Interações medicamentosas potenciais entre idosos em uso dos anti-hipertensivos da Relação Nacional de Medicamentos Essenciais do Ministério da Saúde do Brasil

Mibielli, Pablo; Rozenfeld, Suely; Matos, Guacira Corrêa de; Acúrcio, Francisco de Assis

doi:10.1590/0102-311x00126213

Cited by 27 publications

(39 citation statements)

References 15 publications

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“…The association between polypharmacy and the occurrence of DI corroborates other Brazilian studies 11,33 . Thus, as DI is a constant risk, especially among elderly people who use polypharmacy, knowledge about the subject is vital in order to avoid greater risks to the health of these individuals 11 .…”

Section: Discussionsupporting

confidence: 90%

“…The association between the presence of possible DI and age found in the present study diverged from an investigation of elderly persons living in the community in the city of Rio de Janeiro 11 . The relationship between increasing age and the occurrence of DI deserves further investigation 10,11 , as the aging process may contribute to the increase in the prevalence of chronic diseases, which causes the elderly to use more drugs 7 , resulting in a greater possibility of DI 10,27 .…”

Section: Discussionmentioning

confidence: 99%

“…7 . DI is the pharmacological or clinical response that arises from the interference of the action of a particular drug, food or any chemical on the effect of another drug, administered prior or concomitantly to the first medication 11 . It can be classified according to severity, such as: severe when potentially resulting in life-threatening and/or irreversible damage, requiring urgent medical intervention to minimize adverse effects; moderate when they can cause a worsening of the patient's clinical condition and/or may require additional treatment, hospitalization, or if the patient is already hospitalized, lead to longer hospitalization; and minor when the clinical effects are mild and the consequences may result in discomfort for the individual but do not require major changes in therapy 12 .…”

Section: Introductionmentioning

confidence: 99%

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Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

Tavares

Gomes

Rodriguês

et al. 2018

Rev. bras. geriatr. gerontol.

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Objectives: To describe the sociodemographic, clinical and pharmacotherapy characteristics of elderly persons with metabolic syndrome and to identify factors associated with drug interactions among these individuals. Method: A quantitative, analytical and transversal study was carried out among 263 elderly people with metabolic syndrome in the urban area of Uberaba, Minas Gerais, Brazil. Possible drug interactions were identified and classified according to the Micromedex® DrugReax System. The chi-squared test and the multiple logistic regression model were used for analysis ( p<0.05). Results: The majority of the individuals were female (70.7%); aged 60 to 74 years (72.3%); lived with a spouse/ partner (63.9%); had some schooling (74.1%); an individual monthly income of ≤ one minimum wage (77.1%); lived with others (88.2%); had five or more morbidities (89.7%) and exhibited polypharmacy (73.0%); used potentially inappropriate medications (54.4%) and had possible drug interactions (75.3%). Associated with the possible presence of drug interactions were: age range ( p=0.005), polypharmacy ( p<0.001) and use of potentially inappropriate medications ( p=0.006). Conclusion: Possible drug interactions were associated with increased age, polypharmacy and the use of potentially inappropriate medications. This study contributes to knowledge of these possible interactions among elderly people with metabolic syndrome, and as such can be considered an important tool for planning actions to ensure the safety of these individuals who, due to the complexity of their treatment, use multiple medications.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

Tavares

Gomes

Rodriguês

et al. 2018

Rev. bras. geriatr. gerontol.

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“…The explanatory variables with a p ≤ .25 calculated using univariate analyses were included in the logistic regression model along with clinically relevant variables (age, sex, diagnosis and the number of drugs) because they are the most frequently mentioned in the literature as potential variables associated with DDIs. All variables that presented p ≤ .25 in the unadjusted model were included in the adjusted models (Lao et al, 2013;Lea et al, 2013;Mibielli et al, 2014;Oesterhus et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Potential drug–drug interactions and polypharmacy in institutionalized elderly patients in a public hospital in Brazil

