Diabetic Rats Present High Mean Platelet Count in the Presence of Oral Infections

Ferreira, Leonardo L. G.; Filho, João Eduardo Gomes; Sumida, Dóris Hissako; Bonfim, Suely Regina Mogami; Sivieri-Araújo, Gustavo; Guimarães, Gustav; Cintra, Luciano Tavares Ângelo

doi:10.1590/0103-6440201701386

Cited by 8 publications

(7 citation statements)

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“…These effects may be represented by an increase in triglyceride levels, 41 HbA1c serum levels, 28 proinflammatory cytokine IL-17 levels, 30 inflammatory cells in the blood, 29 and platelets. 42 In addition, the studies showed that the associations among AP, PD, and diabetes increased the weights of the brain, heart, and gonads and the total body weight of rats. 43 According to the authors, these results demonstrate that AP can affect the body system.…”

Section: Continuationmentioning

confidence: 99%

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

et al. 2018

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Endodontic medicine, which addresses the bidirectional relationship between endodontic infections and systemic diseases, has gained prominence in the field of endodontics. There is much evidence showing that while systemic disease may influence the pathogenesis of endodontic infection, endodontic infection can also cause systemic alterations. These alterations include more severe bone resorption and inflammation in the periapical area as well as enhanced systemic disease symptoms. Similarly, many reports have described the impact of systemic diseases on the tissue responses to dental materials. Conversely, the local use of dental materials may show systemic effects in the form of altered production of biomarkers. Thus, studies to better understand the mechanisms related to those connections are extremely important. In this context, the objective of this review was to analyze and discuss the current literature regarding the connections among these three factors-systemic diseases, endodontic infection, and endodontic dental materials-and determine how these connections may interfere in the systemic health status and the endodontic treatment outcomes, which are represented by periapical wound healing.

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Section: Continuationmentioning

confidence: 99%

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

et al. 2018

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“…Only four articles met the inclusion criteria: 2 studies in animals [38,39] and 2 studies in humans [40,41]. Finally, 21 article were included, 10 studies in animals [22][23][24][25][26][27][28][29]38,39], 10 studies in humans [30][31][32][33][34][35][36][37]40,41] and 1 systematic review [11] (Figure 1).…”

Section: Study Selectionmentioning

confidence: 99%

“…Levels of evidence in animals. Analysis of the levels of evidence in animal studies showed that nine studies had a B recommendation (90%), with a level of evidence of 3b [22,30], 7 studies had a B recommendation with a level of evidence 2b [24][25][26][27][28][29]31] and one study with grade of recommendation A and level of evidence 1b (10%) [23].…”

Section: Quality Assessmentmentioning

confidence: 99%

“…Of the animal studies, 100% were performed in mice, representing 595 mice, in five studies the n was greater than 80, representing 408 mice [24][25][26], [29,30]. In four studies, the n was greater than 40 with a total of 167 mice [22,27,28,31] and in a single trial the n was of 20 mice [23].…”

