Genetic and Epigenetic Aspects of Skin Collagen Fiber Turnover and Functioning

Потекаев, Н. Н.; Borzykh, Olga B.; Medvedev, German V.; Петрова, М. М.; Gavrilyuk, Oksana A.; Karpova, Elena I.; Trefilova, Vera V.; Demina, O.M.; Попова, Т. Е.; Shnayder, Natalia A.

doi:10.3390/cosmetics8040092

Cited by 9 publications

(4 citation statements)

References 108 publications

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“…The results that genes expressed in the epidermal basal layer and dermis were significantly upregulated in the SNF dermal/epidermal model compared with the Collagen dermal/epidermal model suggested that while fibroblasts in the Collagen dermal/epidermal model were covered by collagen, fibroblasts in rigid SNF were highly proliferative. hCOL1, hCOL3, and hCOL4 are associated with skin elasticity [20,[48][49][50]. Therefore, upregulated expression of hCOL1, hCOL3, and hCOL4 in SNF dermal/epidermal model means that it has high functions as a dermal/epidermal skin model.…”

Section: Discussionmentioning

confidence: 99%

Fabricating a Novel Three-Dimensional Skin Model Using Silica Nonwoven Fabrics (SNF)

Iijima

2022

Applied Sciences

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Silica nonwoven fabrics (SNF) prepared using electrospinning have high biocompatibility, thermal stability, and porosity that allows growing three-dimensional culture of cells. In this study, we used SNF to construct a three-dimensional artificial skin model consisting of epidermal and dermal layers with immortalized and primary human cell lines, creating a novel model that minimizes tissue shrinkage. As a result, SNF dermal/epidermal models have enhanced functions in the basement membrane, whereas Collagen dermal/epidermal models have advantages in keratinization and barrier functions. The SNF dermal/epidermal model with mechanical strength formed a basement membrane mimicking structure, suggesting the construction of a stable skin model. Next, we constructed three-dimensional skin models consisting of SNF and collagen. In the combination models, the expression of genes in the basement membrane was significantly increased compared with that in the Collagen dermal/epidermal model, and the gene for keratinization was increased compared with that in the SNF dermal/epidermal model. We believe that the combination model can be a biomimetic model that takes advantage of both SNF and collagen and can be applied to various basic research. Our new skin model is expected to be an alternative method for skin testing to improve the shrinkage of the collagen matrix gel.

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Section: Discussionmentioning

confidence: 99%

Fabricating a Novel Three-Dimensional Skin Model Using Silica Nonwoven Fabrics (SNF)

Iijima

2022

Applied Sciences

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“…Decreased collagen numbers induce myofibroblast apoptosis as a result of these cytokine activities (Potekaev et al, 2021). When the researchers compared scar fibroblasts with their normal counterparts, they found that collagenase mRNA was reduced and their ability to digest soluble collagen was also reduced (Zhu et al, 2013).…”

Section: Volume 35 Issue 2 (2024)mentioning

confidence: 99%

Advances in Quantitative and Qualitative Assessment of Collagen in Cutaneous Wound Healing

Santoso,

Widyantara,

Kencana

et al. 2024

Indonesian J Pharm

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Wound healing treatment is a challenging strategy in skin drug delivery due to its complexities. During wound healing stages, fibroblast deposit extracellular matrix components, which majority is collagen. Fibrillar collagen, particularly collagen I, is the predominant skin collagen during the healing process. Collagen analysis is a crucial process in wound healing study since it indicates impairment process of collagen production such as scar formation which is aesthetically unwanted. Therefore, recent studies developed quantitative and qualitative evaluation of collagen fiber based on histological staining. Thus, a comprehensive discussion of those studies to provide an insight for pharmacists, dermatologists, and skin researchers to designate a precise assessment in wound healing process. Keywords: skin, wound, collagen, assessment

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“…This natural polymer, representing 25% of the dry weight of all the body tissues including skin, is synthesized under the influence of diet, environment and age. However, its synthesis depends also on the state of hormonal background, the inherent genetic sequences and the epigenetic regulation of the gene's activity, which encode key proteins and enzymes during the collagen formation [80,81]. To this end, it is important to remember the many essential roles played by the previously reported ECM which, produced principally from fibroblasts, provides structural support for cells and tissues, modulating cell morphology, proliferation, migration and also gene expression [82,83].…”

Section: Collagenmentioning

confidence: 99%

Active Ingredients and Carriers in Nutritional Eco-Cosmetics

Morganti

Lohani

Gagliardini³

et al. 2023

Compounds

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Beauty and personal care became a significant part of the global economy for two reasons: (1) The elderly growing in the global population and (2) the desire of women and men to appear younger and more attractive. Thus, both young and old people are looking for revolutionary nutritional eco-cosmetics (combined use of cosmeceuticals and nutraceuticals) manufactured by natural active ingredients, using biopolymers as substrates, and made by innovative and sustainable technologies. Consequently, the market of both cosmetics and diet supplements is continually growing together with the request of natural active ingredients, including bio-peptides and biological macromolecules such as chitin and lignin. Therefore, both consumers and industry need to recover innovative active ingredients and carriers (vehicles), naturally derived and supported by advanced methods for controlling their effectiveness and safeness on skin and mucous membrane layers. The use of selected bio-ingredients, such as hyaluronic acid and bio-mimetic peptides, obtained by advanced, innovative and sustainable bio nanotechnologies, will be of interest to develop smart cosmeceutical and nutraceutical formulations. Innovation is considered the key business strategy to drive sustainable economic growth. For trying to reduce waste and produce sustainable, biodegradable and innovative products, the realization of new non-woven tissues, used as carriers for making innovative cosmeceuticals and nutraceuticals was considered. Both carriers and active ingredients have been obtained from food waste to reduce loss and pollution. This review will report a brief description of the skin functions, trying also to focus and discuss some of the active ingredients and carriers used in nutritional eco-cosmetics to clarify the supposed mechanism of action, effectiveness and safeness of both active ingredients and carriers, as well as the supposed activity of beauty and personal care products.

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Genetic and Epigenetic Aspects of Skin Collagen Fiber Turnover and Functioning

Cited by 9 publications

References 108 publications

Fabricating a Novel Three-Dimensional Skin Model Using Silica Nonwoven Fabrics (SNF)

Fabricating a Novel Three-Dimensional Skin Model Using Silica Nonwoven Fabrics (SNF)

Advances in Quantitative and Qualitative Assessment of Collagen in Cutaneous Wound Healing

Active Ingredients and Carriers in Nutritional Eco-Cosmetics

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