Association between MCP-1 -2518A>G polymorphism and asthma susceptibility: a meta-analysis

Abstract

The published data on the association between MCP-1 -2518A>G polymorphism and asthma susceptibility are inconclusive. Therefore, we performed a meta-analysis to estimate the impact of MCP-1 -2518A>G polymorphism on asthma susceptibility. PubMed, Web of Science, Wanfang, and China National Knowledge Infrastructure (CNKI) databases were used to identify eligible studies. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to calculate the strength of association. Sensitivity analysis was performed to evaluate the influence of individual studies on the estimates of overall effect, and funnel plots and Egger's test were used to assess publication bias. Eight publications with 1562 asthma patients and 1574 controls were finally identified. Overall, we found no significant association between MCP-1 -2518A>G polymorphism and asthma susceptibility in any of the genetic model comparisons. After stratified analysis by ethnicity, the results showed that a significant association with asthma risk was found in Caucasians in all the genetic models. However, a protective association was found in Africans under the dominant model. The present meta-analysis suggested that the MCP-1 -2518 A>G polymorphism is a risk factor for asthma in the Caucasian population, nevertheless it has a protective effect in the African population.

MCP-1-2518 A>G and CCR2-V64I Polymorphism in Pediatric Asthma: A Single Egyptian Center Study

“…Being an African country, our contradicting results may be explained by a study done in 2014 which discussed gene -gene interactions among MCP genes polymorphisms in asthma, which suggested that there was no single polymorphism of MCP-1 or MCP-2 gene that was associated with asthma but rather a nonindependence of effect or a gene -gene interaction is often described as "epistasis" (20), that concept was not investigated in the current study which was conclusively investigating a single polymorphism regardless its interaction with possible other existing polymorphisms. Furthermore, we can consider asthma genetic heterogeneity with respect to regulation of MCP-1 expression to explain our result (21).…”

“…The analysis was stratified by ethnicity. Caucasian population showed an increased risk of asthma with MCP-1 -2518 A>G polymorphism, African population showed a protective effect and no significant association was found in the Asian population (20).…”

MCP-1-2518 (A>G) polymorphism and asthma risk: a pilot case-control study in Cameroon

“…This suggested that not only the susceptibility to asthma, but also its severity could be determined by this gene in Cameroonians. However, some authors have rather found MCP-1 genes as a protective factor in Africans as opposed to Caucasians, however, few studies have been conducted to date to verify this assertion [ 20 ]. However, there is always a complexity of interaction between single-nucleotide polymorphisms (SNPs) that can vary within populations, hence the importance of increasing the number of studies in order to get a clearer picture [ 21 ].…”

Study on the association between the polymorphism of MCP-1 rs1024611 and the genetic susceptibility of type 2 diabetes with sepsis

“…MCP-1 plays a key role in regulating monocyte chemotaxis and endothelial activation, as well as regulating the progression of inflammation and the production of proinflammatory cytokines. [ 23 ] Lee et al [ 24 ] have reported that the MCP-1 rs1024611 polymorphism is associated with Alzheimer disease, [ 24 ] asthma, [ 25 ] immunoglobulin A nephropathy, [ 26 ] lupus nephritis, [ 27 ] diabetic nephropathy, [ 28 ] and diabetic foot ulcer. Inhibition of MCP-1 or specific MCP-1 antagonist can inhibit the release of TNF-α, IL-1β, and IL-6 from macrophages.…”