Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells

Xiao, Yizhi; Diao, Qingchun; Liang, Yanhua; Zeng, Kang

doi:10.1590/1414-431x20176390

Cited by 9 publications

(5 citation statements)

References 10 publications

(12 reference statements)

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“…Xiao et al [129] have reported Co (II) complexes with the two flexible Schiff base ligands of type Py 3 CoL 1 (113) and Py 3 CoL 2 (114) (where, Py ¼ Pyridine, L 1 ¼ 3,5-ClC 6 130e134]. Gambino et al [130] have reported the bioactive gallium complexes with tridentate substituted salicylaldehyde semicarbazone of the type [Ga III (LeH) 2 ](NO 3 ) (115e119) (Scheme 26) and have investigated for their antitumor activity.…”

Section: Antitumor Activitymentioning

confidence: 99%

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Metal complexes driven from Schiff bases and semicarbazones for biomedical and allied applications: a review

Joshi

Mishra

et al. 2019

Materials Today Chemistry

217

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a b s t r a c tSchiff bases are versatile organic compounds which are widely used and synthesized by condensation reaction of different amino compound with aldehydes or ketones known as imine. Schiff base ligands are considered as privileged ligands as they are simply synthesized by condensation. They show broad range of application in medicine, pharmacy, coordination chemistry, biological activities, industries, food packages, dyes, and polymer and also used as an O 2 detector. Semicarbazone is an imine derivative which is derived from condensation of semicarbazide and suitable aldehyde and ketone. Imine ligand econtaining transition metal complexes such as copper, zinc, and cadmium have shown to be excellent precursors for synthesis of metal or metal chalcogenide nanoparticles. In recent years, the researchers have attracted enormous attention toward Schiff bases, semicarbazones, thiosemicarbazones, and their metal complexes owing to numerous applications in pharmacology such as antiviral, antifungal, antimicrobial, antimalarial, antituberculosis, anticancer, anti-HIV, catalytic application in oxidation of organic compounds, and nanotechnology. In this review, we summarize the synthesis, structural, biological, and catalytic application of Schiff bases as well as their metal complexes.

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Section: Antitumor Activitymentioning

confidence: 99%

“…Structure of 2,6-diacetylpyridine bis-4-phenyl-3-thiosemicarbazone(129). Structure of 2,6-diacetylpyridine bis-4-phenyl-3-thiosemicarbazone(129).…”

mentioning

confidence: 99%

Metal complexes driven from Schiff bases and semicarbazones for biomedical and allied applications: a review

Joshi

Mishra

et al. 2019

Materials Today Chemistry

217

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“…Pyridine based cobalt metal complex were synthesized and characterized by Xiao et al [15]. The pyridine-metal complex ( cell lines in comparison to their corresponding organic ligand [15].…”

Section: Introductionmentioning

confidence: 99%

Schiff Base Metal Complexes as Anticancer Agents

Sridevi

Antony

R³

2019

Asian J. Chem.

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Cutting-edge practices in bioinorganic chemistry are pivotal for enhancing the layout of compounds to lessen poisonous facet effect and recognize their mechanism of action. A powerful anticancer agent should own inherent, inhibitory property and also delivery, dosage and residence time in vivo. Organic function and conformation of mutated gene may be altered by way of binding of metal ions. Upswing of activities counting on the structural data, intending in enhancing and growing different forms of metal based compounds, continuous seek of extra metal based compounds have been synthesized via revamping the prevailing chemical shape via ligand substitution. The prevailing paper addresses the trendy development in the design of novel antitumor agents primarily based on transition metal complex via highlighting the near dating among their structural alternatives and cytotoxic ability.

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“…The in vitro cancer studies of all the compounds were assessed for their anti-proliferation test against a panel of selected human cancer cell lines such as HOP62 (lung) and BT 474 (breast) by using SRB (sulforhodamine B) assay [28][29][30][31][32][33][34][35][36][37] concentration of drug used 10, 20, 40, and 80 μg/mL ADR (adrimycin) was used as a positive control which controls cells with definite structure and clear cell wall without degeneration. Each drug was assayed inducing 50% growth inhibition (GI 50 ), total growth inhibition (TGI), and 50% cytotoxicity (LC 50 ) after a 48 h incubation period were calculated by linear interpolation from the observed data points.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, characterization, and biological studies of some biometal complexes

Srivastava

2021

Futur J Pharm Sci

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Background Metal complexes Cu[C13H8O4N]22, Ni[Cl3H8O4N]23, and Co[C13H8O4N]24 of bioinorganic relevance have been synthesized with the Schiff base ligand 2-furylglyoxal–anthranilic acid (FGAA) [C13H9O4N] 1. All the complexes are well characterized by various spectral and physical methods. The antimicrobial activity of the complexes has been studied against some of the pathogenic bacteria and fungi. Results Results indicate that complexes have higher antimicrobial activity than the free ligand. This would suggest that chelation reduces considerably the polarity of the metal ions in the complexes which in turn increases the hydrophobic character of the chelate and thus enables permeation, through the lipid layer of microorganisms. All the complexes were assessed for their anticancer studies against a panel of selected cancer cells HOP62 and BT474 respectively. Results showed that the complexes are promising chemotherapeutic alternatives in the search of anticancer agents. The fluorescence quenching phenomenon is observed in the Schiff base metal complexes. Conclusion The octahedral transition metal complexes 2, 3, and 4 have been obtained by treatment of ligand 2-furylglyoxal-anthranilic acid (FGAA) 1 with metal acetate. Complexes under investigations have shown antimicrobial, potential anticancer, and the DNA binding studies. Graphical abstract

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Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells

Cited by 9 publications

References 10 publications

Metal complexes driven from Schiff bases and semicarbazones for biomedical and allied applications: a review

Metal complexes driven from Schiff bases and semicarbazones for biomedical and allied applications: a review

Schiff Base Metal Complexes as Anticancer Agents

Synthesis, characterization, and biological studies of some biometal complexes

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