Improvement in Oxidative Stress After Duodenojejunostomy in an Experimental Model of Type 2 Diabetes Mellitus

Wietzycoski, Cácio Ricardo; Marchesini, João Caetano; Al-Themyat, Sultan; Meyer, Fabiola Shons; Trindade, Manoel Roberto Maciel

doi:10.1590/0102-6720201600s10002

Cited by 7 publications

(5 citation statements)

References 25 publications

(32 reference statements)

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“…Our findings show that DJOS surgery reduces the deleterious impact of an HF/HF diet on OS but does not act efficiently under the condition of a change in dietary pattern. Other studies confirm the reduction in oxidative stress and a downregulation of antioxidant enzymes after duodenojejunostomy in the insulin resistance and diabetic animal models [ 14 ].…”

Section: Discussionmentioning

confidence: 66%

“…In relation to HF diet, Auberval et al proved the increase of tissue but not plasma oxidative stress among the studied animals [ 12 ] and Pinho et al revealed that HFD induces skeletal muscle OS in rats [ 13 ]. Similarly, bariatric surgery procedures have been linked to a reduction in oxidative stress in rats [ 14 ]. DJOS is a relatively new technique; thus, an animal model, for exploring the long-term physiological effects and pathophysiological outcomes of this procedure, is still needed [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Status in the Soleus Muscle of Sprague‐Dawley Rats in Relation to Duodenal‐Jejunal Omega Switch and Different Dietary Patterns

Skrzep-Poloczek

Stygar

Chełmecka

et al. 2018

Oxidative Medicine and Cellular Longevity

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Background Obesity and chronic ingestion of lipid-rich meals are related to an enhanced oxidative stress (OS). Aims To examine the influence of duodenal-jejunal omega switch surgery in combination with different diets on the antioxidative status in the soleus muscle of rats. Methods After 8 weeks on a high-fat diet (HF) or control diet (CD), rats underwent duodenal-jejunal omega switch (DJOS) or SHAM (control) surgery. After surgery, for the next 8 weeks, half of DJOS/SHAM animals were kept on the same diet as before, and half had a changed diet. The total superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and glutathione reductase (GR) activity as well as malondialdehyde (MDA) concentration were measured in the soleus of rats. Results CAT and GPx activity were significantly lower after DJOS surgery versus SHAM, regardless of the type of diet. The activity of CAT, SOD, GR, CuZnSOD, and GPx was altered in the CD/HF or HF/CD groups. After DJOS, the lowest muscle concentration of MDA was observed in the CD/CD group and the highest in CD/HF. Conclusions DJOS surgery significantly decreases the antioxidative system in soleus muscles of rats. CD/HF and HF/CD dietary patterns lead to an increase in antioxidative activity, while remaining on unchanged diet (CD or HF) is associated with a reduced oxidative stress.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Antioxidant Status in the Soleus Muscle of Sprague‐Dawley Rats in Relation to Duodenal‐Jejunal Omega Switch and Different Dietary Patterns

Skrzep-Poloczek

Stygar

Chełmecka

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Diabetes is associated with increased oxidative stress [ 21 , 22 ]. SOD [ 23 , 24 ], AST [ 25 , 26 ], ALT [ 27 , 28 ], and GSH are associated with oxidative stress [ 29 – 34 ].…”

Section: Methodsmentioning

confidence: 99%

Actinidia chinensis Planch. Improves the Indices of Antioxidant and Anti‐Inflammation Status of Type 2 Diabetes Mellitus by Activating Keap1 and Nrf2 via the Upregulation of MicroRNA‐424

Sun

et al. 2017

Oxidative Medicine and Cellular Longevity

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The fruit juice of Actinidia chinensis Planch. has antioxidant and anti-inflammation properties on patients with type 2 diabetes mellitus (T2DM), but the molecular mechanism was unclear. The patients took the juice and the serum level of antioxidant miR-424, Kelch-like ECH-associated protein 1 (Keap1), erythroid-derived 2-like 2 (Nrf2), and biochemical indices were measured. The juice increased the levels of serum microRNA-424, Keap1, and Nrf2 and reduced the levels of interleukin-1 (IL-1) beta and IL-6 in T2DM patients. The levels of SOD and GSH were higher while the levels of ALT and AST were lower in the patients consuming the juice when compared to the patients without taking the juice. The Spearman rank correlation analysis showed that the serum levels of miR-424 were positively related to Keap1 and Nrf2 levels while Keap1 and Nrf2 levels were positively related to the levels of SOD and GSH and negatively related to IL-1 beta and IL-6. Thus, FJACP improves the indices of antioxidant and anti-inflammation status by activating Keap1 and Nrf2 via the upregulation of miR-424 in the patients with T2DM. This trial is registered with ChiCTR-ONC-17011087 on 04/07/2017.

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“…In the placental uterus process, it is assumed that oxidative stress is a causal factor in chronic complications and can be measured based on the level of thiobarbituric acid reactive substances (TBARS) and catalase activity 10 .…”

Section: ■ Introductionmentioning

confidence: 99%

Oxidative stress effects in the uterus, placenta and fetus of pregnant rats submitted to acute and chronic stress

Silveira

Aydos²,

Ramalho³

et al. 2018

Acta Cir. Bras.

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To evaluate the effects of oxidative stress in pregnant rats submitted to acute and chronic stress, relating to alterations in the uterus, placenta and fetus. Methods: Twenty-four female Wistar albino (Rattus norvegicus), were divided into four groups, for induction of oxidative stress the animals were submitted to cold and physical immobilization. Plasma fasting glucose and MDA were determined in all groups and the fetuses and placentas were measured. Results: There were no statistical differences in the levels of malonic dialdehyde (MDA), however the averages of chronic stress group were higher compared to control groups, which could explain the observed adverse effects; there was no correlation between puppies' size, the weight of the placenta and MDA values. Conclusions: Chronic stress causes adverse effects, when compared to control groups; chronic stress group had fetuses, placentas and number of puppies, significantly lower compared to other groups. The rats exposed to chronic stress, also presented a higher frequency of fetal resorption.

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Improvement in Oxidative Stress After Duodenojejunostomy in an Experimental Model of Type 2 Diabetes Mellitus

Cited by 7 publications

References 25 publications

Antioxidant Status in the Soleus Muscle of Sprague‐Dawley Rats in Relation to Duodenal‐Jejunal Omega Switch and Different Dietary Patterns

Antioxidant Status in the Soleus Muscle of Sprague‐Dawley Rats in Relation to Duodenal‐Jejunal Omega Switch and Different Dietary Patterns

Actinidia chinensis Planch. Improves the Indices of Antioxidant and Anti‐Inflammation Status of Type 2 Diabetes Mellitus by Activating Keap1 and Nrf2 via the Upregulation of MicroRNA‐424

Oxidative stress effects in the uterus, placenta and fetus of pregnant rats submitted to acute and chronic stress

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