IMUNOMARCAÇÃO DE TGF-β EM PRÓSTATAS CANINAS NORMAIS E COM LESÕES PROLIFERATIVAS

Toledo, Denise Caroline; Faleiro, Mariana Batista Rodrigues; Ferreira, Hugo Henrique; Faria, Adriana Marques; Matos, Manuela; Amorim, Renée Laufer; Moura, Veridiana Maria Brianezi Dignani de

doi:10.1590/1089-6891v20e-34543

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Despite exhibiting heterogeneous labeling for androgen receptors, basal cells in these lesions are believed to act in prostate tumor development with significant potential for proliferation [ 44 ]. Moreover, PIN exhibits an immunophenotype similar to PIA and canine PC with regard to cell cycle regulators [ 36 ], showing lower expression of TGF-β in epithelial cells and tissue stroma, referring to the impossibility of this cytokine to inhibit cell proliferation [ 45 ].…”

Section: Preneoplastic Prostatic Lesionsmentioning

confidence: 99%

Comparative Pathobiology of Canine and Human Prostate Cancer: State of the Art and Future Directions

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Amorim

Fonseca-Alves

et al. 2022

Cancers

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First described in 1817, prostate cancer is considered a complex neoplastic entity, and one of the main causes of death in men in the western world. In dogs, prostatic carcinoma (PC) exhibits undifferentiated morphology with different phenotypes, is hormonally independent of aggressive character, and has high rates of metastasis to different organs. Although in humans, the risk factors for tumor development are known, in dogs, this scenario is still unclear, especially regarding castration. Therefore, with the advent of molecular biology, studies were and are carried out with the aim of identifying the main molecular mechanisms and signaling pathways involved in the carcinogenesis and progression of canine PC, aiming to identify potential biomarkers for diagnosis, prognosis, and targeted treatment. However, there are extensive gaps to be filled, especially when considering the dog as experimental model for the study of this neoplasm in humans. Thus, due to the complexity of the subject, the objective of this review is to present the main pathobiological aspects of canine PC from a comparative point of view to the same neoplasm in the human species, addressing the historical context and current understanding in the scientific field.

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Section: Preneoplastic Prostatic Lesionsmentioning

confidence: 99%

Comparative Pathobiology of Canine and Human Prostate Cancer: State of the Art and Future Directions

Nascente

Amorim

Fonseca-Alves

et al. 2022

Cancers

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“…The function of TGFβ in the prostate is related to prostate growth and angiogenesis, and it has been shown to be associated with prostate cancer [14]. It accumulates in stromal cells, contributing to the progression of proliferative lesions that occur in the prostate [15]. However, Lee et al (1999) pointed out that the mode of action of TGFβ in prostatic tissue is variable [14].…”

Section: Introductionmentioning

confidence: 99%

Chronic effects of short-term aerobic and anaerobic physical training on the ventral prostate of adult rats

Rmr

ESd

et al. 2021

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Aims: To analyze the chronic effects of short-term aerobic and anaerobic physical training on prostate compartments, extracellular matrix, microvascularization, TGFβ, cyclooxygenase-2, inducible nitric oxide synthase (iNOS) and macrophage immunostaining, and ventral prostate histopathology in adult rats. Main methods: Fifteen male rats (90 days old) were divided into three groups (n = 5/group): sedentary, aerobic (AE) (swimming), and anaerobic physical training (AN) (jumping), performed three days per week, for 8-weeks. The animals were sacrificed within 21 weeks of age. The ventral prostate was collected, weighed, and processed for histological and immunohistochemical analyses. Key findings: Our results show that AE increases blood capillaries and reduces the percentage and increases the thickness of smooth muscle. AN promotes increased iNOS levels in the prostatic tissue, and both modalities reduce TGFβ and elastic fibers, in addition to being protective against benign prostatic hyperplasia and atrophy. Significance: Different physical training modalities can activate specific mechanisms that modify the prostate environment.

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IMUNOMARCAÇÃO DE TGF-β EM PRÓSTATAS CANINAS NORMAIS E COM LESÕES PROLIFERATIVAS

Cited by 2 publications

References 20 publications

Comparative Pathobiology of Canine and Human Prostate Cancer: State of the Art and Future Directions

Comparative Pathobiology of Canine and Human Prostate Cancer: State of the Art and Future Directions

Chronic effects of short-term aerobic and anaerobic physical training on the ventral prostate of adult rats

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