Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment

Abstract

Objective: Not only white blood cells but also platelets are being considered in inflammatory reactions from now on. Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) have been shown to change in inflammatory diseases like myocardial infarction, stroke and implicated in psychiatric disorders nowadays. Our first aim is to investigate the relation of MPV and NLR with depression and secondly to assess if they change with the treatment of depression. Methods: Forty-nine patients diagnosed with major depressive disorder (MDD) and hospitalized in a university hospital psychiatry inpatient unit retrospectively included in the study. Control group consisted of 48 hospital workers with no known disease. Complete blood count, Hamilton Depression Rating Scale (HAM-D) and Clinical Global Impression-Severity Scale (CGI-S) scores at admission and at discharge were noted and compared for the patient group. Discussion: MPV of depressed patients was higher than controls. When we look at admission and discharge scores of clinical scales, decrement is statistically significant for both HAM-D and CGI-S. There was decline both in MPV and NLR which were both statistically significant. Conclusion: Decreasing MPV and NLR values with the treatment of depression confirm the involvement of inflammatory processes in the pathophysiology of depression.Öztürk A et al. / Arch Clin Psychiatry. 2019;46(1):9-13

Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Monocyte-to-Lymphocyte Ratio in Depression: An Updated Systematic Review and Meta-Analysis

“…The eighteen studies ( 17 , 35 , 37 , 38 , 41 , 42 , 46 – 49 , 52 – 56 , 102 ) selected in this meta-analysis were published between 2015 and 2021, and consisted of 2,264 depression cases and 2,415 controls. As displayed in Table 1 , we summarized the main characteristics of these studies.…”

Clinical and Biological Factors Are Associated with Treatment-Resistant Depression

“…Similarly, other studies reported higher NLR in suicide attempters than individuals without suicidal behaviour [ 63 , 66 ]. Conversely, there is evidence that antidepressants treatment might influence inflammatory processes by affecting proliferation of lymphocyte, hence decreasing NRL [ 67 , 68 ]. In addition, the finding of a lower NLR in TRD versus non-TRD patients is consistent with data reported by our group on a different sample showing that lower NLR levels are associated with violent suicide attempts [ 13 ].…”

Neutrophil/Lymphocyte ratio in patients with major depression and the impact of electroconvulsive therapy

“…These results support the presence of a subclinical inflammation dependent on the severity of major depression. Studies examining inflammation in the pathophysiology of major depression suggest that antidepressants tend to reduce inflammation [9,10]. What role does ECT play in inflammation, used in particular in the treatment of resistant and severe depression?…”

“…Hamilton Depression Rating Scale: The Hamilton depression rating scale is used to measure the severity of depression. The score ranges of the scale (0-7) represent no depression; (8)(9)(10)(11)(12)(13)(14)(15)(16) mild depression; (17-23) moderate depression; (≥24) and severe depression [13]. A 50% decrease in the HamD scale equates to response to [14] treatment.…”

“…It has been reported that the P/L ratio increases in psychotic and severe major depression [8]. The number of studies on the anti-inflammatory effects of antidepressants prescribed for major depression has been increasing recently, and it is thought that even anti-inflammatory agents can serve as clinically relevant antidepressants [9,10]. Electroconvulsive therapy is another important treatment option for major depression.…”