Canine ovarian dysgerminoma

Abstract

This research aimed to describe a clinical case of ovarian dysgerminoma in a bitch, by showing clinical, ultrasound, surgical and pathological findings. The research also sought to emphasize the importance of establishing an early and definitive diagnosis through histopathology, establishing appropriate protocols for each patient. Ovarian tumors have a low incidence in dogs and cats. Dysgerminomas are a type of ovarian germ cell tumor. They develop in dogs of variable age, that may present clinical signs of hormonal imbalance such as persistent estrus, or pyometra. Prognosis is good in animals that undergo surgery and show no evidence of metastasis. This article presents a clinical case of a 6-year-old English Bulldog with persistent estrus for 2 months, and slightly depressed mental state. Ultrasound revealed the presence of a mass on the left ovary and uterine content. Ovariohysterectomy was performed and the mass was submitted to histopathological exam, which diagnosed an ovarian dysgerminoma.RESUMO: Neste trabalho descrevem-se caso clínico, achados de ultrassom, cirúrgicos e patológicos de disgerminoma ovárico em cadela. Os tumores ováricos têm baixa incidência em cães e gatos. Nesta categoria estão os tumores das células germinativas, a partir das quais se desenvolvem os disgerminomas. Acomete cadelas de idades variáveis, que podem apresentar sinais clínicos indiciando alterações hormonais, como cio persistente, ou piometra. O prognóstico em animais tratados cirurgicamente, sem evidência de metástase, é bom. Esta pesquisa relata um caso clínico em cadela, raça Bulldog Inglês, de 6 anos de idade, com presença de cio persistente por dois meses. O ultrassom revelou a presença de massa ao nível do ovário esquerdo e escasso conteúdo uterino. Foi realizada ovariohisterectomia e a peça cirúrgica foi enviada para anatomia patológica, que diagnosticou disgerminoma ovarico. Após a resolução do caso, ressalta-se a importancia do diagnóstico clinico e histopatológico precoce para estabelecer protocolos de tratamento adequados. Palavras-chave: neoplasias ovaricas, disgerminoma, tumor canino. CLINIC AND SURGERY

Imaging of Canine Neoplastic Reproductive Disorders

“…When the ovary is significantly enlarged, it results in a ventrally located mass that causes medial, but not ventral displacement of adjacent organs on radiographs. Right ovarian masses displace the descending duodenum and ascending colon medially, whereas left ovarian masses displace the descending colon medially [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Peritoneal or pleural effusion may be present when there are either benign or malignant masses [ 2 , 13 ].…”

“…The size of the anechoic cavities ranged from 0.2 to 3.5 cm in diameter. The solid parenchyma had a fairly uniform appearance in all [ 5 , 7 , 8 ]. Teratomas are often cystic and may show partial mineralisation with distal shadowing, due to structures such as hair, skin, sweat glands, cartilage, bone, and teeth, which might help to distinguish these tumours from other ovarian masses.…”

Metastatic mammary tubulopapillary carcinoma in a captive black jaguar (Panthera onca)

“…In a recent report, Sal‐like protein 4, octamer‐binding transcription factor 3/4 and placental alkaline phosphatase have been successfully used to confirm the germ cell line in cases of dysgerminoma from a wild canid in comparison to domestic dogs 27 . Positivity for vimentin would also be expected in dysgerminomas, in contrast to CD3, CD79a, cytokeratin, alpha‐fetoprotein, inhibin and S‐100 28 . C‐kit immunolabelling would have also provided some useful information regarding its prognostic and predictive value 27 .…”

“…27 Positivity for vimentin would also be expected in dysgerminomas, in contrast to CD3, CD79a, cytokeratin, alpha-fetoprotein, inhibin and S-100. 28 C-kit immunolabelling would have also provided some useful information regarding its prognostic and predictive value. 27 Nevertheless, despite the overall importance of this immunohistochemical profile, it is not certain whether these markers are applicable for jaguars, and none of these markers were readily available for the current report.…”