Characterization of Calcium Aluminate Cement Phases when in Contact with Simulated Body Fluid

Oliveira, I. R.; Andrade, Talita Luana de; Parreira, Renata Martins; Jacobovitz, Marcos; Pandolfelli, V. C.

doi:10.1590/1516-1439.336714

Cited by 18 publications

(14 citation statements)

References 20 publications

(34 reference statements)

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“…While no Ca was detected in EBZnO group, the element P (phosphorus) was identified in all the groups containing the EndoBinder extracts. The mere presence of P indicates the Ca presence , even though this is not detected by SEM/ EDS, due to the formation of a calcium phosphate phase in the extracts, which in turn, constituted an indicator of the material bioactivity (25). The bioactivity of a material is defined as the capacity to promote a local response when in contact with a living tissue and generate an interface chemical bond (4).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

et al. 2017

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This study aimed to evaluate the cytotoxicity of a calcium aluminate cement (EndoBinder) containing different radiopacifiers, Bi 2 O 3 , ZnO or ZrO 2 , compared with Mineral Trioxide Aggregate (MTA). According to ISO 10993-12:2012 (E) recommendations, 0.2 g of each cement were applied in transwell inserts and placed in 24-well culture plates containing 1 mL of culture medium (DMEM). After 24 h of incubation, the extracts (DMEM containing components released from the cements) were applied to immortalized odontoblast-like MDPC-23 cells. Cell viability (MTT test), alkaline phosphatase activity (ALP), total protein production and cell morphology (Scanning Electron Microscopy -SEM) were evaluated. The volume of 50 µL of extract was used to determine the chemical elements released by the cements using Energy Dispersive Spectroscopy (EDS). The following groups were established (n=6): NC -negative control (without treatment); EB -EndoBinder without radiopacifier; EBBO -EndoBinder+Bi 2 O 3 ; EBZnO -EndoBinder+ZnO; EBZrOEndoBinder+ZrO 2 and WMTA -White MTA. Data were subjected to statistical analysis (Kruskal-Wallis test, level of significance=5%). Cells exposed to the different versions of EndoBinder presented small reduction in viability, total protein production and ALP activity, with values similar to the NC and WMTA groups (p>0.05). Different elements (C, O, Na, Al, P, Si, Cl, Bi, K) released by the cements were detected in the extracts. However, the cells had no significant changes in their morphology. EndoBinder and MTA did not affect negatively the metabolism of the odontoblastic-like cells, showing it to be cytocompatible, irrespective of the used radiopacifier.

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

et al. 2017

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“…Additionally, similar to MTA, CAC is bioactive in contact with simulated body fluid (SBF) (Oliveira et al . ), although this cement has reached lower pH and calcium release compared with MTA (Pandolfelli et al . , Oliveira et al .…”

Section: Introductionmentioning

confidence: 99%

“…Studies have shown that CAC has the same satisfactory properties that allow MTA to be used in many endodontic procedures (Torabinejad & Chivian 1999, Jacobovitz et al 2009, Oliveira et al 2010. Additionally, similar to MTA, CAC is bioactive in contact with simulated body fluid (SBF) (Oliveira et al 2015), although this cement has reached lower pH and calcium release compared with MTA (Pandolfelli et al 2007, Oliveira et al 2010.…”

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confidence: 99%

Calcium chloride‐enriched calcium aluminate cement promotes in vitro osteogenesis

et al. 2018

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“…In especially the calcium aluminate CaO•Al 2 O 3 is a ceramic material with a considerable importance due to its several applications, such as a refractory material (Miranda Hernández et al, 2018), concrete-based calcium aluminate cement (Scrivener et al, 1999), catalyst (Zabeti et al, 2009), and metallurgical processes (Jiangling et al, 2015;Jifang et al, 2012Jifang et al, , 2016. Also, this material has been studied for biomedical applications (Regina de Oliveira et al, 2015), such as in odontology (Leal Silva et al, 2014;Engqvist et al, 2004;Parreira et al, 2016;Loof et al, 2003;Oliveira et al, 2010;Andrade et al, 2014), bone replacement (Uchida et al, 1984) and bone-graft applications (Kalita et al, 2002;Hulbert et al, 1970). As well, calcium aluminate has been the focus of several studies about of the synthesis processes, such as the sol-gel method (Aitasalo et al, 2002), solid state reaction (Miranda Hernández et al, 2018;Aitasalo et al, 2002;Yongpan et al, 2016), sintering (Miranda Hernández et al, 2018;Iftekhar et al, 2008;, mechanochemical synthesis (Wieczorek-Ciurowa et al, 2010), and the sonochemical process (Lourençoa et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…The synthesis of this material considers the obtaining of CaCO 3 from snail shells as a source of CaO to get calcium aluminates (Miranda Hernández et al, 2018;Aitasalo et al, 2002;Galan et al, 2013;Singh and Purohit, 2010;Viriya et al, 1016). On the other hand, the selection of Al and Ag as reinforcement metals in the ceramic matrix has two intentions; the first, it is to study the effect of the metallic particles on the microstructure and its mechanical properties, such as hardness, fracture toughness, and shear modulus considering that Al and Ag are ductile and malleable metals; the second, is a study of the biological behavior considering some medical application principally as dentistry material (Regina de Oliveira et al, 2015;Leal Silva et al, 2014;Engqvist et al, 2004;Oliveira et al, 2010;Andrade et al, 2014;Aguilar et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Physical, mechanical properties and antimicrobial analysis of a novel CaO·Al2O3 compound reinforced with Al or Ag particles

Saravia

Rastelli

Ortega-Avilés

et al. 2019

Journal of the Mechanical Behavior of Biomedical Materials

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Ceramic-metal (CaO•Al 2 O 3-Al and CaO•Al 2 O 3-Ag) compounds were prepared by mechanical milling and consolidated through an in-situ sintering process. The aim of this work is to study the effects of the Al and Ag particles to ceramic-base compound, primarily in the microstructure, and its mechanical and antimicrobial properties. Chemical systems with a 1:1 M ratio between CaCO 3 and Al 2 O 3 powder were formed, with the addition of 10 wt% Al or 10 wt% Ag, respectively. The compound material that consolidated were microstructurally characterized through X-ray diffraction, scanning electron microscopy, optic microscopy, and X-ray computed tomography. In addition, the hardness, the fracture toughness, the transversal elastic modulus, and the antimicrobial property were evaluated. The results of X-ray diffraction identified the formation of the calcium aluminate phases, such as CaO•6Al 2 O 3 (hibonite:CA6), CaO•2Al 2 O 3 (grossite:CA2), and CaO•Al 2 O 3 (krotite:CA); as well as Al and Ag were identified in its respective system. In addition, the mechanical properties show changes compared to the reference material that was synthesized under the same conditions and, finally, these materials also have an antimicrobial effect, against the Staphylococcus bacterium that is common in the oral cavity, when studied in synthetic saliva.

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Characterization of Calcium Aluminate Cement Phases when in Contact with Simulated Body Fluid

Cited by 18 publications

References 20 publications

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

Cytotoxicity of New Calcium Aluminate Cement (EndoBinder) Containing Different Radiopacifiers

Calcium chloride‐enriched calcium aluminate cement promotes in vitro osteogenesis

Physical, mechanical properties and antimicrobial analysis of a novel CaO·Al2O3 compound reinforced with Al or Ag particles

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