Adaptação transcultural do instrumento PAIR: Pharmacotherapy Assessment in Chronic Renal Disease para aplicação no Brasil

Abstract

Resumo Indivíduos com doença renal crônica (DRC) frequentemente utilizam polifarmácia o que os expõe ao risco de problemas relacionados a medicamentos (PRMs). No Brasil, não existem instrumentos que possam sistematizar a avaliação da farmacoterapia e a gestão de PRMs nesta população. Portanto, o objetivo deste trabalho foi realizar a adaptação transcultural do instrumento PAIR (Pharmacotherapy Assessment in Chronic Renal Disease) para o português brasileiro. O PAIR consiste numa lista de 50 PRMs considerados clinicamente significativos para renais crônicos. O processo de adaptação transcultural envolveu as etapas de tradução, síntese, retrotradução, análise por um comitê de especialistas e pré-teste da versão preliminar. O comitê de 2 farmacêuticos e 2 nefrologistas analisou a equivalência semântica, idiomática, experiencial e conceitual entre as versões original e traduzida. Todos os itens que obtiveram acordo inferior a 80% foram revisados. Foram realizados ajustes de palavras, assim como a exclusão de 6 PRMs devido à não aplicabilidade ao contexto brasileiro. Assim, foi obtida a versão final do PAIR definida como “Avaliação da farmacoterapia na doença renal crônica”, traduzida e adaptada na língua portuguesa do Brasil.

Pharmacotherapy assessment in chronic kidney disease: validation of the PAIR instrument for use in Brazil

“… 10 This instrument was recently translated and cross-culturally adapted to Brazilian Portuguese in our service. 23 …”

“…Problems related to non-prescription drugs or natural health products. 23 The instrument, in this format, works as a checklist, so that the pharmacist can evaluate the pharmacotherapy of these individuals, identify possible DRP and intervene in their resolution, being important to optimize the clinical results expected by the doctor. This assessment can be made using data provided by the patient himself, in consultation, and/or by data recorded in medical records.…”

“…Due to the fact that there is no instrument available in Brazil to guide the evaluation of pharmacotherapy, specifically in the population of patients with CKD, our group performed the translation and cross-cultural adaptation of PAIR at an initial phase ( Chart 1 ). 23 …”

“…18,19,20,21,22 Due to the fact that there is no instrument available in Brazil to guide the evaluation of pharmacotherapy, specifically in the population of patients with CKD, our group performed the translation and cross-cultural adaptation of PAIR at an initial phase (Chart 1). 23 The present study aimed to validate the PAIR, assessing its reliability, validity and responsiveness, as well as the prevalence of DRP in a sample of patients with CKD undergoing conservative treatment at a local nephrology outpatient service. 1.…”

Response to the article “Pharmacotherapy assessment in chronic kidney disease: validation of the pair instrument for use in Brazil”

“…In the present study, in line with the regulations for the validation of foreign language instruments 3 , 4 , we sought to remain strictly consistent with the original instrument 5 , which is why fundamental issues such as those mentioned in the letter to the editor were not included. The inclusion of new drug-related problems (DRPs) to the list of criteria in the PAIR would imply the use of a specific methodological proposal, which would cause a change to the original proposal of the PAIR creators.…”