The essential oil of Hyptis crenata Pohl ex Benth. presents an antiedematogenic effect in mice

Abstract

Hyptis crenata , commonly known as “salva-do-Marajó”, “hortelã-do-campo”, and “hortelãzinha”, is used in folk medicine in Northeast Brazil as tea or infusion to treat inflammatory diseases. Due to the pharmacological efficacy and the low toxicity of the essential oil of Hyptis crenata (EOHc), we decided to investigate the EOHc antiedematogenic effect in experimental models of inflammation. EOHc was administrated orally at doses of 10-300 mg/kg to male Swiss albino mice. Paw edema was induced by subcutaneous injection in the right hind paw of inflammatory stimuli (carrageenan, dextran, histamine, serotonin, and bradykinin) 60 min after administration of EOHc. EOHc significantly inhibited the induced edema. The inhibitory effect of EOHc on dextran-induced edema extended throughout the experimental time. For the 30, 100, and 300 mg/kg doses of EOHc, the inhibition was of 40.28±1.70, 51.18±2.69, and 59.24±2.13%, respectively. The EOHc inhibitory effect on carrageenan-induced edema started at 10 mg/kg at the second hour (h) and was maintained throughout the observation period. At 30, 100, and 300 mg/kg doses the inhibition started earlier, from 30 min. At the edema peak of 180 min, 56, 76, and 82% inhibition was observed for 30, 100, and 300 mg/kg doses, respectively. Additionally, the effect of EOHc on carrageenan-induced paw edema was influenced by the time of administration. The EOHc also inhibited myeloperoxidase activity. In conclusion, the EOHc showed a potent effect, both preventing and reversing the edema, consistent with its anti-inflammatory use in folk medicine.

Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil

“…Coelho-de-Souza et al. (2021) also demonstrated that the essential oil of H. crenata has an anti-edematogenic effect in different models of paw edema, attributing these actions to the presence of 1,8-cineole [40] .…”

“…In this context, in the Lamiaceae family, there are a plethora of species with rich content in essential oils, which are used in popular medicine as an alternative treatment for diseases [2] . For example, the genus Hyptis is considered of great economic importance since it is composed of triterpenes [3] , diterpenes [4] and sesquiterpenes [5] , that are responsible for interesting antimicrobial [ 6 , 7 ], insecticide [8] , analgesic [9] , [10] , [11] , and hypnotic-sedative and antipsychotic-like activity [12] .…”

“…The species Hyptis martiusii Benth. is popularly known as “cidreira do campo” or “cidreira brava”, and is characterized by a shrub species is found in the North, Southeast, and Northeast regions of Brazil [11] . In the literature, their insecticide [8] , genotoxic [13] , anti-ulcerogenic [ 14 , 15 ], antiedematogenic [10] , antibacterial with anti-staphylococcal [16] , antifungal [6] and hypnotic-sedative and antipsychotic-like activity [12] effects have been listed.…”

Minerals, Essential Oils, and Biological Properties of Melissa officinalis L.

“…The edible, scented and functional properties of M. officinalis make it a plant of choice for application in food and pharmaceutical industries. M. officinalis extract is medicinal and most countries use it in their traditional systems of medicine to treat many diseases [8][9][10][11][12][13].…”

“…The edible, scented and functional properties of M. officinalis make it a plant of choice for application in food and pharmaceutical industries. M. officinalis extract is medicinal and most countries use it in their traditional systems of medicine to treat many diseases [8][9][10][11][12][13]. In Algeria, M. officinalis is used as integrated pharmaceutical treatment option for the treatment of headache, indigestion, abdominal cramps, heart failure, diabetes and bacterial viral infections [1,14].…”