Association of rs12255372 in theTCF7L2 gene with type 2 diabetes mellitus: a meta-analysis

Abstract

Our objective was to evaluate the association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus (T2DM) in the world population. We carried out a survey of the literature about the effect of rs12255372 on genetic susceptibility to T2DM by consulting PubMed, the Cochrane Library, and Embase from 2006 to 2012, and then performed a meta-analysis of all the studies in order to evaluate the association between rs12255372 and T2DM. A total of 33 articles including 42 studies (with 34,076 cases and 36,192 controls) were confirmed to be eligible and were included in the final meta-analysis: 6 studies conducted on Europeans, 14 on Caucasians, 17 on Asians, 2 on Africans, and 3 on Americans. Overall, the effect size was as follows: for the variant allele T (OR = 1.387, 95%CI = 1.351-1.424), for the TT genotype (OR = 1.933, 95%CI = 1.815-2.057), for the GT genotype (OR = 1.363, 95%CI = 1.315-1.413), for the dominant model (OR = 1.425, 95%CI = 1.344-1.510), and for the recessive model (OR = 1.659, 95%CI = 1.563-1.761). In summary, by pooling all available qualified data from genetic studies on rs12255372 and T2DM, we have confirmed that rs12255372 is significantly associated with susceptibility to T2DM in the global population.

Design of an allele-specific PCR assay to genotype the rs12255372 SNP in a pilot study of association between common TCF7L2 polymorphisms and type 2 diabetes in Venezuelans

“…(39) found that TCF7L2 rs7903146 and rs12255372 variants did not make major contributions to the incidence of glucose tolerance abnormalities in Japanese-Brazilians, a population with a high prevalence of T2DM. Finally, recent large meta-analyses confirmed that the rs12255372 SNP is significantly associated with susceptibility to T2DM in the global population, although in some ethnic populations, no significant associations were found (36,38,40).…”

“…Moreover, numerous studies and meta--analyses examining various ethnic groups demonstrated an association between TCF7L2 SNPs and T2DM and, although with some inconsistent results, the two TCF7L2 polymorphisms and type 2 diabetes risk Arch Endocrinol Metab. 2016;60/3 most highly correlated are rs7903146 and rs12255372 (36)(37)(38).…”

Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population

“…These studies have further confirmed the association of TCF7L2 gene variants with the susceptibility toT2DM in populations of different ethnic origins, including: British (Groves et al, 2006), Dutch (van Vliet-Ostaptchouk et al, 2007), Amish (Damcott et al, 2006), Finnish (Scott et al, 2006), Swedish (Mayans et al, 2007), French (Cauchi et al, 2006), American (United States) (Zhang et al, 2006), Indian (Chandak et al, 2007), and Japanese (Hayashi et al, 2007). A meta-analysis using a total of 33 articles including 42 studies (with 34,076 patients and 36,192 controls) has confirmed that rs12255372 is significantly associated with the susceptibility to T2DM in the global population (Wang et al, 2013a). In agreement with this notion, we also found a strong association of this locus with T2DM in this report.…”

Association of polymorphism rs7903146 gene TCF7L2 with low concentrations of autoantibodies in latent autoimmune diabetes of adults (LADA)

“…TCF7L2 может оказывать влияние на пролиферацию и дифференцировку β-клеток. Была продемонстрирована выраженная ассоциация полимор-физмов гена TCF7L2 -rs12255372 и rs7903146 с развитием СД2 [5,6,7], что не было отмечено при СД1 [8,9].…”