Effect of Camellia sinensis teas on left ventricular hypertrophy and insulin resistance in dyslipidemic mice

Ferreira, M.C.L.; Lima, Larissa Nobre de; Cota, Luiz Henrique Torres; Costa, Matheus B. P. da; Orsi, Paula Miranda Esteves; Espíndola, Rodolfo Pereira; Albanez, A.V.; Rosa, Bruno Barbosa; Carvalho, Maria Graças Souza; Garcia, José Antônio Dias

doi:10.1590/1414-431x20209303

Cited by 9 publications

(3 citation statements)

References 29 publications

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“…Recent animal and cell studies suggest that white tea may be particularly effective in ameliorating abnormal lipid metabolism. A tea cocktail containing white tea partially prevented hyperlipidemia, reduced serum high-density lipoprotein levels, insulin resistance, and increased C-reactive protein levels, while completely preventing left ventricular hypertrophy in mice fed with a high-fat diet (Ferreira et al, 2020). Another study found that WTE ameliorated obesity, lipid accumulation, hepatic steatosis, and liver injury in a mouse model of nonalcoholic fatty liver disease (Li et al, 2022).…”

Section: Metabolic Diseasesmentioning

confidence: 99%

White Tea: A Review on Composition Characteristics, Extraction Techniques, and Application Potentials

Guo,

Feng,

Jing

et al. 2024

jtsr

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White tea has gained significant popularity worldwide due to its health benefits. As the least processed type of tea, white tea is known for preserving a high level of bioactive phytochemicals from fresh tea leaves. However, the composition of white tea can vary widely depending on factors such as harvest season, processing methods, and storage conditions. To effectively utilize the bioactive compounds in white tea, the extraction process plays a crucial role, and researchers have been actively exploring optimal parameters and innovative techniques to improve extraction efficiency. Additionally, extensive research is being conducted to uncover the diverse functionalities of white tea, leading to new discoveries and insights into its applications in the food and therapeutic industries. This review provides an overview of the compositional profiles of different white teas, highlights advances in the optimization of white tea extraction, and provides up-to-date literature on the diverse functional properties of white tea.

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Section: Metabolic Diseasesmentioning

confidence: 99%

White Tea: A Review on Composition Characteristics, Extraction Techniques, and Application Potentials

Guo,

Feng,

Jing

et al. 2024

jtsr

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“…Ruthin, namely tea catechin, is very significant for human health. In the absence of it, the permeability of capillary blood vessels increases, and their strength decreases (Vinson, 2000;Sinija, Mishra, 2008;Sharangi, 2009;Ferreira et al, 2020). When acting together with vitamin C (with which it is often found in food), the latter is better absorbed and retained in the body and more successfully prevents scurvy (Skotnicka et al, 2011).…”

Section: Flavonoid Compounds With P-vitamin Activitymentioning

confidence: 99%

Biologically active substances of Camellia sinensis in a humid subtropical climate of Russia

Белоус

Platonova

2021

Potr. S. J. F. Sci.

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We did a comparative analysis of tea and raw tea materials. There is an increase in the content of carotenoids and flavonoids (thearubigins and theaflavins) in June, a decline in July, and August, and consequently a slight increase again in other months. The increase is due to unfavorable conditions – drought during these periods. In raw new variety forms No. 855 and No. 582, as well as in black tea variety form No. 582 (0.09 mg.g-1), we determined the high value of theaflavins (0.10; 0.11 and 0.09 mg.g-1, respectively). The highest content of thearubigins was found in variety forms No. 582 and No. 3823 (1.33 mg.g-1 and 1.17 mg.g-1). Ascorbic acid is significantly disintegrated (on average 96 – 97%) in the production of black tea. In green tea, ascorbic acid disintegrates to a lesser extent, leaving about 13% of its initial amount in the raw material. The dynamics of GPOD activity in a 3-leaf sprout are variety-specific. At the beginning of the growing season (May), the activity of the enzyme was low – in the range of 0.363 to 0.607 g-unit in sec. In June, there is a decrease in activity, which, however, is not significant (p <0.05) and is due to the biological characteristics of the tea culture. In green tea, the ruthine is on average 3 times more than in black tea (on average about 38.09 and 12.12 mg.100g-1, respectively). We have identified 11 amino acids; the highest percentage accounted for proline (from 30 to 70%), valine (17 – 30%), and serine (about 10%). We have identified 11 amino acids in Krasnodar tea, a large proportion of these amino acids has proline, valine, and serine. There was a variation in the content of biologically active substances depending on genotype characteristics. Studies have identified some controversial issues that require explanation and further study.

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“…The pharmacological activity of C. sinensis extracts has been proven to help treat common ailments like hypertension, diabetes, and obesity. It also possesses anticancer, anti-inflammatory, antioxidant, and cardiopulmonary-protective properties [ 7 , 8 ]. Recently, tea was reported to have beneficial role in the modulation of human gut microbes [ 9 ], also.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of tea (Camellia sinensis L.) phytochemicals as multi-disease modulators, a multidimensional in silico strategy with the combinations of network pharmacology, pharmacophore analysis, statistics and molecular docking

Nag

2022

Mol Divers

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Tea ( Camellia sinensis L.) is considered as to be one of the most consumed beverages globally and a reservoir of phytochemicals with immense health benefits. Despite numerous advantages, tea compounds lack a robust multi-disease target study. In this work, we presented a unique in silico approach consisting of molecular docking, multivariate statistics, pharmacophore analysis, and network pharmacology approaches. Eight tea phytochemicals were identified through literature mining, namely gallic acid, catechin, epigallocatechin gallate, epicatechin, epicatechin gallate (ECG), quercetin, kaempferol, and ellagic acid, based on their richness in tea leaves. Further, exploration of databases revealed 30 target proteins related to the pharmacological properties of tea compounds and multiple associated diseases. Molecular docking experiment with eight tea compounds and all 30 proteins revealed that except gallic acid all other seven phytochemicals had potential inhibitory activities against these targets. The docking experiment was validated by comparing the binding affinities (Kcal mol −1 ) of the compounds with known drug molecules for the respective proteins. Further, with the aid of the application of statistical tools (principal component analysis and clustering), we identified two major clusters of phytochemicals based on their chemical properties and docking scores (Kcal mol −1 ). Pharmacophore analysis of these clusters revealed the functional descriptors of phytochemicals, related to the ligand–protein docking interactions. Tripartite network was constructed based on the docking scores, and it consisted of seven tea phytochemicals (gallic acid was excluded) targeting five proteins and ten associated diseases. Epicatechin gallate (ECG)-hepatocyte growth factor receptor (PDB id 1FYR) complex was found to be highest in docking performance (10 kcal mol −1 ). Finally, molecular dynamic simulation showed that ECG-1FYR could make a stable complex in the near-native physiological condition. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s11030-022-10437-1.

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Effect of Camellia sinensis teas on left ventricular hypertrophy and insulin resistance in dyslipidemic mice

Cited by 9 publications

References 29 publications

White Tea: A Review on Composition Characteristics, Extraction Techniques, and Application Potentials

White Tea: A Review on Composition Characteristics, Extraction Techniques, and Application Potentials

Biologically active substances of Camellia sinensis in a humid subtropical climate of Russia

Evaluation of tea (Camellia sinensis L.) phytochemicals as multi-disease modulators, a multidimensional in silico strategy with the combinations of network pharmacology, pharmacophore analysis, statistics and molecular docking

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