Section: Quality Assessmentmentioning

confidence: 99%

“…Both oral infections increased the total number of leukocytes, neutrophils, lymphocytes and glucose concentrations in mice with DM.Azuma et al, 2017[27] 2b/B ♀Winstar mice n = 40 (10 each group) Normoglycemic rats (N); Normoglycemic rats with apical periodontitis (N-AP); rats with experimental diabetes (ED), and rats with experimental diabetes and apical periodontitis (ED-AP) Nr AP did not impact the levels of IL-17 in hepatic and renal tissues, irrespective of the presence or absence of diabetes. There is an increase of IL-17 levels in the periapical region of diabetic rats without AP (ED) as compared to control rats (N), and an increase of IL-17 levels in AP rats with experimental diabetes (ED-AP) was observed as compared to the N-AP.Prieto et al, 2017[28] 2b/B ♀Winstar mice n = 40 (10 each group) G1:CG, G2: AP, G3: DM, G4: DM + AP YesMicroscopically in the groups with AP (AP and DM + AP), an increase in the intensity and extent of the inflammatory infiltrate was noted, periapical lesions in the diabetic rats were higher and more aggressive compared with that in normoglycemic rats, AP associated with diabetes reduced the serum levels of albumin and increased the endogenous antioxidant uric acid.Ferreira et al, 2017[29] 2b/B ♀Winstar mice n = 80 (10 each group) G1:CG, G2: AP, G3:PD, G4:AP + PD, G5:DM, G6: DM + AP, G7: DM + PD, G8:DM + AP + PDNrThe presence of oral infections increased blood glucose concentrations in diabetic rats. DM + PD and DM + AP + PD groups had higher mean values of platelet count with statistical difference compared to CG and AP groups.AP: apical periodontitis; CG: control group; DM: diabetes mellitus; DM2: diabetes mellitus type 2; M: meta-analysis; no-DM: no diabetes mellitus; HbA1c: glycated haemoglobin; n: sample; PD: periodontal disease; TG: treatment group; #: Diabetes mellitus was induced with Streptozotocin, apical periodontitis with oral exposition and periodontal disease by periodontal ligature.…”

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Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis

Pérez‐Losada

Estrugo‐Devesa

Castellanos-Cosano

et al. 2020

JCM

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Objective: Investigate if there is an association between apical periodontitis and diabetes mellitus. Material and methods: A bibliographic search was performed on Medline/PubMed, Scopus and Cochrane databases using the keywords apical periodontitis and diabetes mellitus. Published papers written in English and performed on animals or humans were included. Meta-analysis was performed using the OpenMeta (analyst) tool for the statistical analysis. The variables analyzed were the prevalence of Apical Periodontitis (AP) among teeth and patients with Diabetes Mellitus (DM). Results: Of the total studies found, only 21 met the inclusion criteria. Ten clinical studies on animals, ten studies on humans and a systematic review were included. Meta-analysis shows that the prevalence of teeth with apical periodontitis among patients with diabetes mellitus has an odds ratio of 1.166 corresponding to 507 teeth with AP + DM and 534 teeth with AP without DM. The prevalence of patients with AP and DM shows an odds ratio of 1.552 where 91 patients had AP + DM and 582 patients AP without DM. Conclusion: Scientific evidence suggests that there could be a common physiopathological factor between apical periodontitis and diabetes mellitus but more prospective studies are needed to investigate the association between these two diseases.

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Evolution of endodontic medicine: a critical narrative review of the interrelationship between endodontics and systemic pathological conditions

et al. 2021

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Endodontics has gained emphasis in the scientific community in recent years due to the increase in clinical and in animal models studies focused on endodontic medicine, which aims to evaluate the interrelationship between systemic and periapical tissues pathological conditions. These studies have shown that systemic changes can boost the pathogenesis of endodontic infection, favoring its development and progression. A contrary relationship is reported in numerous studies that affirm the potential of endodontic infection to trigger systemic damage and may lead to the worsening of pre-existing pathologies. Recently, the potential of filling materials to develop systemic changes such as neurological alterations had been evaluated, also showing that systemic diseases can negatively influence tissue responses to filling materials after endodontic treatment. Despite advances in endodontic medicine studies, there are still gaps in knowledge on the mechanisms of interactions between apical periodontitis (AP) and systemic diseases and much research to be done. In this sense, this critical narrative literature review aimed to show the evolution of studies in endodontic medicine to help the endodontist to know the role of systemic diseases in the pathogenesis of AP and the possible interference in the repair of periapical tissues after endodontic treatment, as well as to evidence the systemic complications that can be triggered or aggravated in the presence of endodontic infection.

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Diabetic Rats Present High Mean Platelet Count in the Presence of Oral Infections

Cited by 8 publications

References 22 publications

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis

Evolution of endodontic medicine: a critical narrative review of the interrelationship between endodontics and systemic pathological conditions

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