Validation of single measurement of 12-hour urine excretion for estimation of sodium and potassium intake. A longitudinal study

Molina, Maria del Carmen Bisi; Pereira, Taísa Sabrina Silva; Porto, Aline Silva; Silva, Raiane Pereira; Santana, Nathália Miguel Teixeira; Cadê, Nágela Valadão; Mill, José Geraldo

doi:10.1590/1516-3180.2017.0210031117

Cited by 7 publications

(7 citation statements)

References 16 publications

(8 reference statements)

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“…[10] Although urinary excretion is a point marker of these electrolyte, [47] a study conducted by our research group shows that urinary 12-hour sodium and potassium excretion can be considered as an estimate of habitual intake for the population, since there was no variation in measurements performed over a year-long period. [22] Errors of urine collection, if occurred, would tend to bias any observed association between Na/K ratio with SBP or DBP toward the null rather than create a spurious relationship.…”

Section: Discussionmentioning

confidence: 99%

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Effect of urinary sodium-to-potassium ratio change on blood pressure in participants of the longitudinal health of adults study - ELSA-Brasil

et al. 2019

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To assess the effect of changing the sodium to potassium (Na/K) ratio on blood pressure at 4 years of follow-up. The measurements were carried out under identical conditions in two study periods (2008–2010 and 2012–2014). Urinary excretion of sodium and potassium (mmol/L) over 12 nocturnal hours was used to calculate the Na/K ratio and categorized by quintile. The 24-hour sodium and potassium intake was estimated using a validated equation. The mean BP was calculated from 3 measurements after 5 minutes of rest. Of the 15,105 participants at baseline, 14,014 completed the first follow-up. Participants without validated urine collection (n = 5,041), using antihypertensive medication (n = 3,860) at either time points or reporting bariatric surgery during follow-up (n = 45) were excluded. The differences between follow-up and baseline values were calculated for BP and the Na/K ratio. Analyses were stratified by sex and adjusted for confounding variables. Sodium intake did not change from baseline, but potassium intake increased by approximately 150 mg in both sexes ( P < .001), with a consequent reduction of the Na/K ratio. The highest quintile of change in the Na/K ratio was associated with greater variation in BP. When adjusted for covariates, it is possible to observe an increase in SBP in women from the third quintile of the Na/K ratio, in men this increase was observed from the fourth quintile. However, for DBP this increase is observed from the third quintile in both men and women. Increase in SBP was observed in women from the third quintile of the Na/K ratio, in men this increase is observed from the fourth quintile. However, for DBP this increase is observed from the third quintile in both men and women. The Na/K ratio demonstrated a greater association in BP.

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Section: Discussionmentioning

confidence: 99%

“…[21] The 12-hour urinary may be used in epidemiological studies because it reliably estimates the habitual consumption of sodium and potassium since good agreement was observed among the 5 measurements evaluated over a one year (sodium ICC 0.65, P < .001; potassium ICC 0.54, P < .001). [22]…”

Section: Methodsmentioning

confidence: 99%

Effect of urinary sodium-to-potassium ratio change on blood pressure in participants of the longitudinal health of adults study - ELSA-Brasil

et al. 2019

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“…The work carried out by our research group has shown that only a measure taken over a year can accurately estimate the usual consumption of sodium and potassium. 20 Therefore, the Na/K ratio will be used as a marker of change in the consumption of sodium, potassium or both before and after the intervention.…”

Section: Evaluation Of Sodium Potassium and Sodium/potassium Ratio Consumptionmentioning

confidence: 99%

Impact of the training of community health workers on food education: methodological aspects and potentialities / Impacto da capacitação de agentes comunitários de saúde em educação alimentar: aspectos metodológicos e potencialidades

Molina

Martins

Siqueira

et al. 2021

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Objetivo: analisar os aspectos metodológicos e as potencialidades do estudo “Impacto da capacitação de Agentes Comunitários de Saúde (ACS) em educação alimentar (EA) - Vitória/ES”. Métodos: os ACS de 25 Unidades de Saúde (US) foram convidados e avaliados em Centro de Investigação Cardiovascular. Foram realizadas quatro etapas: Avaliação da saúde e nutrição dos ACS; Estudo qualitativo; Capacitação em EA; Reavaliação. Resultados: foram coletados dados bioquímicos e antropométricos, de consumo alimentar, exames clínicos, eletrólitos urinários e testes físicos. Estudo qualitativo realizado para levantamento da percepção dos ACS sobre o estudo. As US foram randomizadas em dois grupos (intervenção e controle). O grupo intervenção participou de uma capacitação em EA, tendo como base o Guia Alimentar para a População Brasileira. Ao final da capacitação, os ACS foram reavaliados para identificar mudanças nas condições de saúde. Conclusão: este estudo pode contribuir para o planejamento, monitoramento e avaliação de ações específicas na atenção primária.

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“…To overcome the 24-h urine collection, some trials tried to estimate the potassium-diet intake with spot urine collection and dietary questionnaires. Unfortunately, this method (estimation of 24-h urinary potassium excretion from a urine spot) failed to be reliable for individual estimates [20][21][22]. The KDOQI guidelines suggest that methods for assessing dietary intakes should be simplified to obtain reliable data on dietary intakes and ensure that they are culturally appropriate.…”

Section: Introductionmentioning

confidence: 99%

Prediction Tool to Estimate Potassium Diet in Chronic Kidney Disease Patients Developed Using a Machine Learning Tool: The UniverSel Study

et al. 2022

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There is a need for a reliable and validated method to estimate dietary potassium intake in chronic kidney disease (CKD) patients to improve prevention of cardiovascular complications. This study aimed to develop a clinical tool to estimate potassium intake using 24-h urinary potassium excretion as a surrogate of dietary potassium intake in this high-risk population. Data of 375 adult CKD-patients routinely collecting their 24-h urine were included to develop a prediction tool to estimate potassium diet. The prediction tool was built from a random sample of 80% of patients and validated on the remaining 20%. The accuracy of the prediction tool to classify potassium diet in the three classes of potassium excretion was 74%. Surprisingly, the variables related to potassium consumption were more related to clinical characteristics and renal pathology than to the potassium content of the ingested food. Artificial intelligence allowed to develop an easy-to-use tool for estimating patients’ diets in clinical practice. After external validation, this tool could be extended to all CKD-patients for a better clinical and therapeutic management for the prevention of cardiovascular complications.

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Validation of single measurement of 12-hour urine excretion for estimation of sodium and potassium intake. A longitudinal study

Cited by 7 publications

References 16 publications

Effect of urinary sodium-to-potassium ratio change on blood pressure in participants of the longitudinal health of adults study - ELSA-Brasil

Effect of urinary sodium-to-potassium ratio change on blood pressure in participants of the longitudinal health of adults study - ELSA-Brasil

Impact of the training of community health workers on food education: methodological aspects and potentialities / Impacto da capacitação de agentes comunitários de saúde em educação alimentar: aspectos metodológicos e potencialidades

Prediction Tool to Estimate Potassium Diet in Chronic Kidney Disease Patients Developed Using a Machine Learning Tool: The UniverSel Study

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