Quality of life on hemodialysis and inflammation: a descriptive analysis

Bacci, Marcelo Rodrigues; Adami, Fernando; Figueiredo, Francisco Winter dos Santos; Alves, Beatriz da Costa Aguiar; Veiga, Gláucia Luciano da; Fonseca, F.L.A.

doi:10.1590/1414-431x20187355

Cited by 8 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our study was similar to study conducted by Bacci et al in Brazil, recruited 31 regular HD patients, obtained that IL-6 was significantly negative correlated with activity limitation one aspect of QoL. 17 Bossola et al in Rome Italy examined 100 regular HD patients that obtained that fatigue, was significantly correlated with IL-6. 12 This is due to the effect of IL-6 in inflammation which affects to anorexia, depression, fatigue, PEW, and then decrease the aspects of the QoL of regular HD patients.…”

Section: Disclosures Conflict Of Interestsupporting

confidence: 91%

Role of malnutrition inflammation score and interleukin-6 on quality of life of regular hemodialysis patients

2022

View full text Add to dashboard Cite

Background: Malnutrition, systemic inflammation, and atherosclerosis known as MIA syndrome occurs in patients who have undergone regular hemodialysis (HD) and can lower their quality of life (QoL). Current study aimed to determine the interrelation of malnutrition and inflammation to QoL. Methods: A cross-sectional analytic study was conducted in our hemodialysis installation. We performed Malnutrition Inflammation Score (MIS) and measure serum IL-6 to determine malnutrition and inflammation conditions in regular HD patients and utilized ‘Kidney Disease Quality of Life-Short Form (KDQOL-SF) to assess QoL MIS. IL-6 cut-off point were determined by the Receiver Operating Curves (ROC) then we performed linear regression to analyze the relationship level of MIS and IL-6 with level of QoL. We also used path analysis to prove the mechanism model of MIS and IL-6 to QoL on regular HD patients. Results: This study consisted of 60 regular HD patients, 40 (66.7%) of men with mean age of 51.8 years and 78 months average of dialysis vintage. Good QoL was obtained ≥60 overall health (above the median value) and high level of MIS was obtained ≥5 with 75% sensitivity and 21.8% specificity, while high IL-6 level were ≥47.21 pg/mL, with 62.2% sensitivity and specificity of 78.3%. This study found the prevalence of protein-energy wasting (PEW) in regular HD patients was 81.7% by using high level of MIS. MIS were significantly correlated to IL-6 (r = 0.376, p = 0.003) however high level of MIS were uncorrelated to poor QoL. The mechanism of the interrelation of MIS, IL-6, and QoL showed on path analysis that MIS was 15% directly correlated to QoL, however, IL-6 indirectly correlated to QoL on regular hemodialysis patients. Conclusion: MIS and IL-6 were correlated to QoL and MIS also correlated to IL-6. Malnutrition inflammatory score directly affected QoL but IL-6 indirectly affected QoL in regular HD patients.

show abstract

Section: Disclosures Conflict Of Interestsupporting

confidence: 91%

Role of malnutrition inflammation score and interleukin-6 on quality of life of regular hemodialysis patients

2022

View full text Add to dashboard Cite

show abstract

“…Higher scores indicate better HRQoL. Cronbach’s alpha for PCS-12 and MCS-12 in the general Korean population was 0.83 and 0.79 [ 27 ] and in our study was 0.84 and 0.82, respectively.…”

Section: Methodssupporting

confidence: 53%

Symptom Profiles, Health-Related Quality of Life, and Clinical Blood Markers among Korean Community-Dwelling Older Adults Living with Chronic Conditions

