Effect of vitamin D therapy in addition to amitriptyline on migraine attacks in pediatric patients

Çayır, Atilla; Turan, Mehmet İbrahim; Tan, Hüseyin

doi:10.1590/1414-431x20143606

Cited by 53 publications

(27 citation statements)

References 40 publications

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“…Although vitamin D has been reported to improve migraine in small studies, 48, 49 most evidence fails to support an association between serum Vitamin D concentration and migraine or migraine severity. 22, 50, 51 Notably, one study found a positive, although weak, relationship between vitamin D concentration and a measure of migraine severity.…”

Section: Discussionmentioning

confidence: 99%

Comorbidity of Migraine, Major Depressive Disorder, and Generalized Anxiety Disorder in Adolescents and Young Adults

et al. 2016

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Objectives This study aims to examine the association between migraine, major depressive disorder (MDD), and generalized anxiety disorder (GAD) in adolescents and young adults. Background MDD, GAD, and migraine are often comorbid, with adult migraineurs having twice the rate of MDD as nonmigraineurs and more disabling migraines. Findings in children are less consistent; but anxiety disorders, including GAD, are prevalent among youth. Data on the association between MDD, GAD and migraine in adolescents and young adults are sparse. Methods Participants (N=227), between 15 and 20 years old, who were unmedicated or within one month of beginning antidepressant treatment underwent a comprehensive assessment to establish the presence of MDD and GAD, according to the Diagnostic & Statistical Manual, Fourth Edition, Text Revision, and to rate their symptom severity using the Longitudinal Interval Follow-up Evaluation for Adolescents. They then completed the ID Migraine. The Student’s t test and chi-square test were used to compare continuous and categorical variables, respectively, across participants with vs. without migraine. Logistic regression analysis examined the association between the presence of migraine and psychopathology. Results A diagnosis of MDD was associated with significantly increased risk of having migraine. Moreover, more severe and persistent ratings of depression were associated with an even higher likelihood of having migraine. A diagnosis of GAD was also significantly associated with the presence of migraine. The prevalence of comorbid MDD and GAD was significantly higher in participants with migraine than in those without migraine (55% vs. 22%, p<0.0001). When examined concurrently, GAD remained significantly associated with migraine, with a statistical trend for MDD to be associated with it. The use of selective serotonin reuptake inhibitors did not significantly alter these findings and serum vitamin D concentration was not associated with any of the disorders. Conclusions The comorbidity of migraine, MDD, and GAD has important clinical and research implications. Shared psychological and biological vulnerabilities may be involved in the three conditions. Greater understanding of the shared vulnerabilities can lead to unified treatments. ClinicalTrials.gov Identifier NCT02147184

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Section: Discussionmentioning

confidence: 99%

Comorbidity of Migraine, Major Depressive Disorder, and Generalized Anxiety Disorder in Adolescents and Young Adults

et al. 2016

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“…A few studies have also demonstrated beneficial effects of Vitamin D supplementation (with other drugs) in headache frequency and intensity,7 8 although a few conflicting observations have also been reported in the literature 18. The literature on the relation between vitamin D and tension-type headache is sparse.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency mimicking chronic tension-type headache in children: Table 1

Prakash¹,

Makwana

Rathore

2016

BMJ Case Reports

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Headache, musculoskeletal pain and vitamin D deficiency, with possible inter-relationship, are common in the general population. We report cases of three premenarchal girls presenting with chronic tension-type headache and generalised body pain. The patients did not show any response to conventional therapy for tension headache. Investigations showed a severe vitamin D deficiency and biochemical osteomalacia in all three patients. The headaches and musculoskeletal pain responded markedly to vitamin D therapy. We suggest that musculoskeletal pain and headache together in a patient may be part of a single symptom complex, with vitamin D deficiency being the possible cause.

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“…Lower 25-OH vitamin D levels were related to greater pain severity [80]. In a small prospective controlled essay in pediatric patients, vitamin D supplementation (with previous insufficiency, deficiency, or even normal serum levels) in addiction to amitriptyline, reduced the number of migraine attacks [81]. Recent treatment trials involving chronic pain patients, mostly FMS, have shown that deficient, or insufficient, levels of 25-OH vitamin D3, correlates with greater pain intensity and worse scores in quality of life questionnaires.…”

Section: Vitamin Dmentioning

confidence: 99%

Restless Legs Syndrome and Pain Disorders: What’s in common?

Goulart

Rodrigues

Peres

2014

Curr Pain Headache Rep

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Between 10 % and 30 % of the population report chronic pain. More than half of these also have sleep complaints. From considering these data, it can be inferred there is a significant overlapping between these conditions. Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is characterized by complaints of an "urge to move" frequently associated with dysesthesias. From that perspective, these sensations can also have painful characteristics. By the same token, the presence of comorbid diseases as predicted by a higher prevalence RLS/WED, have many of them with pain as an important complaint. Pain is a multidimensional response involving several levels of expression ranging from somatosensory to emotional. The potential shared mechanisms between RLS/WED and pain may involve sleep deprivation/fragmentation effect, inducing an increase in markers of inflammation and reduction in pain thresholds. These are modulated by several different settings of neurotransmitters with a huge participation of monoaminergic dysfunctional circuits. A thorough comprehension of these mechanisms is of utmost importance for the correct approach and treatment choices.

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Effect of vitamin D therapy in addition to amitriptyline on migraine attacks in pediatric patients

Cited by 53 publications

References 40 publications

Comorbidity of Migraine, Major Depressive Disorder, and Generalized Anxiety Disorder in Adolescents and Young Adults

Comorbidity of Migraine, Major Depressive Disorder, and Generalized Anxiety Disorder in Adolescents and Young Adults

Vitamin D deficiency mimicking chronic tension-type headache in children: Table 1

Restless Legs Syndrome and Pain Disorders: What’s in common?

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