Expression of CHPF modulates cell proliferation and invasion in lung cancer

Cao, Chengsong; Liu, Yong; Wang, Qun; Zhao, Jing; Shi, Ming; Zheng, Jian

doi:10.1590/1414-431x20209021

Cited by 11 publications

(13 citation statements)

References 25 publications

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“…In the next step, we found that the expression of CHPF was highly expressed in stage III + IV or metastasis tissues compared to stage I + II or non-metastasis tissues, respectively. Moreover, we assessed the correlation between CHPF expression and the survival time in patients with BRCA, and found that patients with high expression of CHPF exhibited a poorer overall survival, DFS, DSS and PFS, which is in agreement with a previous study reporting that elevated CHPF expression resulted in a worse overall survival in lung cancer patients [25]. All of these data suggest that elevated CHPF expression may be related to poor overall survival in BRCA patients.…”

Section: Discussionsupporting

confidence: 89%

Chondroitin polymerizing factor promotes breast carcinoma cell proliferation, invasion and migration and affects expression of epithelial‐mesenchymal transition‐related markers

et al. 2021

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Chondroitin polymerizing factor (CHPF) plays an important role in the development of certain malignant tumors. However, the role of CHPF in breast carcinoma (BRCA) and its underlying mechanism are still not fully elucidated. Expression profiles for CHPF in BRCA tissues were retrieved from The Cancer Genome Atlas database and used for prognostic analysis. Cell viability, invasion and migration were measured in vitro using MCF7 and MDA-MB-231 cell lines upon knockdown or over-expression of CHPF. Bioinformatic analysis showed that CHPF was substantially upregulated in BRCA tissues, and a quantitative reverse transcriptase-PCR was performed to confirm its upregulation in BRCA cells. High expression of CHPF was observed to be significantly associated with pathologic stage, metastasis and worse prognosis. We also observed that depletion of CHPF significantly inhibited cell proliferative, invasive and migratory abilities, whereas overexpression of CHPF exerted the opposite effects. Furthermore, analysis of the GEPIA database revealed that CHPF expression is positively correlated with the epithelial-mesenchymal transition-related markers vimentin, Snail, Slug and motion-related protein matrix metallopeptidase 2; these findings were confirmed via western blotting. Our data suggest that CHPF may contribute to BRCA progression by modulating epithelial-mesenchymal transition-related markers and matrix metallopeptidase 2 expression. Breast carcinoma (BRCA) is the most commonly diagnosed cancer in women and ranks the second among causes of cancer relative death in women [1]. Globally, the incidence rate of BRCA has been rising rapidly

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Section: Discussionsupporting

confidence: 89%

Chondroitin polymerizing factor promotes breast carcinoma cell proliferation, invasion and migration and affects expression of epithelial‐mesenchymal transition‐related markers

et al. 2021

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“…The mentioned signature could be considered as novel potential therapeutic targets. Reports reported that NUP37 promoted lung cancer cell proliferation and inhibited apoptosis [10], overexpressed TGFA, HPF induce cell proliferation and invasion in lung cancer [11,12] Downregulated ALDH7A1 increased hepatocellular and renal clear carcinomas cell migration and invasiveness [13]. FBP2 over expression inhibits sarcoma cell growth [14].…”

Section: Discussionmentioning

confidence: 99%

Identification and Validation of a Glycolysis Related Metabolic Reprogramming Gene Signature for Predicting Survival in Colon Cancer Patients

Liu¹,

Wu²,

Chen³

2021

Preprint

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Background Colon cancer (CC) is one of the most common gastrointestinal malignant tumors with high mortality rate. Because of malignancy and easily metastasis feather, and limited treatments, the prognosis of CC remains poor. Glycolysis is a metabolic process of glucose in anoxic environments which is an important way to provide energy for tumor. The role of glycolysis in CC largely remains unknown and is necessary to be explored. Method In our study, we analyzed glycolysis related genes expression in CC, patients gene expression and corresponding clinical data were downloaded from GEO dataset, glycolysis related genes sets were collected from Msigdb. Through COX regression analysis, prognosis model based on glycolysis-related genes was established. The efficacy of gene model was tested by Survival analysis, ROC analysis and PCA analysis. Furthermore, the relationship between risk scores and clinical characteristic was researched. Results Our findings identified 13 glycolysis related genes (NUP107, SEC13, ALDH7A1, ALG1, CHPF, FAM162A, FBP2, GALK1, IDH1, TGFA, VLDLR, XYLT2 and OGDHL) consisted prognostic prediction model with relative high accuracy. The relationship between prediction model and clinical feathers were specifically studied, results showed age > 65years, TNM III-IV, T3-4, N1-3, M1 and high-risk score were independent prognostic risk factors with poorer prognosis. Finally, model genes were significantly expressed and EMT were activated in CC patients. Conclusion This study provided a new aspect to advance our understanding in the potential mechanism of glycolysis in CC.

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“…In fact, the placenta contained ~10-fold more CS than any other tissue, and this CS was of significantly higher MW. Interestingly, recent studies have reported high expression of the CS polymerizing factor CHPF in cancers, such as adenocarcinomas of the lung (37,38), melanoma (39), and gliomas (40), and that CHPF knockdown inhibits proliferation and migration. Here, we found that several CS biosynthesis enzymes, including CHPF and CHPF2, were upregulated in a diverse set of cancer types.…”

Section: Discussionmentioning

confidence: 99%

The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility

Spliid

Toledo

Sanderson

et al. 2021

Journal of Biological Chemistry

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Expression of CHPF modulates cell proliferation and invasion in lung cancer

Cited by 11 publications

References 25 publications

Chondroitin polymerizing factor promotes breast carcinoma cell proliferation, invasion and migration and affects expression of epithelial‐mesenchymal transition‐related markers

Chondroitin polymerizing factor promotes breast carcinoma cell proliferation, invasion and migration and affects expression of epithelial‐mesenchymal transition‐related markers

Identification and Validation of a Glycolysis Related Metabolic Reprogramming Gene Signature for Predicting Survival in Colon Cancer Patients

The specificity of the malarial VAR2CSA protein for chondroitin sulfate depends on 4-O-sulfation and ligand accessibility

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