An Activation Likelihood Estimation Meta-Analysis of Specific Functional Alterations in Dorsal Attention Network in Mild Cognitive Impairment

Song, Yu; Chen, Shanshan; Ge, Honglin; Zheng, Yan; Qi, Wenzhang; Yuan, Qianqian; Liang, Xuhong; Lin, Xingjian; Chen, Jiu

doi:10.3389/fnins.2022.876568

Cited by 11 publications

(11 citation statements)

References 77 publications

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“…According to the previous meta‐analysis, the brain areas of DAN were summarized. 15 Then, we used the WFU_PickAtlas toolbox ( www.ansir.wfubmc.edu ) in the matlab2013b to make the DAN mask. The DAN mask included bilateral precentral gyrus (PreCG), superior frontal gyrus (SFG), middle frontal gyrus (MFG), superior parietal lobule (SPL), intraparietal sulcus (IPS), inferior occipital gyrus (IOG), inferior temporal gyrus (ITG), and MTG.…”

Section: Methodsmentioning

confidence: 99%

“…The fractional amplitudes of low‐frequency fluctuation (fALFF), regional homogeneity (ReHo), and functional connectivity (FC) are the three indicators measured by the rs‐fMRI. 15 They, respectively, indicate the spontaneous activity of neurons, 16 the consistency of neuronal activity, 17 and neurophysiological activities in two or more spatially corresponding regions. 18 Furthermore, structural magnetic resonance imaging (MRI) is also sensitive to examine structural brain alterations, including gray matter volume (GMV) and cortical thickness.…”

Section: Introductionmentioning

confidence: 99%

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Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease

et al. 2023

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Objectives Subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) are known as the preclinical and early stage of Alzheimer's disease (AD). The dorsal attention network (DAN) is mainly responsible for the “top‐down” attention process. However, previous studies mainly focused on single functional modality and limited structure. This study aimed to investigate the multimodal alterations of DAN in SCD and aMCI to assess their diagnostic value in preclinical and early‐stage AD. Methods Resting‐state functional magnetic resonance imaging (MRI) was carried out to measure the fractional amplitude of low‐frequency fluctuation (fALFF), regional homogeneity (ReHo), and functional connectivity (FC). Structural MRI was used to calculate the gray matter volume (GMV) and cortical thickness. Moreover, receiver‐operating characteristic (ROC) analysis was used to distinguish these alterations in SCD and aMCI. Results The SCD and aMCI groups showed both decreased ReHo in the right middle temporal gyrus (MTG) and decreased GMV compared to healthy controls (HCs). Especially in the SCD group, there were increased fALFF and increased ReHo in the left inferior occipital gyrus (IOG), decreased fALFF and increased FC in the left inferior parietal lobule (IPL), and reduced cortical thickness in the right inferior temporal gyrus (ITG). Furthermore, functional and structural alterations in the SCD and aMCI groups were closely related to episodic memory (EM), executive function (EF), and information processing speed (IPS). The combination of multiple indicators of DAN had a high accuracy in differentiating clinical stages. Conclusions Our current study demonstrated functional and structural alterations of DAN in SCD and aMCI, especially in the MTG, IPL, and SPL. Furthermore, cognitive performance was closely related to these significant alterations. Our study further suggested that the combined multiple indicators of DAN could be acted as the latent neuroimaging markers of preclinical and early‐stage AD for their high diagnostic value.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease

et al. 2023

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“…The attention network was associated with working memory and episodic memory encoding. Recent studies have found intra-network and inter-network functional disruptions in the DAN in MCI patients [39,40]. Mind-body exercise significantly increased the selective attention of MCI patients, and meanwhile decreased functional connectivity in attention network [41].…”

Section: Discussionmentioning

confidence: 98%

The Switching Rates of Dynamic Functional Networks Differently Contribute to Cross-Sectional and Longitudinal Cognition in Mild Cognitive Impairment

