Association between matrix metalloproteinase-1 (MMP-1) protein level and the risk of rheumatoid arthritis and osteoarthritis: a meta-analysis

Abstract

Recent publications have investigated the potential role of the protein level of matrix metalloproteinase-1 (MMP-1) in the susceptibility to rheumatoid arthritis (RA) and osteoarthritis (OA). However, no unanimous conclusion was obtained. Therefore, we carried out a meta-analysis to explore the association between MMP-1 expression and these two clinical disorders. After database searching and screening, we enrolled a total of eighteen articles for the pooled analysis. We observed a significant association between RA cases and controls in the whole population [SMD (standard mean difference)=1.01, P=0.017]. There were similar positive results in the subgroup analysis of “population-based control” (SMD=1.50, P=0.032) and “synovial fluid” (SMD=1.32, P=0.049). In addition, we observed an increased risk in OA cases, compared with controls, in the overall analysis (SMD=0.47, P=0.004) and subsequent subgroup analysis of “knee OA” (SMD=0.86, P<0.001), “Asian/China” (SMD=0.76, P=0.003), “cartilage-Asian/China” (SMD=1.21, P<0.001), and “synovial fluid-Asian/China” (SMD=0.73, P=0.004). In summary, a high protein level of MMP-1 in synovial fluid may be associated with the susceptibility to RA, and the high MMP-1 level in the cartilage tissue or synovial fluid may be related to the pathogenesis of knee OA in the Chinese population. This should be confirmed by larger sample sizes.

Exploring the Early Molecular Pathogenesis of Osteoarthritis Using Differential Network Analysis of Human Synovial Fluid

“…In the late-stage OA group, we found differentially expressed proteins of matrix metalloproteinases (MMPs) such as: MMP1 (log2 fold change 4.31, 95% CI [3.85, 4.76]), collagenase 3 (2.21 [1.76, 2.67]) and stromelysin-1 (1.89, [1.43, 2.35]). These proteins degrade ECM components and are well-studied as OA biomarkers ( 32 , 33 , 34 , 35 , 36 ). Furthermore, among the proteins with highest absolute log2 fold change we found upregulation of inhibin beta A chain (3.58, [3.04, 4.11]), tumor necrosis factor-inducible gene 6 protein (2.60, [2.09, 3.12]) and kininogen-1 (2.60, [2.13, 3.07]) as well as downregulation of NAD(P)H dehydrogenase (quinone) 1 (−3.29, [−3.79, −2.79]), hemoglobin subunit alpha (−3.25, [−3.79, −2.71]) and aldehyde dehydrogenase, mitochondrial (−2.87, [−3.37, −2.37]) ( Supplemental Data S2 ).…”

A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m

“…Matrix metalloproteinases (MMPs) are zinc-containing, calcium-dependent endo-peptidases that are involved in degrading all kinds of ECM proteins, as well as in multiple cellular processes, such as cellular adhesion, differentiation, migration, proliferation, angiogenesis, host defense, and apoptosis [ 167 , 168 , 169 , 170 , 171 , 172 ]. MMPs are produced by macrophages, endothelial cells, leukocytes, synoviocytes, and chondrocytes and are essential for developmental and repair processes.…”

Genetic and Epigenetic Aspects of Skin Collagen Fiber Turnover and Functioning

“…Furthermore, certain collagens, such as collagen type III, are more sensitive to hydrolysis by various proteases, since they have more flexible potential cleavage sites. Stromyelysins are capable of cleaving fibronectin, laminin, collagens type IV and VII, cell surface proteins, and other molecules that affect cell differentiation and proliferation [93].…”