Pediatric Liver Transplantation With Ex-Situ Liver Transection and the Application of the Human Fibrinogen and Thrombin Sponge in the Wound Area

Vicentine, Fernando Pompeu Piza; Gonzalez, Adriano Miziara; Azevedo, Ramiro Anthero de; Benini, B.B.; Linhares, Marcelo Moura; Filho, Gaspar de Jesus Lopes; Martins, José Luiz; Netto, Alcides Augusto Salzedas

doi:10.1590/0102-6720201600040006

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…These devices are the main goals of surgeons in trials to improve results. To obtain effective hemostasis from traumatic or surgical lesions of parenchymal viscera, especially the liver, has always been a challenge 11 , 12 , 15 . The possibility of use of different substances leaded to the production of collagen and lower inflammatory reaction, when compared with conventional sutures 2 , 4 , 5 , 10 …”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Surgical Hemostatic Sponges in Liver Injury: Study in Rats

Fontes

Mardegam

Prado-Filho

et al. 2018

ABCD, arq. bras. cir. dig.

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BackgroundObtaining effective hemostasis either in the traumatic or surgical lesions of parenchymal viscera, especially the liver, has always been a challenge. Aim: Comparative study between the use of different hemostatic sponges in hepatic wound and their capacity of integration to cells in a short period. Methods: Fifteen Wistar rats were divided into three groups. Through laparotomy a standardized wound in hepatic right lobe was made. The animals were treated with three sponges, being gelatin in group I, equine collagen in group II, and oxidized cellulose in group III. The hemostatic capacity was analysed. On the 7º day after surgery samples for histology analysis (H&E and picrosirius) were collected for inﬂammatory evaluation and collagen quantification (types I and III) with polarized microscopy. Results: All materials used had similar haemostatic effects, with no significant difference in hemostasis time. In the assessment of tissue repair and adhesions provoked, as well as analysis of the inflammatory process, the gelatin sponge presented greater inflammation and adhesions to the contiguous structures to the procedure in relation to the other groups. Conclusion: Animals which had their wounds treated with collagen and regenerated cellulose sponges presented better results in relationship to the ones treated with gelatin sponge.

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Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Surgical Hemostatic Sponges in Liver Injury: Study in Rats

Fontes

Mardegam

Prado-Filho

et al. 2018

ABCD, arq. bras. cir. dig.

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“…The first liver transplantation in humans was done in the 60s by Thomas Starzl. Since that time to the current days several landmarks have been conquered improving surgical technique, ameliorating grafts preservation during transportation, controlling cellular rejection, and preventing infections on post-transplantation period 19 , 20 , 22 .…”

Section: Introductionmentioning

confidence: 99%

Effects of Cold Ischemia Time on Hepatic Allograft Function

Freitas

Matos

Milsted

et al. 2017

ABCD, arq. bras. cir. dig.

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-Background:Cold ischemia time is related to success of liver transplantation. Aim: To compare the impact of cold ischemia time on allografts locally collected to those collected distantly. Methods: Were evaluated 83 transplantations. The patients were divided in two groups: those who received liver grafts collected from cities out of Curitiba (n=42) and locally (n=41). From the donors were compared: cause of death, days at ICU, cardiac arrest, vasoactive drugs, lab exams, gender, age, and BMI. Were compared the subsequent information of receptors: cold ischemia time, warm ischemia time, length of surgery, lab exams, etiology of cirrhosis, MELD score, age, gender, histology of graft, use of vasoactive drugs, and blood components transfusion. Were evaluated the correlation between cold ischemia time and lab results. Results: The liver grafts collected from other cities were submitted to a longer cold ischemia time (500±145 min) compared to those locally collected (317,85±105 min). Donors from other cities showed a higher serum sodium level at donation (154±16 mEq/dl) compared to those from Curitiba (144±10 mEq/dl). The length of cold ischemia time was related to serum levels of ALT and total bilirubin. Conclusion: Liver grafts distantly collected underwent longer cold ischemia times, although it caused neither histologic injuries nor higher transfusion demands. There is a correlation between cold ischemia time and hepatic injury, translated by elevation of serum ALT and total bilirubin levels. RESUMO -Racional:O tempo de isquemia fria está relacionado ao sucesso do transplante hepático. Objetivo: Comparar o impacto do tempo dela sobre enxertos captados localmente com os distantes. Métodos: Avaliaram-se 83 transplantes. Os pacientes foram divididos em dois grupos: enxertos captados fora de Curitiba (n=42) e captados localmente (n=41). Dos doadores compararam-se causa do óbito, dias de UTI, parada cardíaca, drogas vasoativas, exames laboratoriais, gênero, idade e IMC. Dos receptores seguintes dados: tempos de isquemia fria e morna, tempo operatório, exames laboratoriais, causa da cirrose, MELD, idade na operação, gênero, biópsia do enxerto, uso de drogas vasoativas e necessidade de transfusões. Foi realizada avaliação de correlação entre o tempo de isquemia fria e os exames laboratoriais. Resultados: Os enxertos captados à distância foram submetidos a maior tempo de isquemia fria (500,3±145 min) quando comparados aos captados localmente (317,85±105 min). Os doadores de fora apresentaram níveis mais elevados de sódio no momento da doação (154±16 mEq/dl) comparados aos doadores de Curitiba (144±10 mEq/dl). Houve correlação entre o tempo de isquemia fria e os níveis de ALT e de bilirrubina total. Não houve diferenças ao comparar-se os demais dados. Conclusão: Enxertos captados à distância sofreram maior tempo de isquemia fria. Isso não refletiu nos prejuízos histológicos nem na demanda transfusional durante o pós-operatório. Houve correlação entre o tempo de isquemia fria e o grau de lesão hepática avaliada p...

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Direct Cloning, Expression and Purification of Human Activated Thrombin in Prokaryotic System and CD Analysis Report of Produced Thrombin: Molecular Characterization of Recombinant Thrombin

Barkhordari

Behzad-Behbahani

Jajarmi

et al. 2020

Int J Pept Res Ther

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Pediatric Liver Transplantation With Ex-Situ Liver Transection and the Application of the Human Fibrinogen and Thrombin Sponge in the Wound Area

Cited by 5 publications

References 33 publications

Comparative Analysis of Surgical Hemostatic Sponges in Liver Injury: Study in Rats

Comparative Analysis of Surgical Hemostatic Sponges in Liver Injury: Study in Rats

Effects of Cold Ischemia Time on Hepatic Allograft Function

Direct Cloning, Expression and Purification of Human Activated Thrombin in Prokaryotic System and CD Analysis Report of Produced Thrombin: Molecular Characterization of Recombinant Thrombin

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