A study on changes of the resting-state brain function network in patients with amnestic mild cognitive impairment

Abstract

This study aimed to explore the structural and functional characteristics of the neural network of resting-state brain activities in patients with amnestic mild cognitive impairment (aMCI) by functional magnetic resonance imaging (fMRI) technology. Resting state fMRI scanning was performed on 10 clinically diagnosed aMCI patients and 10 healthy volunteers, and the difference in the resting-state brain activities between aMCI patients and healthy volunteers was compared using the brain function network regional homogeneity (ReHo) analysis method. Results of the ReHo analysis of aMCI patients and healthy volunteers revealed that the ReHo value significantly increased in the posterior cingulate gyrus region, medial frontal lobe, medial cortex of the prefrontal lobe, and part of the parietal lobe. Compared with the normal elderlies, ReHo decreased in aMCI patients in the left temporal lobe (middle temporal gyrus and inferior temporal gyrus), left parahippocampal gyrus, occipital lobe, lingual gyrus, precuneus, and other regions while ReHo increased in regions of the right frontal lobe (inferior frontal gyrus), left superior temporal gyrus, precentral gyrus (frontal lobe), right thalamus, left fusiform gyrus, and other regions. In the resting state, there may be regional abnormalities in brain functional areas in aMCI patients, which may be associated with cognitive impairment.

An Activation Likelihood Estimation Meta-Analysis of Specific Functional Alterations in Dorsal Attention Network in Mild Cognitive Impairment

“…SPL has been also related to properties that deal with visuospatial and spatial motion ( Banaszkiewicz et al, 2021 ). An rs-fMRI study also showed increased ReHo in part parietal lobes in MCI, consistent with our findings ( Min et al, 2019 ). Thus, we may hypothesize that the elevation of increased ReHo value in the SPL also plays an essential role in the transition process of AD.…”

Identifying resting state differences salient for resilience to chronic pain based on machine learning multivariate pattern analysis

“…Unfortunately, related past CP-specific studies are lacking. Nonetheless, our results and other clinically-based research linking increased Rs activity in these regions with cognitive impairment, bipolar disorder, and reduced vigor (Kunisato et al, 2011;Min et al, 2019;Qiu et al, 2019) provide preliminary evidence for the hypothesis that these structures are involved in resilience albeit effects may not be specific to CP.…”

Altered Regional Cerebral Blood Flow and Brain Function Across the Alzheimer's Disease Spectrum: A Potential Biomarker

“…The study identified multiple areas of the brain with decreased activity and disrupted FC (Liu et al, 2008 ; Han et al, 2012 ; Zhang et al, 2012 ; Pan et al, 2017 ; Min et al, 2019 ). Additionally, two recent meta-analyses demonstrated that the decreased ALFF and ReHo in patients with MCI were primarily located in the BPCC/PCUN, bilateral frontal, left occipitotemporal cortex, and parietal lobule compared to HC (Pan et al, 2017 ; Zhen et al, 2018 ).…”