Hu¹,

Deng²,

Li³

2022

J. Integr. Neurosci.

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Background:The relationship between switching rate of multilayer functional network and cognitive ability in mild cognitive impairment (MCI) and Alzheimers' disease remains unclear. Methods: We followed up MCI patients for one year and analyzed the association of switching rates with cognitive decline. The iterative and ordinal Louvain algorithm tracked the switching of functional networks, while elastic network regression and Bayesian belief networks were used to test the relationship between network switching rate and cognitive performance cross-sectionally and longitudinally. Results: The switching rate of the default mode network positively correlated with better cognitive function, while that of salience and executive control network was negatively associated with memory and executive function. The lower default mode network (DMN) switching rate predicted MCI progression to dementia, while the lower sensorimotor network switching rate heralded in slower cognitive decline. Conclusions: The present study investigated the predictive effect of switching rate on cognitive performance, as well as MCI progression to dementia. The inverse effect from different functional networks may become useful for early diagnosis and revealing the mechanism of neural networks in cognitive decline.

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“…One paper looking at structural MRI found cortical thinning in APOE ε4 carriers in the frontoparietal regions that form DAN functional nodes ( Wolk and Dickerson, 2010 ). Most studies on the DAN and its relation to AD are from clinical populations with either mild cognitive impairment or dementia, demonstrating that “top-down” attention processing mediated by the DAN is impaired by mild cognitive impairment and AD with decreased RSFC observed in both populations ( Li et al, 2012 ; Qian et al, 2015 ; Zhang et al, 2015 ; Mcdonough et al, 2019 ; Wu et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Differences in resting state functional connectivity underlie visuomotor performance declines in older adults with a genetic risk (APOE ε4) for Alzheimer’s disease

Rogojin

Gorbet

Hawkins

et al. 2022

Front. Aging Neurosci.

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IntroductionNon-standard visuomotor integration requires the interaction of large networks in the brain. Previous findings have shown that non-standard visuomotor performance is impaired in individuals with specific dementia risk factors (family history of dementia and presence of the APOE ε4 allele) in advance of any cognitive impairments. These findings suggest that visuomotor impairments are associated with early dementia-related brain changes. The current study examined the underlying resting state functional connectivity (RSFC) associated with impaired non-standard visuomotor performance, as well as the impacts of dementia family history, sex, and APOE status.MethodsCognitively healthy older adults (n = 48) were tested on four visuomotor tasks where reach and gaze were increasingly spatially dissociated. Participants who had a family history of dementia or the APOE ε4 allele were considered to be at an increased risk for AD. To quantify RSFC within networks of interest, an EPI sequence sensitive to BOLD contrast was collected. The networks of interest were the default mode network (DMN), somatomotor network (SMN), dorsal attention network (DAN), ventral attention network (VAN), and frontoparietal control network (FPN).ResultsIndividuals with the ε4 allele showed abnormalities in RSFC between posterior DMN nodes that predicted poorer non-standard visuomotor performance. Specifically, multiple linear regression analyses revealed lower RSFC between the precuneus/posterior cingulate cortex and the left inferior parietal lobule as well as the left parahippocampal cortex. Presence of the APOE ε4 allele also modified the relationship between mean DAN RSFC and visuomotor control, where lower mean RSFC in the DAN predicted worse non-standard visuomotor performance only in APOE ε4 carriers. There were otherwise no effects of family history, APOE ε4 status, or sex on the relationship between RSFC and visuomotor performance for any of the other resting networks.ConclusionThe preliminary findings provide insight into the impact of APOE ε4-related genetic risk on neural networks underlying complex visuomotor transformations, and demonstrate that the non-standard visuomotor task paradigm discussed in this study may be used as a non-invasive, easily accessible assessment tool for dementia risk.

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An Activation Likelihood Estimation Meta-Analysis of Specific Functional Alterations in Dorsal Attention Network in Mild Cognitive Impairment

Cited by 11 publications

References 77 publications

Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease

Functional and structural alterations of dorsal attention network in preclinical and early‐stage Alzheimer's disease

The Switching Rates of Dynamic Functional Networks Differently Contribute to Cross-Sectional and Longitudinal Cognition in Mild Cognitive Impairment

Differences in resting state functional connectivity underlie visuomotor performance declines in older adults with a genetic risk (APOE ε4) for Alzheimer’s disease

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