Primary Bone Lymphomas: Retrospective Analysis of 42 Consecutive Cases

Abstract

Objective:It is difficult to define parameters for management and factors associated with primary bone lymphoma (PBL). This article presents the experience in a single institution with 42 patients with PBL over a 16-year period (2000-2016). Methods:Fifty-five patients were retrospectively evaluated, and forty-two were included (76.3%). Results:Median age at diagnosis was 51.5 years, and median follow-up was 102.7 months. One patient had HIV. Pain in the affected site was the most prevalent symptom. The average time between symptom onset and diagnosis was 5.4 months. The vertebrae were most affected (n=16, 33.3%). According to the International Prognostic Index Score (IPI), 64.3% of the patients were classified as having low-grade lymphoma and 25.7% as low-intermediate. The most common histology was diffuse large B cell lymphoma (DLBCL) (85.7%). Immunophenotyping was CD20 positive in 93.5% of patients, and 11 patients had pathological fracture. All patients received chemotherapy and 30% of the regimens included rituximab. Thirty-eight percent of patients received radiation therapy. Overall survival was 50%, and survival median time was 80 months. Age and chemotherapy regimen influenced patient survival. Younger patients and patients who received RCHOP had better prognoses. Conclusions:The choice of chemotherapy regimen associated with age influenced survival for patients with PBL. Level of Evidence IV; Case series.

Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype

“…[2][3][4][5][6][7][8][9] Most patients present with symptoms of pain, bone fractures, localized swelling, or suspected periprosthetic joint infection. [10][11][12][13] Patients ' physical performance can be affected because weight-bearing bones are commonly involved (eg, femur, spine, pelvis). 2,6,13 Between studies, reported clinical characteristics and survival rates are diverse due to a lack of strict (anatomical) definitions and consequent proper classification of DLBCL with osseous involvement (O-DLBCL).…”

Primary Bone Lymphomas: Long-Term Results of a Prospective Single-Center Trial

“…Однако очевидно, что значительная часть событий у пожилых пациентовэто летальный исход по причине, не связанной с опухолью. Кроме того, тяжелая переносимость химиотерапии и сопутствующие заболевания, связанные с возрастом, существенно ограничивают врача в выборе возможных вариантов лечения [21,32,[39][40][41][42].…”

Multiple osteolytic lesions due to Double-Expressor Primary non-Hodgkin Lymphoma of the Bone

“…The current treatment options include a combination of immunochemotherapy and radiation. 3,4 However, due to the rarity of the disease, there is no consensus on the best therapeutic management. Here, we report the case of a 74 years-old female patient with PLB and multiple osteolytic lesions.…”