Spontaneous and experimental poisoning of cattle by Palicourea aeneofusca in the region of Pernambuco and induction of conditioned food aversion

Brito, Luiz B.; Albuquerque, Raquel F.; Rocha, Brena P.; Albuquerque, Samuel Salgado Cavalcanti de; Lee, Stephen Thomas; Medeiros, Rosane M.T.; Riet-Correa, Franklin; Mendonça, Fábio de Souza

doi:10.1590/0103-8478cr20150079

Cited by 8 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The aforementioned authors concluded that aversion to P. aeneofusca began five days after treatment commencement and persisted for up to 90 days (Oliveira et al 2014). Brito et al (2016) tested the technique of conditioned food aversion to P. aeneofusca in cattle. To this end, animals were divided into two groups of six: one group was composed of animals treated with LiCl at a dose of 175mg/kg shortly after consumption of P. aeneofusca leaves and the other group comprised animals that received 1mL/kg of water, following the same methodology used for the other group.…”

Section: Use Of Conditioned Food Aversion To Prevent Ingestion Of Mfa-containing Plantsmentioning

confidence: 99%

“…Among the plants that cause sudden death and contain MFA, the most important and responsible for outbreaks of ruminant poisoning in Brazil are P. marcgravii, found in practically all Brazilian territory, except for the southern, semi-arid and northeastern states, and Mato Grosso do Sul state (Tokarnia et al 2012); P. aeneofusca, which is present in the states of Paraíba, Pernambuco, Alagoas and Bahia (Brito et al 2016); A. septentrionalis, formerly Mascagnia rigida (Davis & Anderson 2010), found mainly in the caatinga, on rocky outcrops, in the states of Pernambuco, Alagoas, Rio Grande do Norte, Paraiba and Ceará. A. septentrionalis is in the plants.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Techniques for prevention and control of poisoning by sodium monofluoroacetate (MFA)-containing plants in ruminants

2019

Self Cite

View full text Add to dashboard Cite

Monofluoroacetate (MFA)-containing plants cause sudden death associated with exercise in ruminants, and are responsible for significant losses in Brazilian livestock, estimated at 500,000 bovine deaths annually. Most of the times, the control and treatment of this type of poisoning are not efficient, because disease evolution is superacute, usually causing the death of the animal. Due to the difficulty in controlling this intoxication, several studies have suggested alternatives to prevent it, mainly by making animals resistant to the MFA present in these plants or by avoiding their consumption. This literature review addresses the techniques used experimentally to control the poisoning of ruminants by plants containing MFA. The first studies carried out in Brazil demonstrated that goats and sheep that continuously receive non-toxic doses of plant containing MFA show greater resistance to poisoning than untreated animals, and that this resistance can be transmitted by ruminal fluid transfaunation, suggesting that poisoning occurs due to the presence of bacteria that hydrolyze MFA in the rumen. Based on this hypothesis, several MFA-hydrolyzing bacteria were isolated (Enterococcus faecalis, Bacillus sp., Paenibacillus sp., Burkholderia sp., Cupriavidus sp., Staphylococcus sp., Ancylobacter sp., Ralstonia sp., Stenotrophomonas sp., Pigmentiphaga kullae, and Ancylobacter dichloromethanicus). When some of these bacteria were administered intraruminally, they provided the animal with a different level of protection against poisoning. However, it was observed that protection is gradually lost when the bacterium administration is interrupted. Consequently, to obtain more efficient protection, these bacteria should be administered continuously, probably in the form of probiotics. In another assay, MFA was administered to sheep at non-toxic doses to test the hypothesis that this substance could induce the multiplication of bacteria that hydrolyze it in the rumen. There was no increase in resistance to poisoning after administration of MFA; however, no signs of poisoning were observed when animals received trifluoroacetate and no clinical signs were verified when they were challenged with toxic doses of MFA; in contrast, all control animals presented clinical signs. These results suggest that trifluoroacetate induces the proliferation of MFA-degrading bacteria, and can be used in intoxication prophylaxis. The conditioned food aversion technique, using lithium chloride, has been successfully used experimentally to prevent ruminants from ingesting plants that contain MFA. Another alternative tested was the spraying of Amorimia septentrionalis with the endophytic bacterium Herbaspirillum seropedicae, which degrades MFA, resulting in decreased concentration of this compound in the plants. In conclusion, several experimental techniques have been proved efficient in the control and prophylaxis of MFA-containing plant poisoning; however, none of these techniques are available commercially. Further experiments, mainly in the field, should be carried out to adapt some of these techniques to the conditions of extensive breeding in the numerous areas where MFA-containing plants occur.

