Frequency of Cancer in First-Degree Relatives of Patients with Cleft Lip and/or Palate in the Brazilian Population

Lima, Leonardo Santos; Silverio, Matheus de Oliveira; Swerts, Mário Sérgio Oliveira; Aquino, Sibele Nascimento de; Martelli, Daniella Reis Barbosa; Martelli‐Júnior, Hercílio

doi:10.1590/0103-6440201302191

Cited by 14 publications

(9 citation statements)

References 21 publications

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“…Two previous studies did not find association between oral cleft and cancer. However, Steinwachs et al 33 evaluated first and second-degree relatives, and Lima et al 37 evaluated only first-degree relatives. In our study, we could detect the association only in the third degree relatives.…”

Section: Discussionmentioning

confidence: 99%

DLX1 and MMP3 contribute to oral clefts with and without positive family history of cancer

Sabóia¹,

Reis²,

Martins³

et al. 2015

Archives of Oral Biology

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Section: Discussionmentioning

confidence: 99%

DLX1 and MMP3 contribute to oral clefts with and without positive family history of cancer

Sabóia¹,

Reis²,

Martins³

et al. 2015

Archives of Oral Biology

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“…Several studies from different countries (USA, Latvia, Denmark, and Brazil) have identified an association between cleft palate and cancer [90][91][92][93][94][95]. The first epidemiological studies addressed the presence of cancer in cleft lip/palate subjects and their families.…”

Section: Cleft Palate and Cancermentioning

confidence: 99%

8 Epidemiology of Cleft Lip and Palate

Losee¹,

Kirschner²

2016

Comprehensive Cleft Care, Volume 1

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Orofacial cleft (OFC) anomalies are amongst the most common congenital anomalies and the most common craniofacial anomalies. Despite their poorly characterized etiologies, cases of OFC are usually grouped by epidemiological studies as cleft lip, with or without cleft palate (CL/P), and cleft palate alone (CPO). Incidence of CL/P and CPO differs according to gender and ancestry and may vary widely across studies. Cases of OFC are characterized as either "syndromic" or "nonsyndromic," with further classification of nonsyndromic cases into isolated cases and cases that present with additional malformations. The genetic bases for many syndromic cases of OFC have been previously elucidated. Genetic associations have been described for nonsyndromic OFC as well. Importantly, etiology of OFC is known to involve interaction between genetic and environmental factors, including maternal nutrition and exposure to teratogenic agents. Furthermore, evidence points toward epigenetic as well as genetic factors influencing OFC etiology. Recent studies have begun to explore the association between CL/P and cancer. These studies report higher incidence of cancer among patients with CL/P and their family members as well as identification of common genetic markers mediating this increased risk, although much remains unknown about this link.

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“…The concept is that genes acting during the normal development may also have an important role in malignancies [6]. Over the past years, epidemiological studies have investigated the association of cancer with NSOC in different populations, including those from the United States, Southeast Asia, Denmark, Latvia, India, the Netherlands, Turkey, France, Poland, Pakistan, and Brazil [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26], and the results are controversial. Thus, the aim of this study was to determine the frequency of NSOC in families of patients with a diagnosis of ALL.…”

Section: Introductionmentioning

confidence: 99%

Nonsyndromic Oral Cleft in First-Degree Relatives of Patients with Acute Lymphoblastic Leukemia

et al. 2020

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Multiple studies have demonstrated an association between cancer and nonsyndromic oral clefts in different populations. In this study, we assessed the occurrence of nonsyndromic oral clefts in families of patients with acute lymphoblastic leukemia (ALL, n = 50) and controls (n = 125). The parents of the patients answered a questionnaire with basic demographic information and family history of nonsyndromic oral clefts in first-degree relatives. Statistical analysis was carried out using Fisher’s exact test. In the ALL group, 22 (44%) were male and 28 (56%) were female, and the average age was 13.2 ± 12.2 years. In the control group, 64 (51.2%) were male and 65 were female and the average age was 11.3 ± 10.3 years. Two out of 50 patients (4%) with acute lymphoblastic leukemia had a positive history of nonsyndromic oral clefts, whereas there were no reported occurrences of nonsyndromic oral clefts in the control group (OR: 12.94, 95% CI: 0.61–274.6, p = 0.08). Despite the limited population, the frequency of nonsyndromic oral clefts was increased in the first-degree relatives of patients with acute lymphoblastic leukemia. Studies with larger samples and molecular analyses are needed to better understand the possible etiological relationship between cancer and nonsyndromic oral clefts.

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Frequency of Cancer in First-Degree Relatives of Patients with Cleft Lip and/or Palate in the Brazilian Population

Cited by 14 publications

References 21 publications

DLX1 and MMP3 contribute to oral clefts with and without positive family history of cancer

DLX1 and MMP3 contribute to oral clefts with and without positive family history of cancer

8 Epidemiology of Cleft Lip and Palate

Nonsyndromic Oral Cleft in First-Degree Relatives of Patients with Acute Lymphoblastic Leukemia

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