Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

Yıldız, Mesut; Celikel, Feryal Cam; Ateş, Ömer; Taycan, Serap Erdoğan; Benli, İsmail; Demir, Osman

doi:10.1590/0101-60830000000123

Cited by 6 publications

(2 citation statements)

References 26 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The human paraoxonase 1 enzyme (PON1) is linked with the high-density lipoprotein (HDL) that has broad substrate specificity. PON1 is an antiinflammatory and antioxidant enzyme serving as a paraoxonase and arylesterase (Yildiz et al, 2017). The single nucleotide polymorphisms (SNPs) in the coding regions (192Q/R and 55LM) of the PON1 gene have been found.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

ASSOCIATION OF GSTM1 AND PARAOXINASE-1 (L55M & Q192R) POLYMORPHISMS WITH CHRONIC ORGANOPHOSPHORUS INTOXICATION IN EGYPTIAN PESTICIDE APPLICATORS.

Elhalafawy

Gadalla²,

elseidy³

2023

The Egyptian Journal of Forensic Sciences and Applied Toxicolog

View full text Add to dashboard Cite

Background: At work, farmers are more likely to come into contact with pesticides and other agricultural contaminants. The permanent inhibition of acetylcholinesterase (AChE) at nerve synapses is thought to be a systemic impact of organophosphates (OPs). However, several investigations have shown that AChE inhibition alone does not account for all toxicological effects associated with longterm OP exposure. Although oxidative stress and epigenetic modifications are two of the most recently hypothesized mechanisms, the existence of genetic variations appears to have the greatest influence on biological outcomes. Objectives: The purpose of this study is to investigate the polymorphisms in genes that code for OPs metabolizing enzymes. Because the glutathione-S-transferase (GSTM1) and paraoxonase (PON1) genes encode enzymes that breakdown pesticides with carcinogenic potential, we're particularly interested in them. Methodology: From June to December 2018, a cross-sectional study was done on 24 pesticide applicators and 25 corresponding controls. Serum AChE activities were determined using the EQM Test-Mate kit. Using polymerase chain reaction-restriction fragment length polymorphism, the influence of genetic polymorphism in GSTM1 and PON1 on OPs exposure was examined. Results: Compared to the control group, chronically exposed patients had significantly lower serum AChE enzyme activity (<0.001). In terms of the GSTM1 polymorphism and the R allele of the PON1 (Q192R) polymorphism, there was a significant difference between chronic OP exposed cases and controls. The PON1 (LM) polymorphism was found to be of little consequence. Conclusion: Finally, the GSTM1 and R allele of PON1(LM) polymorphisms may be a risk factor for chronic organophosphates intoxication in Egyptian pesticide applicators.

show abstract

Section: Introductionmentioning

confidence: 99%

“…PON1 activity and levels are influenced by the L55M (Ceja-Gálvez et al, 2020). The Q192R polymorphism influences the enzyme's hydrolytic activity (Yildiz et al, 2017). Due to genetic variation in GSTs, the GSTM1 gene has polymorphism, and its null genotype may impact reducing enzyme activity.…”

Section: Introductionmentioning

confidence: 99%

ASSOCIATION OF GSTM1 AND PARAOXINASE-1 (L55M & Q192R) POLYMORPHISMS WITH CHRONIC ORGANOPHOSPHORUS INTOXICATION IN EGYPTIAN PESTICIDE APPLICATORS.

Elhalafawy

Gadalla²,

elseidy³

2023

The Egyptian Journal of Forensic Sciences and Applied Toxicolog

View full text Add to dashboard Cite

show abstract

The Incidence of the XRCC1 rs25487 and PON1 rs662 Polymorphisms in a Population from Central Brazil: Patterns in an Area with a High Level of Agricultural Activity

et al. 2023

View full text Add to dashboard Cite

In Brazil, high levels of agricultural activity are re ected in the consumption of enormous amounts of pesticide. The production of grain in Brazil has been estimated to reach 289.8 million tons in the 2022 harvest, an increase of 14.7% in comparison with 2021, with an even greater increase being predicted for Goiás, one of the country's principal grain producing states. These advances are likely associated with a progressive increase in the occupational exposure of rural workers to pesticides. The PON1 gene activates the enzymes involved in phase I of liver detoxi cation. The rs662 variant of this gene is known to modify the activity of the PON1 enzyme, which can increase the susceptibility of an individual to pesticides, leading to more severe symptoms or the development of diseases. The present study describes the frequencies of the rs25487 (of the XRCC gene) and rs662 variants and their haplotypes in a sample population from Goiás, Brazil, and compares the frequencies with other populations from around the world to verify the variation in the distribution of these Single Nucleotide Polymorphisms (SNPs). The study analyzed samples taken from 494 unrelated individuals resident in the state of Goiás. The A allele of the rs25487 variant had a frequency of 26% in the Goiás study population, and the modi ed rs662 G allele had a frequency of 42.8%. Four haplotypes were recorded for the rs25487 (G > A) and rs662 (A > G) markers, with a frequency of 11.9% being recorded for the A/G haplotype (both modi ed alleles), 30.8% for the G/G haplotype, 14.3% for the A/A haplotype, and 42.8% for the G/A haplotype (both wild-type alleles). In conclusion, we demonstrated the distribution of important SNPs associated with pesticide exposure in an area that presents a high level of agricultural activity.

show abstract

Paraoxonase 1 status is a major Janus-faced component of mild and moderate acute ischemic stroke and consequent disabilities

et al. 2023

View full text Add to dashboard Cite

Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

Cited by 6 publications

References 26 publications

ASSOCIATION OF GSTM1 AND PARAOXINASE-1 (L55M & Q192R) POLYMORPHISMS WITH CHRONIC ORGANOPHOSPHORUS INTOXICATION IN EGYPTIAN PESTICIDE APPLICATORS.

ASSOCIATION OF GSTM1 AND PARAOXINASE-1 (L55M & Q192R) POLYMORPHISMS WITH CHRONIC ORGANOPHOSPHORUS INTOXICATION IN EGYPTIAN PESTICIDE APPLICATORS.

The Incidence of the XRCC1 rs25487 and PON1 rs662 Polymorphisms in a Population from Central Brazil: Patterns in an Area with a High Level of Agricultural Activity

Paraoxonase 1 status is a major Janus-faced component of mild and moderate acute ischemic stroke and consequent disabilities

Contact Info

Product

Resources

About