Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival

Gomes, Rodrigo Vieira; Rodrigues, Michele Ângela; Rodrigues, João Bernardo Sancio Rocha; Vidigal, P.T.; Damasceno, Karine Araújo; Lima, Henrique A.; Gomes, Dawidson Assis; Machado, Carla Jorge; Resende, Vívian

doi:10.1590/0100-6991e-20181826

Cited by 8 publications

(1 citation statement)

References 26 publications

(25 reference statements)

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“…This review included 15 different studies which report Epidermal Growth Factor Receptor (EGFR) presence in CCA [ 50 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ]. Ten out of fifteen studies investigating EGFR involve Eastern tissue specimens from Japan, China, Korea, and Thailand with 5/15 originating from USA, Brazil, Italy, and Germany.…”

Section: Resultsmentioning

confidence: 99%

Translating Biomarkers of Cholangiocarcinoma for Theranosis: A Systematic Review

Wijetunga

McVeigh

Charalambous

et al. 2020

Cancers

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Cholangiocarcinoma (CCA) is a rare disease with poor outcomes and limited research efforts into novel treatment options. A systematic review of CCA biomarkers was undertaken to identify promising biomarkers that may be used for theranosis (therapy and diagnosis). MEDLINE/EMBASE databases (1996–2019) were systematically searched using two strategies to identify biomarker studies of CCA. The PANTHER Go-Slim classification system and STRING network version 11.0 were used to interrogate the identified biomarkers. The TArget Selection Criteria for Theranosis (TASC-T) score was used to rank identified proteins as potential targetable biomarkers for theranosis. The following proteins scored the highest, CA9, CLDN18, TNC, MMP9, and EGFR, and they were evaluated in detail. None of these biomarkers had high sensitivity or specificity for CCA but have potential for theranosis. This review is unique in that it describes the process of selecting suitable markers for theranosis, which is also applicable to other diseases. This has highlighted existing validated markers of CCA that can be used for active tumor targeting for the future development of targeted theranostic delivery systems. It also emphasizes the relevance of bioinformatics in aiding the search for validated biomarkers that could be repurposed for theranosis.

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Section: Resultsmentioning

confidence: 99%

Translating Biomarkers of Cholangiocarcinoma for Theranosis: A Systematic Review

Wijetunga

McVeigh

Charalambous

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) is overexpressed in cholangiocarcinoma and its expression correlates with S100 calcium-binding protein A4 (S100A4)

Rodrigues

Gomes

Cosme

et al. 2022

Biomedicine & Pharmacotherapy

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A novel synthetic acanthoic acid analogues and their cytotoxic activity in cholangiocarcinoma cells

Kasemsuk

Saehlim

Arsakhant

et al. 2021

Bioorganic & Medicinal Chemistry

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Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival

Abstract: EGFR expression occurred in 28.6% of the cases studied and was associated with lower survival.

Cited by 8 publications

References 26 publications

Translating Biomarkers of Cholangiocarcinoma for Theranosis: A Systematic Review

Translating Biomarkers of Cholangiocarcinoma for Theranosis: A Systematic Review

Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) is overexpressed in cholangiocarcinoma and its expression correlates with S100 calcium-binding protein A4 (S100A4)

A novel synthetic acanthoic acid analogues and their cytotoxic activity in cholangiocarcinoma cells

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