show abstract

Section: Use Of Conditioned Food Aversion To Prevent Ingestion Of Mfa-containing Plantsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Techniques for prevention and control of poisoning by sodium monofluoroacetate (MFA)-containing plants in ruminants

2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…Na intoxicação por P. aeneofusca descreveramse lesões inespecíficas no coração, tais como áreas difusas de hemorragia, edema das células de fibras de Purkinje e necrose coagulativa de fibras miocárdicas, com fibras em cariólise ou picnose, aumento da eosinofilia citoplasmática e perda das estriações transversais. Nos miocardiócitos podem ser observados vacúolos intranucleares discretos com marginalização da cromatina e nos espaços intersticiais pode haver edema discreto, depósitos de fibrina e infiltração de células mononucleares (Brito et al 2016, Arruda et al 2017. Possivelmente essas lesões também podem ser encontradas em outras intoxicações por plantas que contêm MFA.…”

Section: Sinais Clínicos Lesões Macro E Microscópicas Associadas àS unclassified

“…Em bovinos foi induzida experimentalmente aversão alimentar condicionada em condições de campo, administrando-se cloreto de lítio após a ingestão de P. aeneofusca. Nessa espécie, o efeito aversivo perdurou por 12 meses, mostrando-se um método eficaz (Brito et al 2016). Em ovinos (Pacífico da Silva & Soto-Blanco 2010) e caprinos (Barbosa et al 2008) a mesma técnica foi utilizada para prevenir a intoxicação por A. septentrionalis com resultados satisfatórios em condições experimentais.…”

Section: Diagnóstico Tratamento E Medidas Preventivas Ou De Controleunclassified

Plantas cardiotóxicas para ruminantes no Brasil

et al. 2018

Self Cite

View full text Add to dashboard Cite

RESUMO: Esta revisão atualiza informações sobre plantas cardiotóxicas que afetam os ruminantes no Brasil. Atualmente, sabe-se que existem pelo menos 131 plantas tóxicas pertencentes a 79 gêneros. Vinte e cinco espécies afetam o funcionamento do coração. As plantas que contêm monofluoroacetato de sódio (Palicourea spp., Psychotria hoffmannseggiana, Amorimia spp., Niedenzuella spp., Tanaecium bilabiatum e Fridericia elegans) causam numerosos surtos de intoxicação, principalmente em bovinos, mas búfalos, ovinos e caprinos são ocasionalmente afetados. A intoxicação por Palicourea marcgravii continua a ser a mais importante devido à ampla distribuição desta planta no Brasil. Novas espécies do gênero Palicourea contendo monofluoracetato de sódio, como Palicourea amapaensis, Palicourea longiflora, Palicourea barraensis, Palicourea macarthurorum, Palicourea nigricans, Palicourea vacillans e Palicourea aff. juruana foram descritas na região amazônica. Na região nordeste, a planta tóxica mais importante para bovinos é Amorimia septentrionalis. No Centro-Oeste, surtos de intoxicação por Niedenzuella stannea foram relatados em bovinos na região do Araguaia e a doença precisa ser melhor investigada quanto à sua ocorrência e importância. Tetrapterys multiglandulosa e Tetrapterys acutifolia, duas plantas que causam fibrose cardíaca, também contêm monofluoracetato de sódio e foram reclassificadas para o gênero Niedenzuella. Essas duas espécies e Ateleia glazioveana, outra planta que causa fibrose cardíaca, continuam sendo importantes no Sul e Sudeste do Brasil. Outras espécies menos importantes e que ocasionamente provocam surtos acidentais de intoxicação são as plantas que contém glicosídeos cardiotóxicos, tais como Nerium oleander e Kalanchoe blossfeldiana. Recentemente, várias metodologias experimentais foram empregadas para evitar intoxicações por plantas que contêm monofluoroacetato de sódio. Estas metodologias incluem a indução de aversão condicionada utilizando cloreto de lítio, a utilização de doses repetidas não tóxicas de folhas para induzir resistência, o uso de acetamida para prevenir as intoxicações e a inoculação intraruminal de bactérias degradantes de monofluoroacetato de sódio.

