“…Traditionally, depression in patients with ALS has been measured using instruments that were not specific to the disease ( 19 ) and included other variables related to motor abilities, which hamper accurate diagnosis ( 16 ). These instruments include the Hospital Anxiety and Depression Scale (HADS) ( 20 ), and the Neuropsychiatric Inventory (NPI) ( 21 ), which measure delusions, hallucinations, dysphoria, anxiety, agitation/aggression, euphoria, disinhibi-tion, irritability/lability, apathy, aberrant motor activity in patients with dementia, the Beck Depression Inventory (BDI) ( 22 ); the Hamilton Depression Rating Scale (HDRS) ( 23 ), and the Patient Health Questionnaire (PHQ-9) ( 24 ).…”