The significant increase and indiscriminate use of chemical
pesticides
have led to the development of several environmental problems and
adverse effects on human health. Alternatively, bioinsecticides have
been successfully used for a variety of crops to control several insect
infestations with efficiency and competitive costs. Metarhizium
anisopliae have widely been used in sugar cane crops in Brazil,
and their use is the most successful enthomopathogen program worldwide.
However, the production of this propagule is semiartisanal and presents
several technical bottlenecks. In order to intensify this production,
all the steps of the process have been revised and more efficient
techniques and procedures have been adopted to avoid exogenous contamination
and increase the productivity. The most relevant modification in this
semicontinuous process is the cultivation of rice in packed-bed solid-state
cultivation bioreactors and the extraction of spores in rotating drums,
with retention of the spores in cyclones. The economic analysis showed
that this process is competitive when compared with the traditional
process of spore production and with similar biotechnological processes.