Biological Enhancements for Anterior Cruciate Ligament Reconstruction

Leite, Chilan Bou Ghosson; Demange, Marco Kawamura

doi:10.1590/1413-785220192706226481

Cited by 9 publications

(12 citation statements)

References 59 publications

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“…The anterior cruciate ligament (ACL) ensures proper stabilization of the knee and is a passive limiter of excessive translation of the anterior tibia. ACL injury causes pain, which significantly reduces the patient’s quality of life [ 58 ]. Despite many methods of treatment, surgical reconstruction of the ACL has remained the gold standard in the treatment of patients with ACL trauma for many years [ 59 ].…”

Section: Resultsmentioning

confidence: 99%

Vitamin D Metabolic Pathway Components in Orthopedic Patientes—Systematic Review

Płomiński

Grzybowski

Fiedorowicz

et al. 2022

IJMS

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Vitamin D takes part in the functioning of many processes that ensure the homeostasis of the body. In orthopedics, it is indicated as an inseparable element ensuring proper bone growth and functioning, and its deficiencies are indicated in various diseases, mainly in the proper structure and function of the skeleton. In this review, we focus on the most important components of the vitamin D metabolic pathway, in correlation with selected orthopedic conditions. Records were obtained from the PubMed database in a timeline of 2010–2022. The keywords were as follows: vitamin D/cholesterol/vitamin D binding protein/ VDBP/Cytochrome/CYP24A1/CYP 27B1/Vitamin D receptor/VDR/ + diseases (ACL reconstruction, rotator cuff, arthroplasty knee/hip/shoulder). The recent original studies were analyzed, discussed, and the most important data were shown. The vast majority of articles concern the metabolite of vitamin D (25(OH)D), which is measured as a standard in diagnostic laboratories. Even though there is a lot of valuable information in the literature, we believe that the other elements of the vitamin D pathway also deserve attention and suggest their research in correlation with orthopedic disorders to supplement the missing knowledge on this topic.

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Section: Resultsmentioning

confidence: 99%

Vitamin D Metabolic Pathway Components in Orthopedic Patientes—Systematic Review

Płomiński

Grzybowski

Fiedorowicz

et al. 2022

IJMS

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“…The above‐mentioned process is what usually occurs in “tendon to tendon” healing (Thomopoulos et al, 2015). In contrast, when “tendon to bone” healing occurs (as observed after the reconstruction of the anterior cruciate ligament [ACL]), an increased density of Sharpey‐like fibers is observed, and a disorganized collagen structure is produced, binding the tendon to the bone (C. B. G. Leite & Demange, 2019; Thomopoulos et al, 2015). In this setting, osteoclasts are also recruited to the injured site, triggering bone resorption and improving tendon attachment (Zelzer et al, 2014).…”

Section: The Healing Process In the Kneementioning

confidence: 99%

“…Besides the attempts for an optimal recuperation of the joint function, the knee healing process is not always satisfactory. Thus, different therapeutic approaches have been suggested to improve knee healing capacity, including biological and biophysical interventions (C. B. G. Leite & Demange, 2019). Among the different strategies, Hyperbaric oxygen therapy (HBOT) arises as a new potential biophysical adjunctive therapy for knee injuries.…”

Section: Introductionmentioning

confidence: 99%

Revisiting the role of hyperbaric oxygen therapy in knee injuries: Potential benefits and mechanisms

Leite

Tavares

Leite

et al. 2023

Journal Cellular Physiology

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Knee injury negatively impacts routine activities and quality of life of millions of people every year. Disruption of tendons, ligaments, and articular cartilage are major causes of knee lesions, leading to social and economic losses. Besides the attempts for an optimal recovery of knee function after surgery, the joint healing process is not always adequate given the nature of intra-articular environment. Based on that, different therapeutic methods attempt to improve healing capacity. Hyperbaric oxygen therapy (HBOT) is an innovative biophysical approach that can be used as an adjuvant treatment post-knee surgery, to potentially prevent chronic disorders that commonly follows knee injuries. Given the well-recognized role of HBOT in improving wound healing, further research is necessary to clarify the benefits of HBOT in damaged musculoskeletal tissues, especially knee disorders. Here, we review important mechanisms of action for HBOT-induced healing including the induction of angiogenesis, modulation of inflammation and extracellular matrix components, and activation of parenchyma cells-key events to restore knee function after injury. This review discusses the basic science of the healing process in knee injuries, the role of oxygen during cicatrization, and shed light on the promising actions of HBOT in treating knee disorders, such as tendon, ligament, and cartilage injuries.

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“…Биологическую несостоятельность трансплантата ПКС можно подозревать у пациентов с рецидивирующей нестабильностью в коленном суставе при условии исключения других причин (до 17 % случаев) [42]. Биологическая интеграция трансплантата протекает через стадии асептического воспаления, включая этап реваскуляризации и ремоделирования его структуры [43].…”

Section: биологические факторыunclassified

The reasons for revision surgery after reconstruction of the anterior cruciate ligament: a systematic review

Saprykin¹,

Gvozdev²,

Рябинин³

et al. 2021

Sibirskij nauchnyj medicinskij zhurnal

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Reconstruction of the anterior cruciate ligament (ACL) is a fairly successful surgical intervention that can achieve satisfactory results in 75-97 % of cases. In order to show the main categories of factors that can affect the functional outcomes of patients after ACL reconstruction and lead to unsatisfactory outcomes after surgery based on the literature data, we have run a search for English- and Russian-language publications in the electronic databases PubMed and RSCI for the period from 2000 to 2019 using the keywords: anterior cruciate ligament, ACL, revision, re-reconstruction, re-injury, re-rupture, graft failure. Out of 634 papers, 113 publications with the full text were selected. Inclusion criteria - more than 50 cases in the report; follow - up period of more than 2 years; the same groups of patients; assessment of knee joint function; application of various imaging options for the knee joint. 26 papers were included in this review. Based on the analysis of the multiple causes of failed ACL reconstruction outcomes were merged into four main groups: technical mistakes diagnosis and surgery (from 22 % to 79 %); re-injury (18 % to 79 %); biological factors (violation of the integration of the graft and its ligamental) (17 %); errors of rehabilitation and other (15 %). Thus, the review made it possible to systematize the causes of unsuccessful outcomes of ACL reconstruction and identify the most frequent.

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Biological Enhancements for Anterior Cruciate Ligament Reconstruction

Cited by 9 publications

References 59 publications

Vitamin D Metabolic Pathway Components in Orthopedic Patientes—Systematic Review

Vitamin D Metabolic Pathway Components in Orthopedic Patientes—Systematic Review

Revisiting the role of hyperbaric oxygen therapy in knee injuries: Potential benefits and mechanisms

The reasons for revision surgery after reconstruction of the anterior cruciate ligament: a systematic review

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