Effects of Diabetes and Hypertension on Oral Mucosa and TGFβ1 Salivary Levels

Bernardi, Lisiane; Souza, Bárbara Capitanio de; Sonda, Nicole Canalli; Visioli, Fernanda; Rados, Pantelis Varvaki; Lamers, Marcelo Lazzaron

doi:10.1590/0103-644020181868

Cited by 5 publications

(3 citation statements)

References 28 publications

(26 reference statements)

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“…Stage of embryogenesis TGFꞵ1 serves to break the branches of the salivary gland and has an important role in regulating the proliferation and differentiation of epithelial cells, this can affect homeostasis in the oral mucosa, and reduce salivary production. 30 In this study there was no significant relationship between DM and mucosal lesions. Mucosal lesions can also be found in a person due to daily habits, such as smoking, drinking alcoholic beverages and repeated trauma.…”

Section: Resultscontrasting

confidence: 52%

Analysis of Oral Chronic Kidney Disease with Hemodialysis Therapy in South Kalimantan - Indonesia

2019

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Chronic kidney disease (CKD) is a world health problem where the incidence continues to increase, has a poor prognosis and high-level financing. Clinical manifestations of the oral cavity can occur in CKD patients with hemodialysis therapy due to a decrease in the immune system. To analyze the descriptively the clinical manifestations of oral cavity in CKD patients with hemodialysis therapy at RSUD Ulin Banjarmasin South Kalimantan, period January-March 2019. This is a descriptive analysis with a cross sectional study design, based on history and clinical examination of the oral cavity. Data was entered and analyzed using chi square test. Sampling by purposive sampling. there is a relationship between uremic odor and duration of hemodialysis (p = 0.017). There was a relationship between xerostomia and gender (p = 0.035) and there was a relationship between xerostomia and the duration of hemodialysis (p = 0.007). There is a relationship between gingival swelling and age (p = 0.010) and there is a relationship between gingival swelling and diabetes mellitus (p = 0,000). Manifestations found in the oral cavity of CKD patients with hemodialysis therapy are uremic odor, mouthache, xerostomia, mucosal lesions, candidiasis, and gingival swelling. There is a relationship between sex with xerostomia, the relationship between age with gingival swelling, the relationship between the duration of hemodialysis with uremic odor and xerostomia, the association between DM with gingival swelling. Keywords: Chronic Kidney Disease, Clinical Manifestations, Hemodialysis, Oral Cavity

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Section: Resultscontrasting

confidence: 52%

Analysis of Oral Chronic Kidney Disease with Hemodialysis Therapy in South Kalimantan - Indonesia

2019

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“…In the process of embryogenesis, salivary glands, TGFβ1 expression is responsible for disruption of one of the glandular branches in the oral cavity and has an important role in regulating the proliferation and differentiation of epithelial cells. This can affect the homeostatic process in the oral mucosa (Bernardi et al, 2018) This has been proven in studies using experimental animals suffering from diabetes mellitus. The results explained that in these animals, the production of TGFβ isoforms in the salivary glands was impaired (Lamers et al, 2007).…”

Section: Introductionmentioning

confidence: 98%

Saliva Tgfβ1 level in patients with type 2 diabetes mellitus and primary hypertension on dental caries

Masriadi¹,

Tasyah

Aldilawati

et al. 2022

ijhs

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The aim of this study is to analyze the relationship and differences in salivary Tgfβ1 levels in patients with type 2 diabetes mellitus (T2DM) and primary hypertension (PH) with dental caries patients. Salivary TGFβ1 levels of patients with T2DM & Caries, PH with dental caries were 577.85 pg/ml (0.042) and 386.3894 pg/ml (0.024). Then continued with testing the effect of TGFβ1 on T2DM and PH patients with dental caries, namely T2DM patients (p. 0.042) and PH patients (p. 0.024). This shows that there is a significant effect between salivary TGFβ1 levels of T2DM and PH patients on dental caries. Likewise, it was found that there was a significant difference between T2DM and PH in dental caries by looking at the average value of salivary TGFβ1 on PH was 386,3894pg/mL while salivary TGFβ1 on T2D was 577,8546pg/mL. It can also be seen from the standard deviation value of T2DM deviation is 173.04621, while HTP is 95.93092. There is associated and difference of Salivary TGFβ1 levels of patients with T2DM and PH at the age of 18-40 years with dental caries. The higher the salivary TGFβ1 level, the higher the risk of dental caries.

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“… [47] Systemic disorders such as diabetes, hypertension and cardiovascular diseases alter oral immune barriers. [48] , [49] , [50] Increased circulating inflammatory mediators and oxidative stress in these disorders may lead to increased susceptibility to cross-reactions with pathogenic organisms manifesting as oral lesions. [50] , [51] It takes centerstage in light of recent discovery of cross-immune reactivity between SARS-CoV-2 antibodies and cell junction proteins- occludin, zonulin, beta-catenin.…”

Section: Introduction/backgroundmentioning

confidence: 99%

Rise and exacerbation of oral lichen planus in the background of SARS-CoV-2 infection

et al. 2021

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Oral Lichen Planus (OLP) is a chronic inflammatory disorder whose exact etiology remains unknown. Inflammatory mediators, cytotoxic CD8+ T cells and mast cells have been hypothesized to mediate the pathogenesis of OLP. COVID-19 pandemic caused by SARS-CoV-2 is marked by cytokine storms in the affected patients. Altered T-cell responses marked by exhaustion of T-cell count with hyperaggressive remaining T-cells and presence of cross-reactive antibodies render infected humans as fertile grounds for development of multisystem disorders. In addition, Vitamin D deficiency in COVID-19 patients can further modify the T cell mediated immunity. Increased circulating cytokines and hyperactive CD8+ T cells can alter the oral immune barriers rendering them susceptible to oral disorders. Due to the widespread immune dysregulation, it is possible that patients of COVID-19 may develop OLP in the aftermath or during recovery. The paper explores the pathogenic mechanism behind development OLP as post-COVID condition on account of their target receptor, T-cell responses, cytokine profile, mucosal immune barriers and nutrition deficiency.

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Effects of Diabetes and Hypertension on Oral Mucosa and TGFβ1 Salivary Levels

Cited by 5 publications

References 28 publications

Analysis of Oral Chronic Kidney Disease with Hemodialysis Therapy in South Kalimantan - Indonesia

Analysis of Oral Chronic Kidney Disease with Hemodialysis Therapy in South Kalimantan - Indonesia

Saliva Tgfβ1 level in patients with type 2 diabetes mellitus and primary hypertension on dental caries

Rise and exacerbation of oral lichen planus in the background of SARS-CoV-2 infection

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