Síndrome da infecção congênita pelo vírus Zika

Eickmann, Sophie Helena; Carvalho, Maria Durce Costa Gomes; Ramos, Regina Coeli Ferreira; Rocha, Maria Ângela Wanderley; Linden, Vanessa van der; Silva, Paula Fabiana Sobral da

doi:10.1590/0102-311x00047716

Cited by 70 publications

(80 citation statements)

References 11 publications

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“…The congenital Zika syndrome is a set of signs and symptoms present since birth and goes beyond microcephaly, with variable sequelae of severity, since ZIKV leads to congenital infection through vertical transmission and damages the developing brain, interfering in the multiplication and migration of CNS cells, causing the acceleration of apoptosis, altering the central nerve characteristics of myelin formation of the CNS, and disorganizing the synapses between neurons (Eikmann et al, ; Melo et al, ).…”

Section: Introductionmentioning

confidence: 99%

Dental changes in children with congenital Zika syndrome

et al. 2019

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Objective To describe oral alterations in children with congenital Zika syndrome (CZS). Methods This was a case series, whose research instrument was a structured questionnaire, associated with the use of medical record data and extra and intraoral clinical examination. Results Thirty‐two children were evaluated, the majority male (18/32%–56.3%), mean age 22 months (SD = 2.71). It was also observed that the majority of the patients (19/32%–59.4%) presented a low family income. All the children had a mean head circumference of 29.43 cm (SD = 1.42). Regarding the alterations, an ogival‐shaped palate was observed in 14 children (43.7%), and delayed chronology of eruption was observed in 15 children (46.9%), of whom 7 children (21.9%) did not present eruption of the upper left lateral incisor (p = .0002) and upper right lateral incisor (p = .002) until the moment of analysis. Additionally, 03 children with yellowish dental pigmentation were identified in erupted teeth after the onset of phenobarbital use. Enamel hypoplasia was identified in 9 children (28.1%) and only one child with ankyloglossia. Conclusion CZS may present delayed chronology of eruption, ankyloglossia, ogival‐shaped palate, and enamel hypoplasia, requiring dental follow‐up aimed at prevention, promotion, and rehabilitation of the health of these children.

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Section: Introductionmentioning

confidence: 99%

Dental changes in children with congenital Zika syndrome

et al. 2019

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“…CZS is characterized by microcephaly and cerebral malformations. This disease is also associated with other signs and symptoms, such as visual and auditory alterations and symptoms that are uncommon in congenital infections, such as arthrogryposis (Chimelli et al, ; Eickmann et al, ). With regard to neuroimaging, cortical/subcortical calcifications, cortical malformations, ventriculomegaly and cerebral hypoplasia have been reported (Aragão et al, ; Del Carpio‐Orantes, Rosas‐Lozano, & García‐Méndez, ; Eickmann et al, ; Leal, Muniz, Caldas Neto, Van der Linden, & Ramos, ).…”

Section: Discussionmentioning

confidence: 99%

Orthopedic findings in arthrogryposis and congenital Zika syndrome: A case series

Serpa¹,

Melo

Lins³

et al. 2019

Birth Defects Research

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Background Congenital arthrogryposis (CA) consists of congenital joint contractures that affect at least two joints in different parts of the body. Approximately, 80% of CA cases are neurogenic, with changes to the formation, structure or functioning of the central and/or peripheral nervous systems. Most abnormalities are triggered either by motoneurons decreased activation in the corticospinal tract or by direct motoneurons injury. There had been few reports in the literature correlating congenital infection in humans with arthrogryposis until 2015. CA has recently been described associated with congenital Zika syndrome (CZS). Methods The objective of this study was to investigate and describe accurately the arthrogrypotic alterations in infants diagnosed with CZS and thus, suggest a possible pattern of orthopedic impairment. A total of 198 medical records of infants with CZS were evaluated. According to inclusion and exclusion criteria, 17 infants were included in the present study. Arthrogrypotic joints were orthopedically evaluated in four segments: right, left, upper, and lower limbs. All the four segments were assessed independently. Results Flexed wrists were the most frequently observed manifestation, associated with ulnar deviation (35.29%). Deformities were also commonly found in the third and fourth fingers (64.70%). Hip dislocation was found in 58.82% of the patients and talipes equinovarus and equinovalgus ankles were found in 29.41 and 23.52%. Conclusion There was a particular pattern of joint impairment related to CZS and arthogrypotic alterations of infants evaluated in this study.

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“…O estado de Pernambuco despontou no cenário epidemiológico nacional com a ocorrência de epidemia de infecção pelo vírus zika e aumento do número de casos de SZC num curto período de tempo (EICKMANN ET AL., 2016;PERNAMBUCO, 2016).…”

Section: Considerações Finaisunclassified

“…Em outubro de 2015, além dos casos confirmados de infecção pelo vírus zika, outro evento foi registrado no Estado: profissionais de dois hospitais da capital Recife notificaram à Secretaria de Saúde aumento no número de recém-nascidos com microcefalia para 26 casos (EICKMANN ET AL., 2016;PERNAMBUCO, 2016). A partir dessa comunicação, o Centro de Informações Estratégicas em Vigilância em Saúde de Pernambuco (Cievs-PE) comprovou alteração no padrão de ocorrência dessa anomalia congênita, uma vez que, entre os anos de 2005 e 2014, sua mediana era de nove registros por ano.…”

Section: Introductionunclassified

“…Nesses casos, constataram--se características distintas das observadas em recém-nascidos com microcefalia provocada por outras infecções congênitas, mostrando marcantes calcificações difusas, puntiformes, predominantes na junção córtico-subcortical. Chama à atenção, ainda, a microcefalia, geralmente grave, e outras dismorfias como acentuada protuberân-cia óssea occipital, fontanelas fechadas ao nascer, excesso de pele ou dobras de pele no escalpo, além de hérnia umbilical (EICKMANN ET AL., 2016). Esses achados fizeram com que, em menos de dois meses, fossem publicados dois protocolos clínicos epidemiológicos estaduais, de modo a estabelecer parâmetros mais específicos para notificação (PERNAMBUCO, 2016).…”

Section: Introductionunclassified

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Painel estadual de monitoramento da infecção pelo vírus zika e suas complicações: caracterização e uso pela Vigilância em Saúde

et al. 2017

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RESUMOAs epidemias causadas por arboviroses, especialmente pelo vírus zika e suas complicações, destacaram-se como importantes problemas de saúde pública no âmbito global. O estado de Pernambuco despontou tanto nas ações de vigilância e atenção à saúde integradas dessas doenças, como no seu monitoramento. Esse é essencial no aprimoramento da gestão em situações de emergência em saúde pública. Objetiva-se aqui relatar o desenvolvimento de painel estadual de monitoramento focado nessas doenças. Espera-se contribuir para o aperfeiçoamento de intervenções que objetivem alcançar resultados semelhantes, uma vez que o monitoramento de casos, considerados inéditos, favorece ao aprendizado institucional.

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Síndrome da infecção congênita pelo vírus Zika

Cited by 70 publications

References 11 publications

Dental changes in children with congenital Zika syndrome

Dental changes in children with congenital Zika syndrome

Orthopedic findings in arthrogryposis and congenital Zika syndrome: A case series

Painel estadual de monitoramento da infecção pelo vírus zika e suas complicações: caracterização e uso pela Vigilância em Saúde

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