2020
DOI: 10.1590/0103-6440202003024
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Experimental Acute Sepsis Reduced Number of Osteocalcin Immunolabeled Cells in Periodontal Ligament

Abstract: Abstract The aim of this study was to evaluate the effect of acute sepsis in the periodontal ligament, alveolar and furcation bone in absence of periodontitis induction through histological and immunohistochemical analyses. A septic rat model was established by cecal ligation and puncture (CLP). Twelve rats were randomly divided into CLP (n=6) and Sham (n=6) groups. The animals were euthanized at 24 h and hemimandibles were submitted to histomorfometric (bone matrix, collagenous fibers, fibroblasts, os… Show more

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“…Inflammatory indicators such as IL-6, IL-1 β , and IL-8 with an abnormal upward trend would aggravate the injury degree of vascular endothelial cells and further aggravate the inflammatory response of periodontal tissues, which may reduce the effect of drug treatment and increase the risk of treatment failure. (2) BGP was a hormone-like peptide mainly expressed by osteoblasts, which could promote bone resorption and reflect bone metabolism [ 16 ]. The abnormal increase of BGP in GCF in patients with severe periodontitis indicated severe alveolar bone damage, which may reduce the effect of drug treatment and increase the probability of ineffective treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Inflammatory indicators such as IL-6, IL-1 β , and IL-8 with an abnormal upward trend would aggravate the injury degree of vascular endothelial cells and further aggravate the inflammatory response of periodontal tissues, which may reduce the effect of drug treatment and increase the risk of treatment failure. (2) BGP was a hormone-like peptide mainly expressed by osteoblasts, which could promote bone resorption and reflect bone metabolism [ 16 ]. The abnormal increase of BGP in GCF in patients with severe periodontitis indicated severe alveolar bone damage, which may reduce the effect of drug treatment and increase the probability of ineffective treatment.…”
Section: Discussionmentioning
confidence: 99%