Park

Lukkahatai

Perrin

et al. 2021

IJERPH

View full text Add to dashboard Cite

Older adults suffer from multiple symptoms, which negatively affects their health-related quality of life. The single-symptom management approach has been less than effective. The data of 2362 Korean community-dwelling older adults aged 70 and above were analyzed in the Korean Frailty and Aging Cohort Study (KFACS) study. A cluster analysis, correlation analysis, and logistic regression were used to analyze the data. We found three symptom clusters: high symptom burden (HSB, n = 1032); pain and fatigue group (PAF, n = 566); and the sleep deprivation group (SDP, n = 764). Participants in the HSB group are more likely to be of old age (OR = 1.1), be female (OR = 2.4), live in a rural area (OR = 1.4), have low physical activity (OR = 0.9), and have multiple chronic conditions (OR = 1.5). The clinical blood markers analysis showed a negative relationship among the physical health, free T4 (r = −0.083, p < 0.01) and insulin (r = −0.084, p < 0.01). The sex-specific blood markers analysis showed differences among three clusters. While free testosterone (male: r = 0.124, female: r = 0.110, p < 0.05) and dehydroepiandrosterone (DHEA) (male: r = 0.352 and female: r = 0.134, p < 0.05) were associated with physical health in the HSB group, only free testosterone was associated with mental health (male: r = −0.093, and female: r = −0.116, p < 0.05) in the SDP group. These findings suggest the potential role of the patient’s sex and sex hormones in symptoms of Korean community-dwelling older adults. Understanding the symptom profiles and impact of biopsychosocial factors may enhance precision symptom management.

show abstract

“…In the study of MR Bacci et al (2018), it was found that there was a negative correlation between the increase in pro-inflammatory cytokines IL6, CRP, TNF-, and Ferritin and the KDQOL score SF-36. On the physical health subscale, there is a moderate correlation.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the Indonesian Renal Registry (IRR) report, in 2018, there were 147.340 kidney failure patients undergoing hemodialysis therapy. 4 In patients with chronic kidney disease (CKD) undergoing hemodialysis, there is an increase in proinflammatory cytokines, including IL6, CRP, TNF-α, and Ferritin (Bacci, 2018).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Giving Garlic Extract (Allium Sativum) on the Scoring of KDQOL-SF 36 Sub-Scale of Physical and Mental Health in Patients Treating Chronic Hemodialysis at Mohammad Hoesin General Hospital, Palembang

Wahyudi

Rachman²,

Ali³

et al. 2022

jmhs

View full text Add to dashboard Cite

Chronic kidney disease (CKD) patients undergoing hemodialysis have an increase in proinflammatory cytokines. The quality of life of chronic kidney disease patients undergoing hemodialysis is affected by inflammation. Assessment of quality of life in CKD is done using the Kidney Disease Quality of Life Short Form Survey 36 questionnaire (KDQOL SF-36). Garlic (Allium sativum) has anti-inflammatory components. This study was conducted to determine the effect of giving garlic extract on the KDQOL score of the physical and mental health subscale at Mohammad Hoesin General Hospital, Palembang. The study was conducted in the Hemodialysis Room of Moh Hoesin General Hospital, Palembang. Department of Internal Medicine, RSUP Dr.. Moh Hoesin Palembang met the inclusion criteria consecutively in January 2022. Statistical analysis was carried out using the SPSS version 25.0 program. A total of 40 subjects participated in the study, 60% of whom were male. The mean age in the garlic extract group was 45.5 (28-58), and in the placebo group, 55 (26-59). Characteristics of the KDQOL value of the SF-36 physical health subscale with a value of 45.75 ± 22.08 in the garlic group with a significant increase (p = 0.041), the KDQOL value of the SF-36 mental health subscale with a value of 63.26 ± 20.56 in the group garlic with a significant increase (p=0.001). Garlic extract was shown to reduce the inflammatory process, followed by an increase in the KDQOL SF-36 score on the physical and mental health subscale.

show abstract

Quality of life on hemodialysis and inflammation: a descriptive analysis

Cited by 8 publications

References 29 publications

Role of malnutrition inflammation score and interleukin-6 on quality of life of regular hemodialysis patients

Role of malnutrition inflammation score and interleukin-6 on quality of life of regular hemodialysis patients

Symptom Profiles, Health-Related Quality of Life, and Clinical Blood Markers among Korean Community-Dwelling Older Adults Living with Chronic Conditions

The Effect of Giving Garlic Extract (Allium Sativum) on the Scoring of KDQOL-SF 36 Sub-Scale of Physical and Mental Health in Patients Treating Chronic Hemodialysis at Mohammad Hoesin General Hospital, Palembang

Contact Info

Product

Resources

About