Castilho

Reis

Borges

et al. 2017

Psychiatric Ment Health Nurs

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Introduction Despite the impact on patient safety and the fact that prevalence is higher in older patients, previous research did not analyse drug-drug interactions (DDIs) in view of nursing care of elderly psychiatric patients. Aim To identify potential drug-drug interactions and polypharmacy in prescriptions of aged inpatients with psychiatric disorders and analyse associated factors. Methods In this retrospective cross-sectional study, we analysed the medical records of institutionalized patients diagnosed with psychiatric disorders (n = 94), aged >60 years, and prescribed multiple medications. Drug prescriptions were checked at admission, midway through and the last prescription. Factors associated with DDI occurrence were assessed using multivariable logistic regression analysis. Results A DDI prevalence potential of 67.0%, 74.5% and 80.8% occurred in patients at admission, midway through hospitalization and the last prescription, respectively. Most of the prescribed drugs were nervous system agents. A high percentage of serious and contraindicated potential DDIs occurred. Age between 60 and 69 years, use of cardiovascular and respiratory system drugs, and the number of medications contributed significantly to DDI. Implications for mental health nursing Knowledge on the factors associated with DDIs in patients with mental disorders can contribute to the improvement of effectiveness and safety of nursing care.

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“…A number of other studies have also identified an increase number of medications a predictor of DDI in the elderly [6, 9, 15, 30, 34–41]. A study from Brazil reported that the potential drug interaction risk when patients are taking 2–3, 4–5 and 6–7 medications was 39, 88.8 and 100 %, respectively [36].…”

Section: Discussionmentioning

confidence: 99%

Potential drug–drug interactions among elderly patients admitted to medical ward of Ayder Referral Hospital, Northern Ethiopia: a cross sectional study

et al. 2016

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BackgroundThe elderly are considered as special population, as they differ from younger adults in terms of comorbidity, polypharmacy, pharmacokinetics, vulnerability to drug–drug interactions and adverse drug reactions. Despite the fact that the elderly patients are at high risk of having drug interaction and potential adverse outcomes, studies in this regard are scarce in resource limited settings like Ethiopia. The aim of this study was to assess the prevalence and determinants of potential drug–drug interaction in elderly patients admitted to medical ward of Ayder Referral Hospital in Northern Ethiopia.MethodsA cross sectional study was conducted among elderly inpatients aged 60 years and above. The study was conducted from February to May 2014. Prescribed drugs being taken concurrently for at least 24 h were included and checked for drug–drug interaction using Micromedex® 2.0 online drug reference. Data were analyzed using statistical software, statistical package for social sciences for windows version 20. Logistic regression model was used to analyze factors associated with occurrence of drug interaction. P value of <0.05 was considered statistically significant.ResultsA total of 140 patients were participated in the study. The mean age (±standard deviation) of participants was 68 (±7) years. Majority (61.4 %) of patients were diagnosed with cardiovascular and/or renal diseases. A total of 814 drugs were prescribed with a mean of 6 (±4) medications per patient during a 13 (±9) days of hospital stay. About two-third (62.2 %) of the respondents were exposed to at least one potential drug–drug interaction. Among these 3.6, 32.9 and 25.7 % of patients had taken contraindicated drug combination, at least one major and at least one moderate drug–drug interaction, respectively. Patients with five or more prescribed medications were four times at risk of having drug–drug interaction (P = 0.00; adjusted odds ratio 4.047; 95 % confidence interval 1.867–8.775).ConclusionDrug–drug interaction in elderly patients was common in this resource limited set-up. Awareness creation and clinical pharmacist involvement in minimizing the risk associated with potentially harmful drug combinations are needed.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-016-2238-5) contains supplementary material, which is available to authorized users.

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Interações medicamentosas potenciais entre idosos em uso dos anti-hipertensivos da Relação Nacional de Medicamentos Essenciais do Ministério da Saúde do Brasil

Abstract: Abstract

Cited by 27 publications

References 15 publications

Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

Profile of elderly persons with metabolic syndrome and factors associated with possible drug interactions

Potential drug–drug interactions and polypharmacy in institutionalized elderly patients in a public hospital in Brazil

Potential drug–drug interactions among elderly patients admitted to medical ward of Ayder Referral Hospital, Northern Ethiopia: a cross sectional study

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