The 500th Lung Transplantation at the Faculdade de Medicina da Universidade de São Paulo: Reflecting on Our Journey and Looking Ahead

Reis, Flávio Pola dos; Pêgo-Fernandes, Paulo Manuel

doi:10.1590/1516-3180.2023.1414030423

Cited by 1 publication

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“…Organ harvesting occurs mainly from donors diagnosed with brain death (BD). However, the BD process triggers haemodynamic and hormonal cascades and an intense inflammatory process that can impair the function and quality of the lungs, impacting the survival of the transplant patient 1 – 4 .…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of thalidomide in an experimental lung donor model of brain death

Sana Vilela,

Andrighetti de Oliveira Braga,

Moreira Ruiz

et al. 2024

Sci Rep

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Lung transplantation stands as a vital treatment for severe lung diseases, primarily sourcing organs from donors with brain death (BD). This research delved into the potential anti-inflammatory effects of thalidomide in rats with BD-induced lung complications. In this study twenty-four Wistar rats were divided into three groups: the control (CTR), brain death (BD) and brain death + thalidomide (TLD) groups. Post specific procedures, a 360 min monitoring period ensued. Comprehensive analyses of blood and heart-lung samples were conducted. Elevated IL-6 levels characterized both BD and TLD groups relative to the CTR (p = 0.0067 and p = 0.0137). Furthermore, TNF-α levels were notably higher in the BD group than both CTR and TLD (p = 0.0152 and p = 0.0495). Additionally, IL-1β concentrations were significantly pronounced in both BD and TLD compared to CTR, with the BD group surpassing TLD (p = 0.0256). Immunohistochemical assessments revealed augmented NF-ĸB expression in the BD group in comparison to both CTR and TLD (p = 0.0006 and p = 0.0005). With this study we can conclude that BD induced acute pulmonary inflammation, whereas thalidomide manifested a notable capability in diminishing key inflammatory markers, indicating its prospective therapeutic significance in lung transplantation scenarios.

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Section: Introductionmentioning

confidence: 99%