles published in this issue represent a wide variety of countries, such as Argentina,8 Colombia,5 and Iran 9. The high quality of the work carried out by the editorial staff and reviewers is being recognized, and the vocation of the Brazilian Journal of Psychiatry as a regional leader, championing local articles with global implications – hence the term glocal used in our title – becomes increasingly evident.…”

mentioning

confidence: 99%