Agreement assessment between hemoglobin and hematocrit to detect anemia prevalence in children less than 5 years old

Brunken, Gisela Soares; França, Giovanny Vinícius Araújo de; Luiz, Ronir Raggio; Szarfarc, Sophia Cornblüth

doi:10.1590/1414-462x201600010x01

Cited by 9 publications

(8 citation statements)

References 15 publications

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“…Despite hemoglobin level being a more common marker of anemia, it is not collected by the ACS-NSQIP, and we had to rely on HCT as a surrogate marker of anemia, which has been commonly done 49 - 52 . The difference in reliability between hemoglobin and HCT in quantifying anemia is, however, minimal 53 . Furthermore, HCT level may also be less susceptible to the dilutional effect of fluid resuscitation 54 , 55 .…”

Section: Discussionmentioning

confidence: 99%

Anemia at Presentation Predicts Acute Mortality and Need for Readmission Following Geriatric Hip Fracture

et al. 2020

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Background: There is a paucity of research regarding the relationship between anemia and postoperative morbidity and mortality among geriatric patients presenting with hip fracture. The objective of this study was to determine the effect of anemia at presentation on 30-day morbidity and mortality among geriatric patients with hip fracture. Methods: The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was queried for all hip fracture patients ≥60 years old from 2011 to 2016. Included were all emergency unilateral, nonpathological hip fractures (femoral neck, intertrochanteric, or subtrochanteric) treated with arthroplasty, intramedullary nailing, or open reduction and internal fixation. Anemia was classified as a hematocrit (HCT) level of <0.41 and <0.36 for male and female patients, respectively. Age, body mass index (BMI), race, comorbidities, smoking status, American Society of Anesthesiologists (ASA) class, baseline functional status, time to surgery, operative time, anesthesia type, need for transfusion, fixation method, length of stay (LOS), and discharge destination were collected. Our primary outcome of interest was 30-day postoperative mortality, with all-cause readmission and any postoperative ischemic events (cerebrovascular accident [CVA] and myocardial infarction [MI]) analyzed as secondary outcomes. A multivariable regression analysis was performed and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated while controlling for confounding variables. Results: Of 34,805 patients identified, 22,469 (65%) were anemic at presentation (63% female; mean age, 80 ± 8 years), while 12,336 (35%) were non-anemic (85% female; mean age, 79 ± 8 years). Anemia at presentation was independently associated with higher odds of mortality (OR,1.3 [95% CI, 1.1 to 1.5]) and readmission (OR, 1.2 [95% CI, 1.1 to 1.3]), while no relationship was observed for MI (OR, 1.1 [95% CI, 0.9 to 1.4]) or CVA (OR, 0.8 [95% CI, 0.6 to 1.1]). Conclusions: Our findings suggest that anemia at presentation is associated with greater 30-day postoperative morbidity and mortality in geriatric hip fracture patients. Additional research should focus on elucidating this modifiable risk factor and advancing the preoperative optimization of hip fracture patients. Level of Evidence: Prognostic Level IV . See Instructions for Authors for a complete description of levels of evidence.

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Section: Discussionmentioning

confidence: 99%

Anemia at Presentation Predicts Acute Mortality and Need for Readmission Following Geriatric Hip Fracture

et al. 2020

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“…A decrease in RBC in the blood is often associated with the development of malnutrition and anemia. Low HGB levels can be due to blood loss, and low Hct levels are often due to anemia [41, 42]. As previously mentioned, BUN and Cre serum levels are commonly used as indicators of kidney function.…”

Section: Discussionmentioning

confidence: 99%

Water Extract of Acori Graminei Rhizoma Attenuates Features of Rheumatoid Arthritis in DBA/1 Mice

