Araçá (Psidium cattleianum Sabine): bioactive compounds, antioxidant activity and pancreatic lipase inhibition

Abstract

“Araçá” has been reported with different biological activities such as antioxidant, antiproliferative and antimicrobial as well as inhibitors of digestive enzymes. The digestive pancreatic lipase enzyme plays a fundamental role in lipid metabolism, and its inhibition has been studied as a target for obesity treatment. This study quantified the bioactive compounds present in different parts of “araçá” fruit and evaluated their antioxidant activity and lipase inhibition properties. Three samples were analyzed for total anthocyanins, total phenolic content, antioxidant activity and pancreatic lipase inhibition. Anthocyanins were reported only in pulp-peel of red “araçá” sample. Phenolic compounds concentration was higher in pulp-peel than in seeds for all samples. The antioxidant activity followed the same trend. A positive correlation was observed between total phenolic content and both antioxidant activity and lipase inhibition. Lipase inhibition activity was higher for pulp-peel compared to the seeds. Overall, the results showed that “araçá” fruit extracts could be beneficial for the treatment of obesity.

An Integrative Review on the Main Flavonoids Found in Some Species of the Myrtaceae Family: Phytochemical Characterization, Health Benefits and Development of Products

“…For the identification and/or quantification of these bioactive constituents in the different extracts evaluated, the following methods were employed: spectrophotometry [ 3 ], LC-DAD-ESI-MS/MS [ 47 ], UPLC/QTOF/MS [ 42 , 50 ], PS-MS [ 4 ], liquid chromatography [ 56 ], and HPLC-DAD-ESI/MS [ 37 , 58 , 59 ], among others.…”

“…In addition to the properties of araçá, Vinholes et al [ 94 ] concluded that extracts from the genotypes of yellow and red araçás are excellent sources of bioactive compounds, especially anthocyanins, which show promising inhibition of α-glucosidase and help to lower blood glucose in patients with type 2 diabetes mellitus. In turn, Pereira et al [ 3 ] quantified the bioactive compounds present in different parts of the araçá fruit, and evaluated their antioxidant activity and lipase inhibition properties; according to the authors, araçá fruit extracts can be beneficial for the treatment of obesity. Saber et al [ 42 ] verified the efficacy of P. guajava and P. cattleianum leaf extracts and their nano-liposomes in improving paracetamol-induced hepatotoxicity in rats.…”

“…Several species have significant economic and technological value, such as eucalyptus ( Eucalyptus spp. ), used in the production of wood and flavoring agents [ 2 ], as well as numerous fruit plants, such as the araçazeiro ( Psidium cattleianum Sabine) [ 3 ], cambuizeiro ( Myrciaria floribunda (H. West ex Willd.) O. Berg) [ 4 ], gabirobeira ( Campomanesia xanthocarpa (Mart.)…”

In Vitro Antilipidic and Antithrombotic Activities of Plectranthus glandulosus (Lamiaceae) Leaves Extracts and Fractions

“…The interaction of phenolic compounds with cholesterol esterase is due to the presence of potent cholesterol esterase inhibitory sites, especially the interaction with the catalytic triad and oxyanion hole residues [ 49 ]. Our previous study also reported that hydroethanolic extract and ethyl acetate fraction have antioxidant properties [ 28 , 29 ], and it is shown that a positive correlation exists between phenolic compounds, antioxidant activity of plant extracts, and digestive enzyme inhibitory activity [ 50 , 51 ].…”

Antihyperlipidemic Activity of Purified Polyphenol Extracted from Water Lettuce (Pistia stratiotes) Leaf: An In Vitro Analysis

“…A previous study reported that polyphenol compounds from several plants have been reported for their potential lipase-inhibitory activities. 8,29 A previous study also reported that the quality or bioactivity of crude extract was increased after purification. 30…”