Facial nerve ganglioneuroblastoma in a feline leukemia virus-positive cat

Abstract

Neuroblastic tumors can originate from the central neuraxis, olfactory epithelium, adrenal medullary region or autonomous system. Ganglioneuroblastoma are a type of neuroblastic tumor, with very few case descriptions in animals. Diagnosis of facial nerve ganglioneuroblastoma was made in a feline leukemia virus-positive 11-month-old cat. The cat had hyporexia, left head tilt, depressed mental state, horizontal nystagmus, inability to retract the pinched left lip, anisocoria, ptosis, and absence of the menace reflex. Gross necropsy showed a mass at the left facial nerve root region. Histological examination of this mass showed neoplastic proliferation of neuroblasts arranged in a cohesive pattern and mature ganglion cells. Ganglion cells were positive for neurofilament, neuron-specific enolase, S100, and glial fibrillary acidic protein by immunohistochemistry, while neuroblasts were positive for vimentin, S100, neuron-specific enolase and feline leukemia virus.

Linfoma folicular de terceira pálpebra em um felino: Relato de caso de neoplasma raro associado à co-infecção viral por calicivírus, FIV e FeLV

“…Diferente deste relato, os linfomas relacionados ao FeLV em geral são multicêntricos ou mediastinais e acometem gatos jovens; já, em associação com o FIV, geralmente são linfomas de células B, de alto grau de malignidade (Valli et al, 2017). Entretanto, o vírus FeLV tem sido considerado o mais significativo vírus indutor de tumores em felinos (Hartmann, 2006;Matesco et al, 2013;Pereira et al, 2017).…”

Cholesteatoma and hydrocephalus associated to a third ventricle meningioma in a cat

“…Multiple samples of the organs were collected and fixed in 10% neutral buffered formalin, routinely processed for histology and stained with hematoxylin and eosin (HE). Cut sections of the third ventricular mass were submitted to immunohistochemistry exams (IHC) with the following antibodies according to previously described protocols (PEREIRA et al, 2017): cytokeratin (clone AE1/AE3; 1:80; DakoCytomation), vimentin (clone V9; 1:200; Zymed) and S100 (1:200; DakoCytomation).…”

Spinal cord anaplastic meningioma with extra-neural metastasis in a cat

“…Multiple samples of organs were collected, fixed in 10% neutral buffered formalin, routinely processed for histology and stained with hematoxylin and eosin (HE). Cut sections of the masses involving the spinal cord and the lungs were submitted to IHC exam with the following antibodies, according to previously described protocols (PEREIRA et al, 2017): vimentin (clone V9; 1:200; Zymed), cytokeratin (clone AE1/AE3; 1:80; DakoCytomation), S100 (1:200; DakoCytomation) and glial fibrillary acidic protein (GFAP; 1:500; DakoCytomation). Reactions were revealed with 3,3'diaminobenzidine chromogen (DAB; DakoCytomation) and counterstained with Harry's hematoxylin.…”