Prevalência de anticorpos contra SARS-CoV-2 em Mato Grosso, Brasil: pesquisa de base populacional

Abstract

Dados de soroprevalência oferecem informações relevantes relacionadas ao desenvolvimento e progressão de pandemia da COVID-19. Estimar a prevalência de anticorpos anti-SARS-CoV-2 em Mato Grosso, Brasil e sua distribuição segundo características sociodemográficas e econômicas. Inquérito soroepidemiológico de base populacional conduzido entre setembro e outubro de 2020, com indivíduos de 18 anos ou mais de idade, em dez municípios do Estado de Mato Grosso. As entrevistas e coleta de material biológico foram realizadas em domicílio, e a determinação de anticorpos IgG contra o SARS-CoV-2 foi feita por meio da quimioluminescência. Foram 4.306 indivíduos avaliados, e a prevalência de COVID-19 foi estimada em 12,5% (IC95%: 10,5; 14,7), variando de 7,4% a 24,3% entre os municípios. Não foram verificadas diferenças na prevalência da infecção segundo raça/cor da pele, escolaridade ou renda familiar, entretanto verificou-se menor prevalência entre indivíduos que residiam com algum morador que recebia aposentadoria, que não receberam auxílio financeiro emergencial e que a renda familiar não diminuiu após as medidas de distanciamento social para enfrentamento da epidemia. A prevalência de anticorpos contra SARS-CoV-2 estimada nesta pesquisa de base populacional é essencial para conhecer a magnitude da doença no estado e subsidiará ações de combate e controle da pandemia.

Self-reported symptoms and seroprevalence against SARS-CoV-2 in the population of Mato Grosso: a household-based survey in 2020

“…Furthermore, less than half of those who reported symptoms compatible with COVID-19 sought health services. These results show the importance of asymptomatic carriers in the transmission of COVID-19, as pointed out above, [17][18][19][20] also highlighting the critical proportion of people who did not perform diagnosis and isolation measures to prevent transmission between their contacts even with symptoms similar to the disease.…”

“…Table 2. Proportion of symptoms and prevalence ratio (PR), according to the presence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Mato Grosso, 2020 Undocumented infected cases are estimated as primary source for the geographic spread of COVID 17,22 and the proportion of asymptomatic is considerable, reaching rates ranging from 9.2-69%. However, the range of symptoms produced by COVID-19 is knowingly broad, varying by clinical form of the disease, and may manifest in different systems, with a predominance in the respiratory, neurological, and gastrointestinal systems 2,5,11 .…”

“…The sample was estimated as 4,530 individuals, proportionally distributed by population size of the municipalities (25,000-65,000 inhabitants; 65,000-150,000 inhabitants; 150,000-300,000 inhabitants; >300,000 inhabitants; >300,000 inhabitants). Further details about the sampling design and the draw of households are available in the study by Oliveira et al 17 .…”

Prevalence of Ivermectin use to prevent COVID-19 during the pandemic in Mato Grosso: cross-sectional home-based study

“…This is a home-based survey carried out between September and October 2020 in ten hub municipalities in the socioeconomic regions of the state, the main cities being: Cuiabá, Várzea Grande, Cáceres, Rondonópolis, Barra do Garças, Tangará da Serra, Alta Floresta, Água Boa, Juína, and Sinop. A cross-sectional design was adopted, with cluster sampling in three stages: census sector (selected with probability proportional to the number of permanent households, according to data from the 2010 census); households (selected based on systematic sampling); residents over 18 years old (one randomly selected resident) 10 .…”

“…The percentage of 13% recomposition was added to the sample size, considering anticipated losses from refusals and closed households during visits. More details about the study design can be seen in Oliviera et al 10 .…”