Behavioral manifestations in a Brazilian non-demented C9orf72-negative ALS population

Branco, Lucas M. T.; Zanão, Tamires; Rezende, Tiago Marques de; Paraguay, Isabela B. B.; Leoni, Tauana Bernardes; Balthazar, Márcio Luiz Figueredo; França, Marcondes C.

doi:10.1080/21678421.2019.1704014

Cited by 3 publications

(2 citation statements)

References 47 publications

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“…There is a relative lack of large studies describing the overlap between the two conditions in Latin America, which might be related to the scarcity of adequate cognitive screening methods suitable for Spanish- and Portuguese-speaking populations with low education. To the best of our knowledge, there are only two cohorts studies exploring cognitive and behavioral presentations overlapping with MND/ALS ( 130 , 131 ).…”

Section: Resultsmentioning

confidence: 99%

Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research

et al. 2021

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Introduction: The historical development, frequency, and impact of frontotemporal dementia (FTD) are less clear in Latin America than in high-income countries. Although there is a growing number of dementia studies in Latin America, little is known collectively about FTD prevalence studies by country, clinical heterogeneity, risk factors, and genetics in Latin American countries.Methods: A systematic review was completed, aimed at identifying the frequency, clinical heterogeneity, and genetics studies of FTD in Latin American populations. The search strategies used a combination of standardized terms for FTD and related disorders. In addition, at least one author per Latin American country summarized the available literature. Collaborative or regional studies were reviewed during consensus meetings.Results: The first FTD reports published in Latin America were mostly case reports. The last two decades marked a substantial increase in the number of FTD research in Latin American countries. Brazil (165), Argentina (84), Colombia (26), and Chile (23) are the countries with the larger numbers of FTD published studies. Most of the research has focused on clinical and neuropsychological features (n = 247), including the local adaptation of neuropsychological and behavioral assessment batteries. However, there are little to no large studies on prevalence (n = 4), biomarkers (n = 9), or neuropathology (n = 3) of FTD.Conclusions: Future FTD studies will be required in Latin America, albeit with a greater emphasis on clinical diagnosis, genetics, biomarkers, and neuropathological studies. Regional and country-level efforts should seek better estimations of the prevalence, incidence, and economic impact of FTD syndromes.

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Section: Resultsmentioning

confidence: 99%

Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research

et al. 2021

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“… 57 In a recent Brazilian study with 70 C9orf72 negative patients, and including 7 patients with VAPB variants, 23% of the patients were diagnosed with ALSbi and apathy followed by dysphoria and anxiety were the most prevalent findings in the ALSbi subgroup. 58 Chiò and colleagues evaluated 2839 ALS patients in Italy and disclosed important associations between ALS phenotype versus age, sex and genetics. 59 C9orf72 expansions correlated with bulbar phenotype and were less frequent in pure upper motor neuron forms.…”

Section: Resultsmentioning

confidence: 99%

Definitions, phenomenology, diagnosis, and management of the disorders of laughter and crying in amyotrophic lateral sclerosis (ALS): Consensus from ALS and Motor Neuron Disease Scientific Department of the Brazilian Academy of Neurology

Gondim,

Pinto,

Chieia

et al. 2023

Arq Neuropsiquiatr

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The spectrum of neuropsychiatric phenomena observed in amyotrophic lateral sclerosis (ALS) is wide and not fully understood. Disorders of laughter and crying stand among the most common manifestations. The aim of this study is to report the results of an educational consensus organized by the Brazilian Academy of Neurology to evaluate the definitions, phenomenology, diagnosis, and management of the disorders of laughter and crying in ALS patients. Twelve members of the Brazilian Academy of Neurology - considered to be experts in the field - were recruited to answer 12 questions about the subject. After exchanging revisions, a first draft was prepared. A face-to-face meeting was held in Fortaleza, Brazil on 9.23.22 to discuss it. The revised version was subsequently emailed to all members of the ALS Scientific Department from the Brazilian Academy of Neurology and the final revised version submitted for publication. The prevalence of pseudobulbar affect/pathological laughter and crying (PBA/PLC) in ALS patients from 15 combined studies and 3906 patients was 27.4% (N = 1070), ranging from 11.4% to 71%. Bulbar onset is a risk factor but there are limited studies evaluating the differences in prevalence among the different motor neuron diseases subtypes, including patients with and without frontotemporal dementia. Antidepressants and a combination of dextromethorphan and quinidine (not available in Brazil) are possible therapeutic options. This group of panelists acknowledge the multiple gaps in the current literature and reinforces the need for further studies.

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Apathy in amyotrophic lateral sclerosis: systematic review and meta-analysis of frequency, correlates, and outcomes

Кутлубаев

Caga

et al. 2022

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

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Behavioral manifestations in a Brazilian non-demented C9orf72-negative ALS population

Cited by 3 publications

References 47 publications

Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research

Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research

Definitions, phenomenology, diagnosis, and management of the disorders of laughter and crying in amyotrophic lateral sclerosis (ALS): Consensus from ALS and Motor Neuron Disease Scientific Department of the Brazilian Academy of Neurology

Apathy in amyotrophic lateral sclerosis: systematic review and meta-analysis of frequency, correlates, and outcomes

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