Nho

Kim

Jung

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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The dry rhizome of Acorus gramineus Solander, known as Acori Graminei Rhizoma, is used to treat dementia, stroke, eczema, and indigestion in traditional Chinese medicine, traditional Korean medicine, and traditional Japanese Kampo medicine. Previous studies have reported that Acori Graminei Rhizoma extract ameliorated cognitive impairment in Aβ1-42 injected mice. However, the effect of Acori Graminei Rhizoma on type II collagen induced arthritis (CIA) has not been elucidated. Thus, we evaluated the water extract of Acori Graminei Rhizoma (WAG) in CIA mice models. Male DBA/1 mice were separated into five groups (NOR; n=10, CON; n=10, CIA + methotrexate (MTX); n=10, CIA + 100 mg/kg WAG; n=10, CIA + 500 mg/kg WAG; n=10). CIA was induced by injecting the mice with bovine type II collagen, after which the mice were treated with WAG and/or MTX. Hematological parameters and liver and kidney serum toxicity markers were analyzed. Further, serum levels of interleukin (IL)-6, TNF-α, and type II collagen IgG were analyzed via enzyme-linked immunosorbent assay (ELISA). Treatment with 500 mg/kg WAG decreased serum levels of IL-6, TNF-α, and collagen IgG in a CIA model. Moreover, WAG treatment decreased CIA-induced swelling of mouse hind legs, infiltration of inflammatory cells into the synovial membrane, and blood neutrophil levels. WAG administration did not influence hematological parameters or kidneys and liver toxicity markers. WAG may be used to treat arthritis by reducing the inflammation indicators. However, further experiments are required to determine how WAG affects inflammation mechanisms in vitro and in vivo.

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“…It requires a simple and short training period to operate, as well as a stable power source. It requires about 0.5 µL of blood, equivalent to a drop, extracted in a capillary tube, closed at one end and centrifuged (29).…”

Section: Methodsmentioning

confidence: 99%

“…There is a standard conversion between the two measures (Hb = Ht/3) which is commonly used to define cut-off points for estimating the prevalence of anemia. Health services have been using this indicator for anemia screening, since it is less expensive and more practical, but reliability studies are needed (29). The samples were categorized, according to the protocol of the World Health Organization (WHO, 2001) (30), as anemic (Hct < 0.33 g/%) and non-anemic (Hct ≥ 0.33 g/%) pregnant women using conventional conversion factors (29).…”

Section: Methodsmentioning

confidence: 99%

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Comparison of glucose measurement on dried blood spots versus plasma samples in pregnant women with and without anemia

Matos

Moreira

Luiz

et al. 2020

Archives of Endocrinology and Metabolism

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Objective: Compare the concordance degree between plasma glucose and glucose measurements on Dried Blood Spots (DBS) during pregnancy. Subjects and methods: Glucose measurement was performed in pregnant women after a fast of 8-12 hours. Venous blood was collected with sodium fluoride, the plasma was separated, and glucose measured by the enzymatic oxidase glucose method. Capillary blood samples were collected and analyzed by DBS. For statistics, the paired Student's t test, interclass correlation coefficient (ICC), graphic approach of Altman and Bland, and survival-concordance plot were used. Results: 307 pregnant women were evaluated, 88.6% without diabetes and 11.4% with previous diabetes. The glucose ranged from 66 to 190 mg/dL [3.66 to 10.55 mmol/L] in plasma and from 53 to 166 mg/dL [2.94 to 9.21 mmol/L] in DBS. The glucose average values were 88.1 ± 12 mg/dL [4.98 ± 0.67 mmol/L] in plasma and 89.2 ±11,5 mg/dL, [4.95 ± 0.64 mmol/L] in DBS-p-value = 0.084. The ICC value was moderate (0.510), and Pearson's correlation coefficient was r = 0.507 p < 0.001. Altman and Bland's graph showed that difference between the values obtained by both methods is-24.62 to 22.3 mg/dL [-1.37 to 1.24 mmol/L]. Significant fixed bias (-1,16 average difference) and proportional bias (r = 0.056; p = 0.33) were not observed. Anemia was associated with differences between plasma glucose and DBS measurements (p = 0.031). Conclusion: Capillary glucose in DBS correlates with plasma glucose; however, the methods do not present good concordance. The presence of anemia worsens this result.

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Agreement assessment between hemoglobin and hematocrit to detect anemia prevalence in children less than 5 years old

Cited by 9 publications

References 15 publications

Anemia at Presentation Predicts Acute Mortality and Need for Readmission Following Geriatric Hip Fracture

Anemia at Presentation Predicts Acute Mortality and Need for Readmission Following Geriatric Hip Fracture

Water Extract of Acori Graminei Rhizoma Attenuates Features of Rheumatoid Arthritis in DBA/1 Mice

Comparison of glucose measurement on dried blood spots versus plasma samples in pregnant women with and without anemia

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