show abstract

“…The control and prophylaxis of this poisoning by traditional methods such as fencing infested areas or using herbicides is not efficient (Barbosa et al 2003). Therefore, some studies have already used several alternatives to render ruminants resistant to plant poisoning containing MFA, including: 1) the repeated administration of non-toxic doses of the plant containing MFA for alternate periods (Duarte et al 2014); 2) the transfer of ruminal fluid from ruminants inoculated with MFA-degrading bacteria, which became resistant to poisoning, to susceptible ruminants (Silva et al 2015); 3) the administration of MFA-degrading bacteria isolated from the rumen of animals, soil and plants containing MFA (Pessoa et al 2015, Silva et al 2016; 4) use of the conditioned aversion technique through the use of lithium chloride (Brito et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of resistance to natural poisoning by Amorimia septentrionalis in goats which had received sodium monofluoroacetate degrading bacteria

et al. 2018

Self Cite

View full text Add to dashboard Cite

Amorimia septentrionalis is an important sodium monofluoroacetate (MFA) containing plant that causes sudden death in ruminants in northeastern Brazil. MFA degrading bacteria are being used in the prevention against poisoning by this plant. The aim of this study was to evaluate if goats which had per os received MFA degrading bacteria remained resistant when exposed to natural poisoning by A. septentrionalis. Eighteen goats were randomly distributed into three groups: the goats of Group 1 previously received, during 40 days, a solution containing the bacteria Ralstonia sp. and Burkholderia sp., those goats in the Group 2 received the bacteria Paenibacillus sp. and Cupriavidus sp. and goats from Group 3 did not receive any bacteria. After the administration period, during 60 days, the animals of all groups were released to graze on a one hectare paddock, with significant amount of A. septentrionalis. They were observed daily for the spontaneous consumption of A. septentrionalis leaves and the occurrence of clinical signs of poisoning or sudden death. Goats from all groups consumed significant amounts of A. septentrionalis during the experimental period. Goats that did not receive MFA-degrading bacteria (Group 3) became sick and died from the 25th to the 27th day of the experiment, whereas the goats of the groups that received MFA-degrading bacteria showed only clinical sings when A. septentrionalis regrowth after the 55th day of the experiment. The days elapsed from field observation to death of Group 3 goats (25.5±0.9 days) were significantly lower (p<0.05) than Group 1 (58.6±1.3 days) and Group 2 (57.8±1.5 days). Thus, it can be concluded that administration of MFA degrading bacteria increases the resistance to natural poisoning by A. septentrionalis.

show abstract

Spontaneous and experimental poisoning of cattle by Palicourea aeneofusca in the region of Pernambuco and induction of conditioned food aversion

Abstract: The objective of this study was to describe the epidemiological, clinical, and pathological aspects of Palicourea aeneofusca poisoning in cattle in the region of Pernambuco, Brazil and to determine if it is possible to induce food aversion by

Cited by 8 publications

References 6 publications

Techniques for prevention and control of poisoning by sodium monofluoroacetate (MFA)-containing plants in ruminants

Techniques for prevention and control of poisoning by sodium monofluoroacetate (MFA)-containing plants in ruminants

Plantas cardiotóxicas para ruminantes no Brasil

Evaluation of resistance to natural poisoning by Amorimia septentrionalis in goats which had received sodium monofluoroacetate degrading bacteria

Contact Info

Product

Resources

About